{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:00:09Z","timestamp":1793073609558,"version":"4.5.0"},"reference-count":55,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:sec id=\"ab-ooi250004-4\"><jats:title>Importance<\/jats:title><jats:p>Middle ear optical coherence tomography (OCT) imaging in patients has not previously been directly compared with a standard of care clinical 3-dimensional imaging technology, such as computed tomography (CT).<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi250004-5\"><jats:title>Objective<\/jats:title><jats:p>To qualitatively compare the capabilities of middle ear OCT with CT in normal and pathological ears on representative slices in coregistered OCT and CT datasets.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi250004-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This case series included 3 patients and 3 ears: 1 normal middle ear, 1 ear affected by traumatic injury, and 1 ear with cholesteatoma. The ears were imaged with both OCT and high-resolution clinical temporal bone CT. Participants were drawn from the patient population of a tertiary otology clinic. CT and OCT images were aligned using rigid coregistration with manual landmark selection. Data were collected from January 2022 to April 2023, and data were analyzed from February 2022 to December 2023.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi250004-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Images were analyzed qualitatively for field of view (FOV), resolution, shadowing, artifacts, soft tissue and bony tissue contrast, and presentation of diagnostically important features.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi250004-8\"><jats:title>Results<\/jats:title><jats:p>In the 3 imaged ears, OCT was capable of visualizing many of the important features indicative of middle ear pathology. Compared with CT, OCT exhibited a limited FOV largely confined to the mesotympanum and subject to shadowing from bony structures. However, OCT could resolve soft tissue features that were not readily apparent in the CT images to have a higher resolution than CT and to provide excellent anatomical fidelity with CT, which allowed OCT images to be accurately coregistered with CT images.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ooi250004-9\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>In this case series, while OCT was not capable of replacing CT due to its limited FOV and inability to image through thick bony tissues, it visualized signs of pathology, including some soft tissue features, that are difficult to visualize with CT. Given OCT\u2019s ability to image in real time, its compatibility with in-office imaging, and its lack of ionizing radiation, it may, despite its limitations compared with CT, be an appealing imaging modality for many applications in middle ear diagnostics. <\/jats:p><\/jats:sec>","DOI":"10.1001\/jamaoto.2025.0043","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T21:16:18Z","timestamp":1743801378000},"page":"476","source":"Crossref","is-referenced-by-count":7,"title":["Fusion of Middle Ear Optical Coherence Tomography and Computed Tomography"],"prefix":"10.1001","volume":"151","author":[{"given":"Junzhe","family":"Wang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floor","family":"Couvreur","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, AZ Sint-Jan Brugge Hospital, Bruges, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Farrell","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma","family":"Ghedia","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nael","family":"Shoman","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B. 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