{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:10:13Z","timestamp":1786975813494,"version":"build-2736575974"},"reference-count":51,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Otolaryngol Head Neck Surg"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"\n Importance<\/jats:title>\n Age-related hearing loss (presbycusis) affects more than 50% of individuals 70 years or older and is associated with communication difficulty, social isolation, and cognitive decline. Microvascular and inflammatory conditions are known to affect peripheral and central auditory processes; as such, aspirin may have an important role in slowing age-related dysfunction.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate whether low-dose aspirin affects the rate of central auditory pathway degeneration in older adults.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This study was embedded within the parent Aspirin in Reducing Events in the Elderly (ASPREE) Project, which was a randomized, placebo-controlled trial that explored aspirin effects on healthy aging. Enrollment occurred after randomization. It was conducted at Monash Biomedical Imaging Center (Melbourne, Victoria, Australia) from 2014 to 2019. Eligible adults aged 70 years or older at baseline received either 100 mg daily of enteric-coated aspirin or a matching placebo. Individuals participated in the drug trial for at least 2.5 years and then underwent 1-year and 2-year posttrial reviews. Auditory assessment was carried out at baseline and 18, 36, 48, and 60 months. Data were analyzed from 2025 to 2026.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Type and severity of auditory dysfunction were evaluated via electrophysiologic (cortical auditory evoked potentials) and perceptual (speech-in-noise) assessment. Group outcomes were compared using mixed-linear regression models that adjusted for participants\u2019 age and hearing level.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 124 individuals (mean [SD] age, 72.8 [3.5] years; 60 female individuals [48.4%]), 61 (49.2%) received aspirin and 63 (50.8%) received placebo. Cortical response latencies increased over the course of study (N1: 1.3 milliseconds per year; P2: 0.9 milliseconds per year), but there was no aspirin effect. Similarly, N1\/P2 amplitudes decreased over time (0.2 uV per year). In this case, there was a main effect for aspirin, but there was no aspirin\/time point interaction, suggesting that the result was due to a group difference at baseline that was maintained throughout the study. Binaural speech perception deteriorated for listening conditions for which target and noise sources were spatially separated, with reception thresholds decreasing by 0.1 dB per year. When speech and noise were colocated, there was no change. There was no aspirin effect for any condition.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n This substudy of randomized clinical trial showed that there was no clinically important effect of low-dose aspirin on central presbycusis. However, more investigation (of aspirin and other treatment options) is warranted, as the longitudinal findings revealed substantial auditory neural and functional hearing deterioration over a relatively short (5-year) period in healthy older adults.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n anzctr.org.au Identifier:\n ACTRN12614000496617<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamaoto.2026.0338","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:00:31Z","timestamp":1775746831000},"page":"560","source":"Crossref","is-referenced-by-count":1,"title":["Low-Dose Aspirin and Central Presbycusis"],"prefix":"10.1001","volume":"152","author":[{"given":"Gary","family":"Rance","sequence":"first","affiliation":[{"name":"The University of Melbourne, Department of Audiology and Speech Pathology, Carlton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Zanin","sequence":"additional","affiliation":[{"name":"The University of Melbourne, Department of Audiology and Speech Pathology, Carlton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlene J.","family":"Britt","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cammie","family":"Tran","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"McNeil","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"key":"ooi260012r1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2147\/CIA.S26059","article-title":"The impact of hearing loss on the quality of life of elderly adults.","volume":"7","author":"Ciorba","year":"2012","journal-title":"Clin Interv Aging"},{"issue":"9","key":"ooi260012r2","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1093\/gerona\/gls066","article-title":"Cognitive, health, and sociodemographic predictors of longitudinal decline in hearing acuity among older adults.","volume":"67","author":"Kiely","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"7","key":"ooi260012r3","doi-asserted-by":"publisher","first-page":"e2326320","DOI":"10.1001\/jamanetworkopen.2023.26320","article-title":"Prevalence of hearing loss and hearing aid use among US Medicare beneficiaries aged 71 years and older.","volume":"6","author":"Reed","year":"2023","journal-title":"JAMA Netw Open"},{"key":"ooi260012r4","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1060172","article-title":"Aging alters across-hemisphere cortical dynamics during binaural temporal processing.","volume":"16","author":"Eddins","year":"2023","journal-title":"Front Neurosci"},{"issue":"9491","key":"ooi260012r5","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbycusis.","volume":"366","author":"Gates","year":"2005","journal-title":"Lancet"},{"issue":"4","key":"ooi260012r6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0197-4580(84)90005-8","article-title":"Age-related differences in recovery cycle of auditory evoked potentials.","volume":"5","author":"Papanicolaou","year":"1984","journal-title":"Neurobiol Aging"},{"issue":"3","key":"ooi260012r7","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3766\/jaaa.15.3.5","article-title":"Speech evoked cortical potentials: effects of age and stimulus presentation rate.","volume":"15","author":"Tremblay","year":"2004","journal-title":"J Am Acad Audiol"},{"issue":"1-2","key":"ooi260012r8","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.heares.2006.10.009","article-title":"Temporal jitter disrupts speech intelligibility: a simulation of auditory aging.","volume":"223","author":"Pichora-Fuller","year":"2007","journal-title":"Hear Res"},{"issue":"6","key":"ooi260012r9","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1152\/jn.00560.2016","article-title":"Reduced temporal processing in older, normal-hearing listeners evident from electrophysiological responses to shifts in interaural time difference.","volume":"116","author":"Ozmeral","year":"2016","journal-title":"J Neurophysiol"},{"issue":"8","key":"ooi260012r10","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3766\/jaaa.23.8.5","article-title":"Central presbycusis: a review and evaluation of the evidence.","volume":"23","author":"Humes","year":"2012","journal-title":"J Am Acad Audiol"},{"issue":"1-2","key":"ooi260012r11","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.heares.2007.01.007","article-title":"The role of auditory cortex in the formation of auditory streams.","volume":"229","author":"Micheyl","year":"2007","journal-title":"Hear Res"},{"issue":"1","key":"ooi260012r12","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S1474-4422(05)70284-2","article-title":"Risk of dementia in diabetes mellitus: a systematic review.","volume":"5","author":"Biessels","year":"2006","journal-title":"Lancet Neurol"},{"issue":"5","key":"ooi260012r13","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1097\/MAO.0000000000000293","article-title":"Histopathologic changes in the cochlea associated with diabetes mellitus\u2013a review.","volume":"35","author":"Akinpelu","year":"2014","journal-title":"Otol Neurotol"},{"issue":"4","key":"ooi260012r14","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1097\/AUD.0000000000000137","article-title":"Hearing impairment in relation to severity of diabetes in a veteran cohort.","volume":"36","author":"Konrad-Martin","year":"2015","journal-title":"Ear Hear"},{"issue":"3","key":"ooi260012r15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3109\/00206099009072844","article-title":"Hearing disorders in patients with insulin-dependent diabetes mellitus.","volume":"29","author":"Parving","year":"1990","journal-title":"Audiology"},{"issue":"3","key":"ooi260012r16","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1002\/lary.24354","article-title":"Is type 2 diabetes mellitus associated with alterations in hearing? a systematic review and meta-analysis.","volume":"124","author":"Akinpelu","year":"2014","journal-title":"Laryngoscope"},{"issue":"1","key":"ooi260012r17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/lary.20636","article-title":"Diabetes-related changes in auditory brainstem responses.","volume":"120","author":"Konrad-Martin","year":"2010","journal-title":"Laryngoscope"},{"issue":"8","key":"ooi260012r18","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1007\/s00415-014-7371-2","article-title":"Auditory neuropathy in individuals with type 1 diabetes.","volume":"261","author":"Rance","year":"2014","journal-title":"J Neurol"},{"issue":"1-2","key":"ooi260012r19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.heares.2008.08.001","article-title":"Strial microvascular pathology and age-associated endocochlear potential decline in NOD congenic mice.","volume":"244","author":"Ohlemiller","year":"2008","journal-title":"Hear Res"},{"issue":"10","key":"ooi260012r20","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1161\/01.CIR.0000027816.54430.96","article-title":"Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice.","volume":"106","author":"Cyrus","year":"2002","journal-title":"Circulation"},{"issue":"5","key":"ooi260012r21","doi-asserted-by":"publisher","first-page":"4020","DOI":"10.1121\/1.5132545","article-title":"Inflammation associated with noise-induced hearing loss.","volume":"146","author":"Frye","year":"2019","journal-title":"J Acoust Soc Am"},{"issue":"1","key":"ooi260012r22","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12974-023-02996-3","article-title":"Oxidative stress and inflammation cause auditory system damage via glial cell activation and dysregulated expression of gap junction proteins in an experimental model of styrene-induced oto\/neurotoxicity.","volume":"21","author":"Paciello","year":"2024","journal-title":"J Neuroinflammation"},{"issue":"1","key":"ooi260012r23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1177\/0194599814553930","article-title":"Ubiquitous aspirin: a systematic review of its impact on sensorineural hearing loss.","volume":"152","author":"Kyle","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ooi260012r24","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2025.109217","article-title":"Dose-response relationship of aspirin and sudden sensorineural hearing loss risk in type 2 diabetes: aspirin dosage on SSNHL risk in T2D.","volume":"459","author":"Liu","year":"2025","journal-title":"Hear Res"},{"issue":"7","key":"ooi260012r25","doi-asserted-by":"publisher","first-page":"e2424373","DOI":"10.1001\/jamanetworkopen.2024.24373","article-title":"Low-dose aspirin and progression of age-related hearing loss: a secondary analysis of the ASPREE randomized clinical trial.","volume":"7","author":"Clark","year":"2024","journal-title":"JAMA Netw Open"},{"issue":"2","key":"ooi260012r26","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.cct.2013.09.014","article-title":"Study design of Aspirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial.","volume":"36","author":"Group","year":"2013","journal-title":"Contemp Clin Trials"},{"issue":"2","key":"ooi260012r27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/AUD.0b013e318031267f","article-title":"Development of the listening in spatialized noise-sentences test (LISN-S).","volume":"28","author":"Cameron","year":"2007","journal-title":"Ear Hear"},{"issue":"8","key":"ooi260012r28","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1001\/archotol.1990.01870080054015","article-title":"Cochlear microcirculation in young and old gerbils.","volume":"116","author":"Prazma","year":"1990","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"1-2","key":"ooi260012r29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.heares.2011.08.006","article-title":"Physiopathology of the cochlear microcirculation.","volume":"282","author":"Shi","year":"2011","journal-title":"Hear Res"},{"issue":"11","key":"ooi260012r30","doi-asserted-by":"publisher","first-page":"2618","DOI":"10.1161\/STROKEAHA.110.593327","article-title":"Tumor necrosis factor-a enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling.","volume":"41","author":"Scherer","year":"2010","journal-title":"Stroke"},{"issue":"9","key":"ooi260012r31","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1093\/oxfordjournals.aje.a009713","article-title":"Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin.","volume":"148","author":"Cruickshanks","year":"1998","journal-title":"Am J Epidemiol"},{"issue":"1","key":"ooi260012r32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00003446-200502000-00001","article-title":"Longitudinal study of pure-tone thresholds in older persons.","volume":"26","author":"Lee","year":"2005","journal-title":"Ear Hear"},{"issue":"4","key":"ooi260012r33","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3766\/jaaa.19.4.2","article-title":"Changes in hearing thresholds over 10 years in older adults.","volume":"19","author":"Wiley","year":"2008","journal-title":"J Am Acad Audiol"},{"issue":"4","key":"ooi260012r34","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/j.1469-8986.1987.tb00311.x","article-title":"The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure.","volume":"24","author":"N\u00e4\u00e4t\u00e4nen","year":"1987","journal-title":"Psychophysiology"},{"issue":"7","key":"ooi260012r35","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1097\/MAO.0b013e3182659b1e","article-title":"Cortical auditory evoked potential in aging: effects of stimulus intensity and noise.","volume":"33","author":"Kim","year":"2012","journal-title":"Otol Neurotol"},{"issue":"8","key":"ooi260012r36","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1017\/S0022215100067815","article-title":"Changes in auditory evoked response with intensity.","volume":"81","author":"Beagley","year":"1967","journal-title":"J Laryngol Otol"},{"issue":"1-2","key":"ooi260012r37","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.heares.2007.01.008","article-title":"Correlated neural activity as the driving force for functional changes in auditory cortex.","volume":"229","author":"Eggermont","year":"2007","journal-title":"Hear Res"},{"issue":"1","key":"ooi260012r38","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0168-5597(86)90037-7","article-title":"Latency variability and temporal interrelationships of the auditory event-related potentials (N1, P2, N2, and P3) in normal subjects.","volume":"65","author":"Michalewski","year":"1986","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"9","key":"ooi260012r39","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1111\/dme.13086","article-title":"Functional hearing deficits in children with type 1 diabetes.","volume":"33","author":"Rance","year":"2016","journal-title":"Diabet Med"},{"issue":"4","key":"ooi260012r40","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000255341","article-title":"Auditory perception in individuals with Friedreich\u2019s ataxia.","volume":"15","author":"Rance","year":"2010","journal-title":"Audiol Neurootol"},{"issue":"Pt 11","key":"ooi260012r41","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1093\/brain\/awv270","article-title":"Pathophysiological mechanisms and functional hearing consequences of auditory neuropathy.","volume":"138","author":"Rance","year":"2015","journal-title":"Brain"},{"issue":"1","key":"ooi260012r42","doi-asserted-by":"publisher","DOI":"10.4081\/audiores.2011.e4","article-title":"Auditory temporal processing and aging: implications for speech understanding of older people.","volume":"1","author":"Gordon-Salant","year":"2011","journal-title":"Audiol Res"},{"key":"ooi260012r43","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.heares.2018.05.001","article-title":"How aging impacts the encoding of binaural cues and the perception of auditory space.","volume":"369","author":"Eddins","year":"2018","journal-title":"Hear Res"},{"issue":"2","key":"ooi260012r44","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1152\/jn.00090.2019","article-title":"Electrophysiological responses to lateral shifts are not consistent with opponent-channel processing of interaural level differences.","volume":"122","author":"Ozmeral","year":"2019","journal-title":"J Neurophysiol"},{"issue":"12","key":"ooi260012r46","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1080\/14992027.2019.1641752","article-title":"The relationship between peripheral hearing loss and higher order listening function on cognition in older Australians.","volume":"58","author":"Nixon","year":"2019","journal-title":"Int J Audiol"},{"issue":"1","key":"ooi260012r47","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/AUD.0b013e3182617f94","article-title":"The effects of hearing impairment and aging on spatial processing.","volume":"34","author":"Glyde","year":"2013","journal-title":"Ear Hear"},{"issue":"1","key":"ooi260012r48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/0194599812446282","article-title":"Central presbycusis: an emerging view.","volume":"147","author":"Gates","year":"2012","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"ooi260012r49","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/AUD.0000000000000096","article-title":"Speech-in-speech listening on the LiSN-S test by older adults with good audiograms depends on cognition and hearing acuity at high frequencies.","volume":"36","author":"Besser","year":"2015","journal-title":"Ear Hear"},{"issue":"1","key":"ooi260012r50","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/00003446-199402000-00002","article-title":"Noise, amplification, and compression: considerations of three main issues in hearing aid design.","volume":"15","author":"Plomp","year":"1994","journal-title":"Ear Hear"},{"issue":"7","key":"ooi260012r51","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1007\/s10803-017-3114-4","article-title":"Reducing listening-related stress in school-aged children with autism spectrum disorder.","volume":"47","author":"Rance","year":"2017","journal-title":"J Autism Dev Disord"},{"key":"ooi260012r45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-319-51662-2_9","volume-title":"The Auditory System at the Cocktail Party","author":"Pichora-Fuller","year":"2017"}],"container-title":["JAMA Otolaryngology\u2013Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/articlepdf\/2847493\/jamaotolaryngology_rance_2026_oi_260012_1780332699.93242.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:00:56Z","timestamp":1781190056000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/2847493"}},"subtitle":["A Substudy of the ASPREE Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamaoto.2026.0338","relation":{},"ISSN":["2168-6181"],"issn-type":[{"value":"2168-6181","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,1]]}}}