{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:17:43Z","timestamp":1787325463016,"version":"build-2736575974"},"reference-count":39,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec id=\"ab-ooi230048-4\"><jats:title>Importance<\/jats:title><jats:p>Human papillomavirus (HPV) vaccination rates remain significantly below rates for other common childhood vaccines, which has implications for future rates of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC).<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230048-5\"><jats:title>Objective<\/jats:title><jats:p>To assess whether individuals who were aware of the association between HPV and OPSCC would be more likely to have been previously vaccinated.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230048-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This survey study included patients aged 18 to 45 years who sought routine outpatient care at the otolaryngology clinic at Boston Medical Center from September 1, 2020, to May 19, 2021. A survey (HPV-Associated Head and Neck Cancer Epidemiology, Awareness and Demographics) [HEAD]) composed of validated questions to assess patient knowledge of HPV and HPV vaccination and barriers to vaccination was delivered to participants. The survey was paired with a novel point-of-care vaccination program housed within an otolaryngology department.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230048-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The main outcome was prevalence of knowledge of the relationship between HPV infection and OPSCC based on survey responses. The association of knowledge of HPV-associated OPSCC with likelihood of having been vaccinated was assessed in the overall cohort and by demographic characteristics using multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230048-8\"><jats:title>Results<\/jats:title><jats:p>Of 405 patients given the survey, 288 (71.1%) responded. Of these patients, 271 (94.1%) had surveys included; 158 (58.3%) were female, and median age was 29 years (IQR, 24-35 years). The baseline vaccination rate in the surveyed population was low (26.6%; n\u2009=\u200972) overall (10.6% among men [12 of 113]; 37.9% among women [60 of 158]). Few participants understood the relationship between HPV infection and OPSCC (63 of 271 [23.3%]) or that HPV-associated OPSCC is the most common HPV-associated cancer type (9 of 121 [7.4%]). Compared with men, women were more likely to have been previously vaccinated (odds ratio [OR], 6.5; 95% CI, 3.0-13.9), more aware that HPV causes cancer (OR, 3.7; 95% CI, 1.9-7.1), and more likely to have heard about HPV and HPV vaccination from their health care practitioner (OR, 2.6; 95% CI, 1.2-5.7). Knowledge of the relationship between HPV infection and cancer and between HPV and OPSCC was associated with increased likelihood of having been vaccinated (HPV and cancer: OR, 4.1 [95% CI, 1.8-9.5]; HPV and OPSCC: OR, 3.7 [95% CI, 1.8-7.6]). Among 156 unvaccinated participants, 12 of 98 men (12.2%) and 7 of 131 women (5.3%) received point-of-care vaccination.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230048-9\"><jats:title>Conclusions<\/jats:title><jats:p>Most participants in this survey study were unaware that HPV causes OPSCC. Understanding that HPV causes OPSCC was associated with increased likelihood of having been vaccinated. However, most patients surveyed were not informed of this relationship by their health care practitioners. Targeted education aimed at unvaccinated adults establishing the relationship between HPV infection and OPSCC, paired with point-of-care vaccination, may be an innovative strategy for increasing HPV vaccination rates in adults.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamaoto.2023.2073","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T15:55:59Z","timestamp":1693497359000},"page":"870","source":"Crossref","is-referenced-by-count":13,"title":["Deciphering Knowledge and Opinions of Human Papillomavirus and Human Papillomavirus Vaccination for Facilitation of Point-of-Care Vaccination in Adults"],"prefix":"10.1001","volume":"149","author":[{"given":"Jacob C.","family":"Bloom","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Boston Medical Center, Boston, 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