{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:13:59Z","timestamp":1790615639016,"version":"4.1.0"},"reference-count":23,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Pediatr"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"Importance<\/jats:title>Infants with neonatal opioid withdrawal syndrome (NOWS) cared for with the Eat, Sleep, Console (ESC) care approach receive less pharmacologic treatment and have shorter hospital stays compared to usual care with the Finnegan Neonatal Abstinence Scoring Tool, but the effects of these approaches on feeding and weight are unknown.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate feeding practices and weight trajectories in infants cared for with ESC vs usual care.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>ESC-NOW is a cluster randomized trial of infants with NOWS born at 36 weeks\u2019 gestation or later at 26 US hospitals from September 2020 to March 2022. Each site transitioned from usual care to ESC (the study intervention) at a randomized time. Feeding was per site practice and not specified by the intervention. Feeding and weight outcomes were assessed at hospital discharge.<\/jats:p><\/jats:sec>Intervention<\/jats:title>ESC vs usual care.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Outcomes include prospectively identified secondary end points related to feeding and weight. z<\/jats:italic> Scores were used for growth to account for corrected gestational age at the time of measurement. All analyses were intention to treat and adjusted for study design. Maternal\/infant characteristics were included in adjusted models.<\/jats:p><\/jats:sec>Results<\/jats:title>The analyses included 1305 infants (702 in usual care and 603 in ESC; mean [SD] gestational age, 38.6 [1.3] weeks; 655 [50.2%] male and 650 [49.8%] female). Baseline demographic characteristics were similar between groups. The proportion of breastfed infants was higher in the ESC group (52.7% vs 41.7%; absolute difference, 11%; 95% CI, 1.0-20.9). A higher proportion of infants cared for with ESC received exclusive breast milk (15.1% vs 6.7%; absolute difference, 8.4%; 95% CI, 0.9-5.8) or any breast milk (38.8% vs 27.4%; absolute difference, 11.4%; 95% CI, 0.2-23.1) and were directly breastfeeding at discharge (35.2% vs 19.5%; absolute difference, 15.7%; 95% CI, 4.1-27.3). There was no difference in proportion of infants with weight loss greater than 10% or maximum percentage weight loss, although infants cared for with ESC had a lower weight z<\/jats:italic> score on day of life 3 (\u22121.08 vs \u22121.01; absolute difference, 0.07; 95% CI, 0.02-0.12). When pharmacologic treatment was added into the model, no breastfeeding outcomes were statistically significant.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this study, infants cared for with ESC were more likely to initiate and continue breastfeeding and had no difference in percentage weight loss. The improvement in breastfeeding with ESC may be driven by reduction in pharmacologic treatment and provision of effective nonpharmacologic care.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>ClinicalTrials.gov Identifier: NCT04057820<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jamapediatrics.2024.2578","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T15:01:10Z","timestamp":1723474870000},"page":"976","source":"Crossref","is-referenced-by-count":9,"title":["Infant Feeding and Weight Trajectories in the Eat, Sleep, Console Trial"],"prefix":"10.1001","volume":"178","author":[{"given":"Stephanie L.","family":"Merhar","sequence":"first","affiliation":[{"name":"Perinatal Institute, Division of Neonatology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuopei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Devlin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Louisville, Louisville, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songthip T.","family":"Ounpraseuth","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan E.","family":"Simon","sequence":"additional","affiliation":[{"name":"Institutional Development Awards States Pediatric Clinical Trials Network, Environmental Influences on Child Health Outcomes Program, National Institutes of Health, Rockville, Maryland"},{"name":"Now with the National Center for Health Statistics, US Centers for Disease Control and Prevention, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Brian","family":"Smith","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele C.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhik","family":"Das","sequence":"additional","affiliation":[{"name":"Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary 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