{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:47:29Z","timestamp":1793062049798,"version":"4.5.0"},"reference-count":50,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Pediatr"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:sec id=\"ab-poi220044-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>The postacute sequelae of SARS-CoV-2 infection (PASC) has emerged as a long-term complication in adults, but current understanding of the clinical presentation of PASC in children is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi220044-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify diagnosed symptoms, diagnosed health conditions, and medications associated with PASC in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi220044-6\">\n                    <jats:title>Design, Setting and Participants<\/jats:title>\n                    <jats:p>This retrospective cohort study used electronic health records from 9 US children\u2019s hospitals for individuals younger than 21 years who underwent antigen or reverse transcriptase\u2013polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 between March 1, 2020, and October 31, 2021, and had at least 1 encounter in the 3 years before testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi220044-7\">\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>SARS-CoV-2 positivity by viral test (antigen or RT-PCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi220044-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Syndromic (symptoms), systemic (conditions), and medication PASC features were identified in the 28 to 179 days following the initial test date. Adjusted hazard ratios (aHRs) were obtained for 151 clinically predicted PASC features by contrasting viral test\u2013positive groups with viral test\u2013negative groups using proportional hazards models, adjusting for site, age, sex, testing location, race and ethnicity, and time period of cohort entrance. The incidence proportion for any syndromic, systemic, or medication PASC feature was estimated in the 2 groups to obtain a burden of PASC estimate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi220044-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 659\u202f286 children in the study sample, 348\u202f091 (52.8%) were male, and the mean (SD) age was 8.1 (5.7) years. A total of 59\u202f893 (9.1%) tested positive by viral test for SARS-CoV-2, and 599\u202f393 (90.9%) tested negative. Most were tested in outpatient testing facility settings (322\u202f813 [50.3%]) or office settings (162\u202f138 [24.6%]). The most common syndromic, systemic, and medication features were loss of taste or smell (aHR, 1.96; 95% CI, 1.16-3.32), myocarditis (aHR, 3.10; 95% CI, 1.94-4.96), and cough and cold preparations (aHR, 1.52; 95% CI, 1.18-1.96), respectively. The incidence of at least 1 systemic, syndromic, or medication feature of PASC was 41.9% (95% CI, 41.4-42.4) among viral test\u2013positive children vs 38.2% (95% CI, 38.1-38.4) among viral test\u2013negative children, with an incidence proportion difference of 3.7% (95% CI, 3.2-4.2). A higher strength of association for PASC was identified in those cared for in the intensive care unit during the acute illness phase, children younger than 5 years, and individuals with complex chronic conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi220044-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>In this large-scale, exploratory study, the burden of pediatric PASC that presented to health systems was low. Myocarditis was the most commonly diagnosed PASC-associated condition. Acute illness severity, young age, and comorbid complex chronic disease increased the risk of PASC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamapediatrics.2022.2800","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T17:27:37Z","timestamp":1661275657000},"page":"1000","source":"Crossref","is-referenced-by-count":154,"title":["Clinical Features and Burden of Postacute Sequelae of SARS-CoV-2 Infection in Children and Adolescents"],"prefix":"10.1001","volume":"176","author":[{"given":"Suchitra","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Colorado School of Medicine and Children\u2019s Hospital Colorado, Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Infectious Diseases), Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanieh","family":"Razzaghi","sequence":"additional","affiliation":[{"name":"Applied Clinical Research Center, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Lorman","sequence":"additional","affiliation":[{"name":"Applied Clinical Research Center, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuncion","family":"Mejias","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Nationwide Children\u2019s Hospital and The Ohio State University, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan M.","family":"Pajor","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Cincinnati Children\u2019s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Thacker","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Nemours Children\u2019s Health, Wilmington, Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Webb","sequence":"additional","affiliation":[{"name":"Applied Clinical Research Center, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Dickinson","sequence":"additional","affiliation":[{"name":"Applied Clinical Research Center, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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