{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:09:58Z","timestamp":1786975798933,"version":"build-2736575974"},"reference-count":16,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Pediatr"],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"\n Importance<\/jats:title>\n Early onset of myopia increases the risk of high myopia, which can lead to irreversible retinal damage and even loss of central vision.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate the efficacy and safety of naked-eye 3-dimensional vision training (NVT) in preventing the progression of myopia in children.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This randomized clinical trial was conducted in 3 hospitals from May 25, 2022, to February 24, 2023. Participants were children (aged 6-18 years) who had a diagnosis of myopia with a spherical equivalent refraction of \u22120.75 to \u22126.00 diopters (D).<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n Children in the intervention group received 20 minutes of NVT treatment every day, whereas children in the control group lived as usual without vision training.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome and Measure<\/jats:title>\n The primary outcome was the change in axial length at 6 months. Spherical equivalent refraction (SER) was included as a secondary outcome.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 263 participants, 125 (47.5%) were male and 138 (52.5%) were female; the mean (SD) age was 10.3 (1.9) years (range, 6.1-15.6 years). A total of 227 patients (86.3%) completed the 6-month follow-up, including 102 in the intervention group and 125 in the control group. In the intervention group, the changes in axial length and SER at 6 months were 0.18 mm (95% CI, 0.16 to 0.20 mm) and \u22120.25 D (95% CI, \u22120.31 to \u22120.19 D), respectively. In the control group, the changes in axial length and SER at 6 months were 0.23 mm (95% CI, 0.21 to 0.25 mm) and \u22120.35 D (95% CI, \u22120.41 to \u22120.30 D), respectively. The differences in AL and SER between the 2 groups were significant (AL difference: \u22120.06 mm; 95% CI, \u22120.09 to \u22120.03;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001; SER difference: 0.10 D; 95% CI, 0.02 to 0.19;\n P<\/jats:italic>\n \u2009=\u2009.02). No study-related adverse reactions were reported during follow-up.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n NVT is a safe and promising means to control myopia progression in children with good adherence.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT05468775<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamapediatrics.2024.0578","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T11:01:12Z","timestamp":1712574072000},"page":"533","source":"Crossref","is-referenced-by-count":14,"title":["Naked-Eye 3-Dimensional Vision Training for Myopia Control"],"prefix":"10.1001","volume":"178","author":[{"given":"Rui","family":"Xie","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Yu","sequence":"additional","affiliation":[{"name":"Foshan Women and Children\u2018s Hospital, Foshan, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shenzhen People\u2018s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, 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College, Jinan University), Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Wang","sequence":"additional","affiliation":[{"name":"Foshan Women and Children\u2018s Hospital, Foshan, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingting","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehong","family":"Zhuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen 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