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These cannabinoid substances have various systemic effects, and it is critical for otolaryngologists to recognize how cannabis use may contribute to a patient\u2019s care.<\/jats:p><\/jats:sec><jats:sec id=\"ab-orv240003-2\"><jats:title>Observations<\/jats:title><jats:p>Cannabis use has effects that contribute to every phase of a surgeon\u2019s care. Preoperative counseling for tapering use may prevent increased rates of adverse effects. Care with anesthesia must be observed due to increased rates of myocardial ischemia, higher tolerance to standard doses, and prolonged sedation. Although results of studies are mixed, there may be an association with cannabis use and postoperative pain, nausea, and vomiting. Postoperative wound healing may be improved through the use of topical cannabinoids. Significant drug-drug interactions exist with cannabis, most notably with several common anticoagulant medications. Care should be exercised when managing medications for people who use cannabis. While many people who use cannabis consume it infrequently, a substantial population has developed cannabis use disorder, which is associated with increased morbidity and mortality postoperatively. Screening for cannabis use disorder is important and can be done through short screening tools.<\/jats:p><\/jats:sec><jats:sec id=\"ab-orv240003-3\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Patients who use cannabis may require special attention regarding preoperative counseling and workup, intraoperative anesthesia, postoperative pain management, nausea, wound healing, and drug-drug interactions. As patient use continues to increase, otolaryngologists will find an increasing need to remain up to date on how cannabis use contributes to patient care.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamaoto.2024.2545","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T17:36:08Z","timestamp":1724348168000},"page":"918","source":"Crossref","is-referenced-by-count":15,"title":["Surgery-Related Considerations in Treating People Who Use Cannabis"],"prefix":"10.1001","volume":"150","author":[{"given":"Mark M.","family":"Mims","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Oklahoma Health Sciences Center, Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniruddha C.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Oklahoma Health Sciences Center, Oklahoma 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