{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:29:51Z","timestamp":1789655391439,"version":"4.0.1"},"reference-count":37,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:sec id=\"ab-ooi240105-4\"><jats:title>Importance<\/jats:title><jats:p>The standard of care for patients with oral cavity squamous cell carcinoma (OCSCC) is generally primary surgical resection with or without adjuvant therapy (AT), based on pathological factors. Identifying preoperative factors that are associated with the receipt of AT may enhance treatment planning.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi240105-5\"><jats:title>Objective<\/jats:title><jats:p>To identify preoperative patient and tumor factors associated with receiving AT, either radiation therapy (RT) or chemoradiation therapy (CRT), in patients with OCSCC.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi240105-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This cohort study, spanning January 2005 to December 2019 at 9 academic centers in Canada, was conducted as part of the Canadian Head &amp;amp;amp; Neck Collaborative Research Initiative, a national network of head and neck surgical oncologists. Participants included patients with oral cavity cancer who underwent surgery. The data analysis was performed in March 2024.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi240105-7\"><jats:title>Exposures<\/jats:title><jats:p>Preoperative variables, including demographics (age, sex, smoking history, and Charlson Comorbidity Index [CCI]) and tumor characteristics (clinical T and N stage, biopsy grade, tumor size).<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi240105-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The main outcomes were the receipt of AT vs surgery alone; the type of AT, either RT or CRT; and the presence of a strong pathologic indicator for AT.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi240105-9\"><jats:title>Results<\/jats:title><jats:p>Of the 3980 patients, 2438 underwent surgery alone (61%) and 1542 received AT (39%). Of these, 1907 (48%) had a strong pathologic indicator for AT. The mean (SD) age was 63 (13) years, and 1498 participants (38%) were female. On multivariable analysis, factors independently associated with AT included being older than 65 years (odds ratio [OR], 0.50 [95% CI, 0.38-0.64]), CCI of 4 or higher (OR, 1.83 [95% CI, 1.26-2.65]), previous head and neck cancer (OR, 0.40 [95% CI, 0.26-0.62]), maxillary alveolus (OR, 2.16 [95% CI, 1.11-4.22]) and retromolar trigone (OR, 1.85 [95% CI, 1.04-3.29) subsites, tumor dimension (OR, 1.35 [95% CI, 1.22-1.50] per cm), increasing clinical T and N stages, and worse grade on biopsy (poorly differentiated: OR, 1.89 [95% CI, 1.25-2.84]). Among those receiving AT, poorly differentiated grade (OR, 2.40 [95% CI, 1.34-4.30]) and advanced N stage were associated with CRT rather than RT. Among patients with strong pathologic indicators for AT, factors associated with not receiving AT included age, CCI, grade, stage, and tumor dimension. The prediction model showed good discriminatory power (area under the receiver operating characteristic curve, 0.84 [95% CI, 0.82-0.86]).<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi240105-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The results of this cohort study suggest that preoperative variables can help to identify patients with OCSCC who are more likely to receive AT, despite many factors not being predictable until the postoperative period. Early identification of patients at high risk may improve treatment planning and reduce delays in initiating AT, potentially enhancing patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamaoto.2024.5250","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T18:48:21Z","timestamp":1743101301000},"page":"466","source":"Crossref","is-referenced-by-count":4,"title":["Preoperative Clinical and Tumor Factors Associated With Adjuvant Therapy for Oral Cavity Cancer"],"prefix":"10.1001","volume":"151","author":[{"given":"Gabriel S.","family":"Dayan","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houda","family":"Bahig","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Centre 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