{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:14Z","timestamp":1792794674155,"version":"4.5.0"},"reference-count":44,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Pediatr"],"DOI":"10.1001\/jamapediatrics.2022.0152","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T11:35:19Z","timestamp":1648467319000},"page":"e220152","source":"Crossref","is-referenced-by-count":22,"title":["Effects of Freshly Irradiated vs Irradiated and Stored Red Blood Cell Transfusion on Cerebral Oxygenation in Preterm Infants"],"prefix":"10.1001","volume":"176","author":[{"given":"Maria","family":"Saito-Benz","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health, University of Otago, Wellington, New Zealand"},{"name":"Neonatal Intensive Care Unit, Wellington Regional Hospital, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Bennington","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Wellington Regional Hospital, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint L.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, University of Otago, Wellington, New Zealand"},{"name":"Centre for Translational Physiology, University of Otago, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Murphy","sequence":"additional","affiliation":[{"name":"New Zealand Blood Service, Wellington Regional Hospital, Wellington, New Zealand"},{"name":"School of Medical Science, University College, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Flanagan","sequence":"additional","affiliation":[{"name":"New Zealand Blood Service, Wellington Regional Hospital, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederica","family":"Steiner","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Wellington Regional Hospital, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Faculty of Science, Liverpool John Moores University, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, University of Otago, Wellington, New Zealand"},{"name":"Neonatal Intensive Care Unit, Wellington Regional Hospital, Wellington, New Zealand"},{"name":"Centre for Translational Physiology, University of Otago, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"issue":"4","key":"poi220007r1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1053\/j.semperi.2012.04.004","article-title":"International survey of transfusion practices for extremely premature infants.","volume":"36","author":"Guill\u00e9n","year":"2012","journal-title":"Semin Perinatol"},{"issue":"2","key":"poi220007r2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0022-3476(00)70105-3","article-title":"Changing practices of red blood cell transfusions in infants with birth weights less than 1000 g.","volume":"136","author":"Maier","year":"2000","journal-title":"J Pediatr"},{"issue":"5","key":"poi220007r3","doi-asserted-by":"publisher","first-page":"F411","DOI":"10.1136\/archdischild-2014-307716","article-title":"Red cell and platelet transfusions in neonates: a population-based study.","volume":"100","author":"Bowen","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"11","key":"poi220007r4","doi-asserted-by":"publisher","DOI":"10.1542\/neo.9-11-e520","article-title":"Pathophysiology of anemia during the neonatal period, including anemia of prematurity.","volume":"9","author":"Widness","year":"2008","journal-title":"Neoreviews"},{"issue":"3","key":"poi220007r5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.bjhh.2015.03.001","article-title":"Evaluation of the effectiveness of packed red blood cell irradiation by a linear accelerator.","volume":"37","author":"Olivo","year":"2015","journal-title":"Rev Bras Hematol Hemoter"},{"issue":"3","key":"poi220007r6","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1182\/blood-2015-01-620872","article-title":"A systematic review of transfusion-associated graft-versus-host disease.","volume":"126","author":"Kopolovic","year":"2015","journal-title":"Blood"},{"issue":"10","key":"poi220007r7","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.5858\/arpa.2015-0167-CP","article-title":"Survey of irradiation practice for the prevention of transfusion-associated graft-versus-host disease.","volume":"140","author":"Pritchard","year":"2016","journal-title":"Arch Pathol Lab Med"},{"issue":"9","key":"poi220007r11","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1111\/trf.2018.58.issue-9","article-title":"Storage after gamma irradiation affects in vivo oxygen delivery capacity of transfused red blood cells in preterm infants.","volume":"58","author":"Saito-Benz","year":"2018","journal-title":"Transfusion"},{"issue":"3","key":"poi220007r12","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.transci.2014.02.002","article-title":"Serial assessment of biochemical changes in irradiated red blood cells.","volume":"50","author":"Patidar","year":"2014","journal-title":"Transfus Apher Sci"},{"issue":"7","key":"poi220007r13","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.7754\/Clin.Lab.2015.151127","article-title":"Influence of irradiation on leukodepleted small unit red blood cell (RBC) bags for infant transfusion in additive solution SAG-M.","volume":"62","author":"Hauck-Dlimi","year":"2016","journal-title":"Clin Lab"},{"issue":"3","key":"poi220007r14","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/vox.2011.100.issue-3","article-title":"Influence of late irradiation on the in vitro RBC storage variables of leucoreduced RBCs in SAGM additive solution.","volume":"100","author":"Zimmermann","year":"2011","journal-title":"Vox Sang"},{"issue":"2","key":"poi220007r15","first-page":"176","article-title":"Deformability and viability of irradiated red cells.","volume":"43","author":"Reverberi","year":"2007","journal-title":"Ann Ist Super Sanita"},{"issue":"5","key":"poi220007r16","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1111\/vox.2017.112.issue-5","article-title":"Early ?-irradiation and subsequent storage of red cells in SAG-M additive solution potentiate energy imbalance, microvesiculation and susceptibility to stress-induced apoptotic cell death.","volume":"112","author":"Qadri","year":"2017","journal-title":"Vox Sang"},{"issue":"5","key":"poi220007r17","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00277-013-1944-5","article-title":"The effect of gamma radiation on the lipid profile of irradiated red blood cells.","volume":"93","author":"Maia","year":"2014","journal-title":"Ann Hematol"},{"issue":"7","key":"poi220007r18","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s00277-013-1719-z","article-title":"The effect of ?-radiation on the hemoglobin of stored red blood cells: the involvement of oxidative stress in hemoglobin conformation.","volume":"92","author":"de Oliveira","year":"2013","journal-title":"Ann Hematol"},{"issue":"3","key":"poi220007r19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jpeds.2006.05.011","article-title":"The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants.","volume":"149","author":"Kirpalani","year":"2006","journal-title":"J Pediatr"},{"issue":"20","key":"poi220007r21","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/(SICI)1097-0258(19971030)16:20<2349::AID-SIM667>3.0.CO;2-E","article-title":"Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data.","volume":"16","author":"Cnaan","year":"1997","journal-title":"Stat Med"},{"key":"poi220007r22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2202-11-5","article-title":"The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis?","volume":"11","author":"Lazic","year":"2010","journal-title":"BMC Neurosci"},{"issue":"7321","key":"poi220007r23","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1136\/bmj.323.7321.1123","article-title":"Statistics notes: analysing controlled trials with baseline and follow up measurements.","volume":"323","author":"Vickers","year":"2001","journal-title":"BMJ"},{"issue":"3","key":"poi220007r24","first-page":"216","article-title":"Effect of gamma irradiation on the in vivo recovery of stored red blood cells.","volume":"23","author":"Mintz","year":"1993","journal-title":"Ann Clin Lab Sci"},{"issue":"1","key":"poi220007r25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2141.1989.tb06286.x","article-title":"In vivo regeneration of red cell 2,3-diphosphoglycerate following transfusion of DPG-depleted AS-1, AS-3 and CPDA-1 red cells.","volume":"71","author":"Heaton","year":"1989","journal-title":"Br J Haematol"},{"issue":"4","key":"poi220007r26","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1182\/blood-2015-09-670950","article-title":"Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis.","volume":"127","author":"Alexander","year":"2016","journal-title":"Blood"},{"issue":"3","key":"poi220007r27","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/vox.12495","article-title":"Mortality outcomes in patients transfused with fresher versus older red blood cells: a meta-analysis.","volume":"112","author":"Chai-Adisaksopha","year":"2017","journal-title":"Vox Sang"},{"issue":"1","key":"poi220007r28","first-page":"27","article-title":"Red blood cell storage lesion: causes and potential clinical consequences.","volume":"17","author":"Yoshida","year":"2019","journal-title":"Blood Transfus"},{"issue":"2","key":"poi220007r29","first-page":"82","article-title":"Red blood cell storage: the story so far.","volume":"8","author":"D\u2019Alessandro","year":"2010","journal-title":"Blood Transfus"},{"issue":"3","key":"poi220007r30","first-page":"222","article-title":"Red blood cell storage time and transfusion: current practice, concerns and future perspectives.","volume":"15","author":"Garc\u00eda-Roa","year":"2017","journal-title":"Blood Transfus"},{"issue":"6","key":"poi220007r31","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1046\/j.1537-2995.1992.32692367195.x","article-title":"The effect of prestorage irradiation on posttransfusion red cell survival.","volume":"32","author":"Davey","year":"1992","journal-title":"Transfusion"},{"issue":"4","key":"poi220007r32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.siny.2008.02.009","article-title":"Neonatal anemia.","volume":"13","author":"Aher","year":"2008","journal-title":"Semin Fetal Neonatal Med"},{"issue":"1","key":"poi220007r33","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.siny.2015.12.001","article-title":"Anemia and transfusion in the neonate.","volume":"21","author":"Colombatti","year":"2016","journal-title":"Semin Fetal Neonatal Med"},{"issue":"11","key":"poi220007r34","article-title":"Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants.","author":"Whyte","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"poi220007r35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s40746-015-0021-9","article-title":"Anaemia in the premature infant and red blood cell transfusion: new approaches to an age-old problem.","volume":"1","author":"Andersen","year":"2015","journal-title":"Curr Treat Options Pediatr"},{"issue":"22","key":"poi220007r36","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1001\/jama.2019.17478","article-title":"Effect of fresh vs standard-issue red blood cell transfusions on multiple organ dysfunction syndrome in critically ill pediatric patients: a randomized clinical trial.","volume":"322","author":"Spinella","year":"2019","journal-title":"JAMA"},{"issue":"14","key":"poi220007r37","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1001\/2012.jama.11953","article-title":"Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial.","volume":"308","author":"Fergusson","year":"2012","journal-title":"JAMA"},{"issue":"5","key":"poi220007r38","doi-asserted-by":"crossref","first-page":"F352","DOI":"10.1136\/adc.2009.163592","article-title":"Cerebral tissue oxygen saturation and extraction in preterm infants before and after blood transfusion.","volume":"95","author":"van Hoften","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"10","key":"poi220007r39","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1111\/trf.15452","article-title":"Liberal hemoglobin threshold affects cerebral arterial pulsed Doppler and cardiac output, not cerebral tissue oxygenation: a prospective cohort study in anemic preterm infants.","volume":"59","author":"Jani","year":"2019","journal-title":"Transfusion"},{"issue":"1","key":"poi220007r40","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1186\/s13063-019-3756-y","article-title":"Detailed statistical analysis plan for the SafeBoosC III trial: a multinational randomised clinical trial assessing treatment guided by cerebral oxygenation monitoring versus treatment as usual in extremely preterm infants.","volume":"20","author":"Hansen","year":"2019","journal-title":"Trials"},{"key":"poi220007r41","doi-asserted-by":"crossref","first-page":"g7635","DOI":"10.1136\/bmj.g7635","article-title":"Cerebral near infrared spectroscopy oximetry in extremely preterm infants: phase II randomised clinical trial.","volume":"350","author":"Hyttel-Sorensen","year":"2015","journal-title":"BMJ"},{"issue":"27","key":"poi220007r43","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1056\/NEJMoa2020248","article-title":"Higher or lower hemoglobin transfusion thresholds for preterm infants.","volume":"383","author":"Kirpalani","year":"2020","journal-title":"N Engl J Med"},{"issue":"6","key":"poi220007r44","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1001\/jama.2020.10690","article-title":"Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: the ETTNO randomized clinical trial.","volume":"324","author":"Franz","year":"2020","journal-title":"JAMA"},{"key":"poi220007r8","volume-title":"European Directorate for the Quality of Medicines & Healthcare. Guide for the Preparation, Use and Quality Assurance of Blood Components: Recommendation No. R (95) 15","author":"European Committee (Partial Agreement) on Blood Transfusion","year":"2017"},{"key":"poi220007r10","volume-title":"Guidelines for Prevention of Transfusion-Associated Graft-Versus-Host Disease","author":"Australian and New Zealand Society of Blood Transfusion (ANZSBT) LDT","year":"2011"},{"key":"poi220007r9","unstructured":"Food and Drug Administration. Office of Blood Research and Review recommendations regarding license amendments and procedures for gamma irradiation of blood products. July 22, 1993. Accessed July 20, 2021. https:\/\/www.fda.gov\/files\/vaccines%2C%20blood%20%26%20biologics\/published\/Recommendations-Regarding-License-Amendments-and-Procedures-for-Gamma-Irradiation-of-Blood-Products.pdf."},{"key":"poi220007r20","unstructured":"Sealed Envelope. Randomisation and online databases for clinical trials. Accessed July 18, 2021. http:\/\/www.sealedenvelope.com"},{"key":"poi220007r42","unstructured":"Does near infra-red spectroscopy targeted use reduce adverse outcomes in extremely preterm infants? (NIRTURE trial). ANZCTR identifier: ACTRN12621000778886. Accessed July 18, 2021. https:\/\/anzctr.org.au\/ACTRN12621000778886.aspx"}],"container-title":["JAMA Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/articlepdf\/2790363\/jamapediatrics_saitobenz_2022_oi_220007_1651175670.97059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T11:03:29Z","timestamp":1651489409000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/fullarticle\/2790363"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapediatrics.2022.0152","relation":{},"ISSN":["2168-6203"],"issn-type":[{"value":"2168-6203","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,2]]}}}