{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:33:13Z","timestamp":1793493193286,"version":"4.5.0"},"reference-count":32,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Pediatr"],"published-print":{"date-parts":[[2020,1,1]]},"DOI":"10.1001\/jamapediatrics.2019.4011","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T11:30:54Z","timestamp":1573471854000},"page":"48","source":"Crossref","is-referenced-by-count":204,"title":["Two-Year Neurodevelopmental Outcomes After Mild Hypoxic Ischemic Encephalopathy in the Era of Therapeutic Hypothermia"],"prefix":"10.1001","volume":"174","author":[{"given":"Mikael","family":"Finder","sequence":"first","affiliation":[{"name":"Division of Paediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden"},{"name":"Neonatal Department, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine B.","family":"Boylan","sequence":"additional","affiliation":[{"name":"INFANT Research Centre, Ireland, University College Cork, Cork, Ireland"},{"name":"Department of Paediatrics and Child Health, Cork University Hospital, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"Twomey","sequence":"additional","affiliation":[{"name":"INFANT Research Centre, Ireland, University College Cork, Cork, Ireland"},{"name":"Department of Paediatrics and Child Health, Cork University Hospital, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Ahearne","sequence":"additional","affiliation":[{"name":"INFANT Research Centre, Ireland, University College Cork, Cork, Ireland"},{"name":"Department of Paediatrics and Child Health, Cork University Hospital, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre M.","family":"Murray","sequence":"additional","affiliation":[{"name":"INFANT Research Centre, Ireland, University College Cork, Cork, Ireland"},{"name":"Department of Paediatrics and Child Health, Cork University Hospital, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boubou","family":"Hallberg","sequence":"additional","affiliation":[{"name":"Division of Paediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden"},{"name":"Neonatal Department, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"8","key":"poi190076r1","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/apa.1995.84.issue-8","article-title":"Birth asphyxia: incidence, clinical course and outcome in a Swedish population.","volume":"84","author":"Thornberg","year":"1995","journal-title":"Acta Paediatr"},{"issue":"1","key":"poi190076r2","first-page":"65","article-title":"Low 5-minute Apgar score: a population-based register study of 1 million term births.","volume":"98","author":"Thorngren-Jerneck","year":"2001","journal-title":"Obstet Gynecol"},{"issue":"2","key":"poi190076r3","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/ana.v72.2","article-title":"Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathy.","volume":"72","author":"Volpe","year":"2012","journal-title":"Ann Neurol"},{"issue":"6","key":"poi190076r4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy.","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum Dev"},{"issue":"1","key":"poi190076r5","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy.","volume":"1","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"poi190076r6","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes.","volume":"371","author":"Azzopardi","year":"2014","journal-title":"N Engl J Med"},{"issue":"10","key":"poi190076r7","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study.","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch Neurol"},{"issue":"5","key":"poi190076r8","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/S0022-3476(89)80132-5","article-title":"School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term.","volume":"114","author":"Robertson","year":"1989","journal-title":"J Pediatr"},{"issue":"8","key":"poi190076r9","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/j.1469-8749.1997.tb07478.x","article-title":"Intrapartum fetal asphyxia and the occurrence of minor deficits in 4- to 8-year-old children.","volume":"39","author":"Handley-Derry","year":"1997","journal-title":"Dev Med Child Neurol"},{"issue":"4","key":"poi190076r10","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0659","article-title":"Early EEG grade and outcome at 5 years after mild neonatal hypoxic ischemic encephalopathy.","volume":"138","author":"Murray","year":"2016","journal-title":"Pediatrics"},{"issue":"1","key":"poi190076r11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1001\/jamapediatrics.2017.3044","article-title":"Mild neonatal encephalopathy: how, when, and how much to treat?","volume":"172","author":"Lodygensky","year":"2018","journal-title":"JAMA Pediatr"},{"issue":"6","key":"poi190076r12","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/s41390-018-0174-x","article-title":"Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months.","volume":"84","author":"Chalak","year":"2018","journal-title":"Pediatr Res"},{"issue":"2","key":"poi190076r13","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1055\/s-00000009","article-title":"Newborns referred for therapeutic hypothermia: association between initial degree of encephalopathy and severity of brain injury (what about the newborns with mild encephalopathy on admission?).","volume":"33","author":"Gagne-Loranger","year":"2016","journal-title":"Am J Perinatol"},{"key":"poi190076r14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.earlhumdev.2018.02.007","article-title":"Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome: a systematic review.","volume":"120","author":"Conway","year":"2018","journal-title":"Early Hum Dev"},{"issue":"5","key":"poi190076r17","doi-asserted-by":"publisher","first-page":"721","DOI":"10.3109\/14767058.2015.1015984","article-title":"Hypoxic ischemic encephalopathy in newborns linked to placental and umbilical cord abnormalities.","volume":"29","author":"Nasiell","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2","key":"poi190076r18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jpeds.2015.04.060","article-title":"Downregulation of umbilical cord blood levels of miR-374a in neonatal hypoxic ischemic encephalopathy.","volume":"167","author":"Looney","year":"2015","journal-title":"J Pediatr"},{"issue":"5","key":"poi190076r19","doi-asserted-by":"publisher","first-page":"F493","DOI":"10.1136\/archdischild-2018-315624","article-title":"Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: a multicentre experience.","volume":"104","author":"Rennie","year":"2019","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"8472","key":"poi190076r20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0140-6736(86)90718-X","article-title":"Comparison of two methods of predicting outcome in perinatal asphyxia.","volume":"1","author":"Levene","year":"1986","journal-title":"Lancet"},{"issue":"1","key":"poi190076r21","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2431-8-17","article-title":"The TOBY study: whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial.","volume":"8","author":"Azzopardi","year":"2008","journal-title":"BMC Pediatr"},{"issue":"17","key":"poi190076r22","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1001\/jama.2013.3786","article-title":"Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden.","volume":"309","author":"Serenius","year":"2013","journal-title":"JAMA"},{"issue":"16","key":"poi190076r23","doi-asserted-by":"publisher","first-page":"S516","DOI":"10.1161\/CIRCULATIONAHA.110.971127","article-title":"Part 11: neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.","volume":"122","author":"Perlman","year":"2010","journal-title":"Circulation"},{"issue":"4","key":"poi190076r24","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1469-8749.1985.tb04571.x","article-title":"Term infants with hypoxic-ischemic encephalopathy: outcome at 3.5 years.","volume":"27","author":"Robertson","year":"1985","journal-title":"Dev Med Child Neurol"},{"issue":"1","key":"poi190076r25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jpeds.2012.06.042","article-title":"Short-term outcomes of newborns with perinatal acidemia who are not eligible for systemic hypothermia therapy.","volume":"162","author":"DuPont","year":"2013","journal-title":"J Pediatr"},{"issue":"1","key":"poi190076r26","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1080\/87565641.2011.581320","article-title":"Specific memory impairment following neonatal encephalopathy in term-born children.","volume":"37","author":"van Handel","year":"2012","journal-title":"Dev Neuropsychol"},{"issue":"3","key":"poi190076r27","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1093\/jpepsy\/jsp049","article-title":"Behavioral outcome in children with a history of neonatal encephalopathy following perinatal asphyxia.","volume":"35","author":"van Handel","year":"2010","journal-title":"J Pediatr Psychol"},{"issue":"2","key":"poi190076r28","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jpeds.2010.02.016","article-title":"Serial MRI and neurodevelopmental outcome in 9- to 10-year-old children with neonatal encephalopathy.","volume":"157","author":"van Kooij","year":"2010","journal-title":"J Pediatr"},{"key":"poi190076r29","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jpeds.2017.03.065","article-title":"The frequency and severity of magnetic resonance imaging abnormalities in infants with mild neonatal encephalopathy.","volume":"187","author":"Walsh","year":"2017","journal-title":"J Pediatr"},{"issue":"5","key":"poi190076r30","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1080\/00016340801996622","article-title":"Moderate neonatal encephalopathy: pre- and perinatal risk factors and long-term outcome.","volume":"87","author":"Lindstr\u00f6m","year":"2008","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"poi190076r31","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/apa.12784","article-title":"Cooling neonates who do not fulfil the standard cooling criteria: short- and long-term outcomes.","volume":"104","author":"Smit","year":"2015","journal-title":"Acta Paediatr"},{"issue":"4","key":"poi190076r32","doi-asserted-by":"publisher","first-page":"F388","DOI":"10.1136\/archdischild-2017-313320","article-title":"Therapeutic hypothermia in mild neonatal encephalopathy: a national survey of practice in the UK.","volume":"103","author":"Oliveira","year":"2018","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"poi190076r15","unstructured":"ClinicalTrials.gov. BiHiVE2 Study: The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy. NCT02019147. https:\/\/clinicaltrials.gov\/ct2\/results?cond=NCT02019147&term=&cntry=&state=&city=&di. Accessed September 22, 2019."},{"key":"poi190076r16","unstructured":"ClinicalTrials.gov. ANSeR: The Algorithm for Neonatal Seizure Recognition Study. NCT02160171. https:\/\/clinicaltrials.gov\/ct2\/results?cond=NCT02160171&term=&cntry=&state=&city=&dist. Accessed September 22, 2019."}],"container-title":["JAMA Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/articlepdf\/2754822\/jamapediatrics_finder_2019_oi_190076.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T11:00:51Z","timestamp":1579604451000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/fullarticle\/2754822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapediatrics.2019.4011","relation":{},"ISSN":["2168-6203"],"issn-type":[{"value":"2168-6203","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1,1]]}}}