{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:14:59Z","timestamp":1790021699840,"version":"4.0.1"},"reference-count":41,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:sec id=\"ab-ooi230004-4\"><jats:title>Importance<\/jats:title><jats:p>Although sentinel lymph node biopsy (SLNB) is a vital staging tool, its application in head and neck melanoma (HNM) is complicated by a higher false-negative rate (FNR) compared with other regions. This may be due to the complex lymphatic drainage in the head and neck.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230004-5\"><jats:title>Objective<\/jats:title><jats:p>To compare the accuracy, prognostic value, and long-term outcomes of SLNB in HNM with melanoma from the trunk and limb, focusing on the lymphatic drainage pattern.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230004-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This cohort observational study at a single UK University cancer center included all patients with primary cutaneous melanoma undergoing SLNB between 2010 to 2020. Data analysis was conducted during December 2022.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230004-7\"><jats:title>Exposures<\/jats:title><jats:p>Primary cutaneous melanoma undergoing SLNB between 2010 to 2020.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230004-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>This cohort study compared the FNR (defined as the ratio between false-negative results and the sum of false-negative and true-positive results) and false omission rate (defined as the ratio between false-negative results and the sum of false-negative and true-negative results) for SLNB stratified by 3 body regions (HNM, limb, and trunk). Kaplan-Meier survival analysis was used to compare recurrence-free survival (RFS) and melanoma-specific survival (MSS). Comparative analysis of detected lymph nodes on lymphoscintigraphy (LSG) and SLNB was performed by quantifying lymphatic drainage patterns by number of nodes and lymph node basins. Multivariable Cox proportional hazards regression identified independent risk factors.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230004-9\"><jats:title>Results<\/jats:title><jats:p>Overall, 1080 patients were included (552 [51.1%] men, 528 [48.9%] women; median age at diagnosis 59.8 years), with a median (IQR) follow-up 4.8 (IQR, 2.7-7.2) years. Head and neck melanoma had a higher median age at diagnosis (66.2 years) and higher Breslow thickness (2.2 mm). The FNR was highest in HNM (34.5% vs 14.8% trunk or 10.4% limb, respectively). Similarly, the false omission rate was 7.8% in HNM compared with 5.7% trunk or 3.0% limbs. The MSS was no different (HR, 0.81; 95% CI, 0.43-1.53), but RFS was lower in HNM (HR, 0.55; 95% CI, 0.36-0.85). On LSG, patients with HNM had the highest proportion of multiple hotspots (28.6% with \u22653 hotspots vs 23.2% trunk and 7.2% limbs). The RFS was lower for patients with HNM with 3 or more affected lymph nodes found on LSG than those with fewer than 3 affected lymph nodes (HR, 0.37; 95% CI, 0.18-0.77). Cox regression analysis showed head and neck location to be an independent risk factor for RFS (HR, 1.60; 95% CI, 1.01-2.50), but not for MSS (HR, 0.80; 95% CI, 0.35-1.71).<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230004-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>This cohort study found higher rates of complex lymphatic drainage, FNR, and regional recurrence in HNM compared with other body sites on long-term follow-up. We advocate considering surveillance imaging for HNM for high-risk melanomas irrespective of sentinel lymph node status.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamaoto.2023.0076","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T16:01:13Z","timestamp":1678377673000},"page":"416","source":"Crossref","is-referenced-by-count":25,"title":["Association of Complex Lymphatic Drainage in Head and Neck Cutaneous Melanoma With Sentinel Lymph Node Biopsy Outcomes"],"prefix":"10.1001","volume":"149","author":[{"given":"Terouz","family":"Pasha","sequence":"first","affiliation":[{"name":"Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohaib","family":"Arain","sequence":"additional","affiliation":[{"name":"Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United 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