{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:35:58Z","timestamp":1791974158909,"version":"4.4.0"},"reference-count":28,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"\n Importance<\/jats:title>\n There is a lack of high level of evidence studies comparing the effect of different treatment options for single-sided deafness (SSD).<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine the effect of a cochlear implant (CI), bone conduction device (BCD), contralateral routing of signals hearing aid (CROS), and no treatment on speech perception in noise outcomes in patients with SSD.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n In this single-center randomized clinical trial, adult patients with SSD were randomized into 3 groups: CI; a trial period with first a BCD on a headband and then a CROS; or a trial period with first a CROS and then a BCD on a headband. After the trial periods, patients opted for a BCD, CROS, or no treatment. Measurements were completed at baseline and at 3, 6, 12, and 24 months of follow-up. Data were collected from July 2014 to October 2021, and data were analyzed from December 2022 to May 2023.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n CI, BCD then CROS, or CROS then BCD.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome was the speech reception threshold in noise (SRTn), measured with speech and noise from the front (S0N0), speech directed to the poor ear and noise to the better ear (SpeNbe), and vice versa (SbeNpe). The secondary outcome was disease-specific quality of life (QOL).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 120 included patients, 60 (50.0%) were female, and the mean (SD) age at inclusion was 53.0 (12.1) years. At the start of follow-up, 28 patients received a CI, 25 a BCD, 34 a CROS, and 26 chose no treatment. At 24 months, the CI group had significantly better speech perception in noise scores than the BCD group (difference in SRTn: SbeNpe, \u22124.7 dB; 95% confidence interval, \u22126.6 to \u22123.0; SpeNbe, \u22122.2 dB; 95% confidence interval, \u22124.6 to \u22121.1), the CROS group (difference in SRTn: S0N0, \u22121.3 dB; 95% confidence interval, \u22121.7 to \u22120.2; SbeNpe, \u22125.3 dB; 95% confidence interval, \u22126.0 to \u22123.1), and the no treatment group (difference in SRTn: SpeNbe, \u22126.3 dB; 95% confidence interval, \u22127.5 to \u22124.9). Compared with the no treatment group, the BCD and CROS groups showed significantly better (difference in SRTn for SpeNbe, \u22124.1 dB [95% confidence interval, \u22125.2 to \u22121.5] and \u22124.1 dB [95% confidence interval, \u22126.1 to \u22123.3], respectively) or worse (difference for SbeNpe, 4.0 dB [95% confidence interval, 2.6 to 6.2] and 4.6 dB [95% confidence interval, 2.8 to 5.7], respectively) speech perception in noise. Self-reported speech perception abilities were significantly better for the CI group compared with the BCD, CROS, and no treatment groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this randomized clinical trial, the CI group outperformed the BCD, CROS, and no treatment groups in terms of speech perception in noise and disease-specific QOL in patients with SSD after 24 months of follow-up. These results indicate that patients with SSD can partially regain the advantages of binaural hearing after treatment.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n trialregister.nl Identifier:\n NL4457<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamaoto.2024.4760","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T11:00:38Z","timestamp":1737025238000},"page":"211","source":"Crossref","is-referenced-by-count":10,"title":["Speech Perception in Noise After Cochlear Implantation for Single-Sided Deafness"],"prefix":"10.1001","volume":"151","author":[{"given":"Jan A. A.","family":"van Heteren","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"},{"name":"UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne W.","family":"Wendrich","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"},{"name":"UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen P. M.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"},{"name":"UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilko","family":"Grolman","sequence":"additional","affiliation":[{"name":"Causse Ear Clinic, Colombiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Stokroos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"},{"name":"UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana L.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands"},{"name":"UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"6","key":"ooi240096r1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1159\/000455058","article-title":"Towards a unified testing framework for single-sided deafness studies: a consensus paper.","volume":"21","author":"Van de Heyning","year":"2016","journal-title":"Audiol Neurootol"},{"issue":"2","key":"ooi240096r2","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1055\/s-0038-1677482","article-title":"Cochlear implantation for single-sided deafness: a new treatment paradigm.","volume":"80","author":"Zeitler","year":"2019","journal-title":"J Neurol Surg B Skull Base"},{"issue":"4","key":"ooi240096r3","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1097\/MAO.0b013e31828779f0","article-title":"Tinnitus in a single-sided deaf ear reduces speech reception in the nontinnitus ear.","volume":"34","author":"Mertens","year":"2013","journal-title":"Otol Neurotol"},{"issue":"9","key":"ooi240096r4","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1177\/000348940811700903","article-title":"Incapacitating unilateral tinnitus in single-sided deafness treated by cochlear implantation.","volume":"117","author":"Van de Heyning","year":"2008","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"9","key":"ooi240096r5","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/S1474-4422(13)70160-1","article-title":"Tinnitus: causes and clinical management.","volume":"12","author":"Langguth","year":"2013","journal-title":"Lancet Neurol"},{"issue":"11","key":"ooi240096r6","first-page":"772","article-title":"Unilateral deafness in adults: effects on communication and social interaction.","volume":"119","author":"Wie","year":"2010","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"1","key":"ooi240096r7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1080\/14992027.2017.1398420","article-title":"The psychological and social consequences of single-sided deafness in adulthood.","volume":"57","author":"Lucas","year":"2018","journal-title":"Int J Audiol"},{"issue":"5","key":"ooi240096r8","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1097\/AUD.0000000000000313","article-title":"Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults: a systematic review and meta-analysis.","volume":"37","author":"Kitterick","year":"2016","journal-title":"Ear Hear"},{"issue":"1","key":"ooi240096r9","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/lary.24865","article-title":"Review: bone conduction devices and contralateral routing of sound systems in single-sided deafness.","volume":"125","author":"Peters","year":"2015","journal-title":"Laryngoscope"},{"issue":"10","key":"ooi240096r10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257447","article-title":"Short-term outcomes of cochlear implantation for single-sided deafness compared to bone conduction devices and contralateral routing of sound hearing aids\u2014results of a randomised controlled trial (CINGLE-trial).","volume":"16","author":"Peters","year":"2021","journal-title":"PLoS One"},{"issue":"2","key":"ooi240096r11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1177\/01945998221083283","article-title":"Cochlear implantation in adults with single-sided deafness: a systematic review and meta-analysis.","volume":"168","author":"Oh","year":"2023","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"ooi240096r12","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1055\/s-0035-1559586","article-title":"Cochlear implantation and single-sided deafness: a systematic review of the literature.","volume":"20","author":"Cabral Junior","year":"2016","journal-title":"Int Arch Otorhinolaryngol"},{"issue":"2","key":"ooi240096r13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1097\/MAO.0000000000000681","article-title":"Cochlear implantation for patients with single-sided deafness or asymmetrical hearing loss: a systematic review of the evidence.","volume":"36","author":"van Zon","year":"2015","journal-title":"Otol Neurotol"},{"key":"ooi240096r14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12901-015-0016-y","article-title":"CINGLE-trial: cochlear implantation for siNGLE-sided deafness, a randomised controlled trial and economic evaluation.","volume":"15","author":"Peters","year":"2015","journal-title":"BMC Ear Nose Throat Disord"},{"key":"ooi240096r15","doi-asserted-by":"publisher","first-page":"c332","DOI":"10.1136\/bmj.c332","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials.","volume":"340","author":"Schulz","year":"2010","journal-title":"BMJ"},{"issue":"3","key":"ooi240096r16","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1179\/146701011X13049348987832","article-title":"The AB-York crescent of sound: an apparatus for assessing spatial-listening skills in children and adults.","volume":"12","author":"Kitterick","year":"2011","journal-title":"Cochlear Implants Int"},{"key":"ooi240096r17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000370300","article-title":"Validation of the U-STARR with the AB-York crescent of sound, a new instrument to evaluate speech intelligibility in noise and spatial hearing skills.","volume":"5","author":"Smulders","year":"2015","journal-title":"Audiol Neurotol Extra"},{"issue":"2","key":"ooi240096r18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1080\/14992020400050014","article-title":"The Speech, Spatial and Qualities of Hearing Scale (SSQ).","volume":"43","author":"Gatehouse","year":"2004","journal-title":"Int J Audiol"},{"issue":"2","key":"ooi240096r19","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/14992027.2021.2020914","article-title":"Translation and validation of the Speech, Spatial, and Qualities of Hearing Scale (SSQ) and the Hearing Environments and Reflection on Quality of Life (HEAR-QL) questionnaire for children and adolescents in Dutch.","volume":"62","author":"Batthyany","year":"2023","journal-title":"Int J Audiol"},{"issue":"2","key":"ooi240096r20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3109\/1651386X.2012.673755","article-title":"Self-reported hearing performance among subjects with unilateral sensorineural hearing loss.","volume":"10","author":"Olsen","year":"2012","journal-title":"Audiol Med"},{"key":"ooi240096r21","doi-asserted-by":"publisher","DOI":"10.1177\/23312165241287092","article-title":"Sound localization in single-sided deafness; outcomes of a randomized controlled trial on the comparison between cochlear implantation, bone conduction devices, and contralateral routing of signals hearing aids.","volume":"28","author":"van Heteren","year":"2024","journal-title":"Trends Hear"},{"key":"ooi240096r22","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1428106","article-title":"Tinnitus reduction in patients with single-sided deafness: the effect of cochlear implantation, bone conduction devices, and contralateral routing of sound hearing aids investigated in a randomized controlled trial.","volume":"15","author":"Wendrich","year":"2024","journal-title":"Front Neurol"},{"issue":"5","key":"ooi240096r23","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/opo.12131","article-title":"When to use the Bonferroni correction.","volume":"34","author":"Armstrong","year":"2014","journal-title":"Ophthalmic Physiol Opt"},{"issue":"1","key":"ooi240096r24","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1002\/lio2.1002","article-title":"Choice of treatment evaluated after trial periods with bone conduction devices and contralateral routing of sound systems in patients with single-sided deafness.","volume":"8","author":"Wendrich","year":"2022","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"4","key":"ooi240096r25","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/MAO.0000000000003833","article-title":"Cochlear implantation outcomes in adults with single-sided deafness: a systematic review and meta-analysis.","volume":"44","author":"Daher","year":"2023","journal-title":"Otol Neurotol"},{"key":"ooi240096r26","first-page":"23","article-title":"The just-meaningful difference in speech-to-noise ratio.","volume":"20","author":"McShefferty","year":"2016","journal-title":"Trends Hear"},{"issue":"1","key":"ooi240096r27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1001\/jamaoto.2021.2769","article-title":"Association of bone conduction devices for single-sided sensorineural deafness with quality of life: a systematic review and meta-analysis.","volume":"148","author":"Hampton","year":"2022","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"1","key":"ooi240096r28","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00405-021-06634-7","article-title":"Bone-anchored hearing system, contralateral routing of signals hearing aid or cochlear implant: what is best in single-sided deafness?","volume":"279","author":"Jakob","year":"2022","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["JAMA Otolaryngology\u2013Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/articlepdf\/2829347\/jamaotolaryngology_van_heteren_2025_oi_240096_1740587388.10972.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T11:04:24Z","timestamp":1741863864000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/2829347"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoto.2024.4760","relation":{},"ISSN":["2168-6181"],"issn-type":[{"value":"2168-6181","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,1]]}}}