{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:23:10Z","timestamp":1791285790241,"version":"4.1.0"},"reference-count":55,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec id=\"ab-ooi230100-4\"><jats:title>Importance<\/jats:title><jats:p>There is limited literature on the exact causes and ways of death in patients with head and neck cancer. To provide optimal care, especially in the palliative phase, more information on this is needed.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230100-5\"><jats:title>Objective<\/jats:title><jats:p>To provide insights into the causes and ways of death among patients with head and neck cancer.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230100-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This retrospective cohort study included a consecutive population of patients who received a diagnosis of primary squamous cell carcinoma of the head and neck between January 2006 and December 2013 who were treated in the Erasmus MC. Patient data were merged with nonpublic microdata from Statistics Netherlands. Follow-up time was specified as the date of diagnosis until death or December 3, 2019, whichever came first. The data were checked and reanalyzed in November 2023.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230100-7\"><jats:title>Main outcomes and Measures<\/jats:title><jats:p>Causes (eg, head and neck cancer, other cancer) and ways (eg, natural death, suicide) of death.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230100-8\"><jats:title>Results<\/jats:title><jats:p>A total of 1291 patients (59.2%; 342 women [26.5%]) died during follow-up (median [IQR] follow-up, 2.7 [1.2-5.6] years). The main cause of death was head and neck cancer (557 [43.1%]), followed by the competing cause of other cancers (344 [26.6%]). In total, 240 patients (18.6%) received palliative sedation and 70 patients (5.4%) euthanasia. Compared with patients with head and neck cancer as the underlying cause of death, lower odds ratios (ORs) were observed for receiving palliative sedation (OR, 0.32 vs 0.07; 95% CI, 0.22-0.46 vs 0.03-0.12) and euthanasia (OR, 0.22 vs 0.01; 95% CI, 0.11-0.41 vs 0-0.107) in patients with other causes of death. Patients with a middle and high income had higher ORs for receiving palliative sedation (OR, 1.46 vs 1.86; 95% CI, 1.05-2.04 vs 1.22-2.85) or euthanasia (OR, 2.25 vs 3.37; 95% CI, 1.18-4.3, 1.6-7.12) compared with low-income patients. Retired patients had lower ORs for receiving palliative sedation or euthanasia compared with employed patients (OR, 0.56 vs 0.44; 95% CI, 0.39-0.8 vs 0.24-0.82).<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi230100-9\"><jats:title>Conclusion and Relevance<\/jats:title><jats:p>The results of this cohort study suggest that more than half of the patients died of competing causes and palliative sedation and euthanasia were more common in patients with head and neck cancer as the underlying cause of death. Patients with a higher socioeconomic status had higher odds of receiving palliative sedation and euthanasia. These insights may support health care professionals in providing patient-centered care, especially for patients in the palliative phase.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamaoto.2023.4694","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T16:01:36Z","timestamp":1708012896000},"page":"303","source":"Crossref","is-referenced-by-count":16,"title":["Causes and Ways of Death in Patients With Head and Neck Cancer"],"prefix":"10.1001","volume":"150","author":[{"given":"Boyd N.","family":"van den Besselaar","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniel","family":"Sewnaik","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arta","family":"Hoesseini","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten C.","family":"Dorr","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert. 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