{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:29:58Z","timestamp":1790418598859,"version":"4.1.0"},"reference-count":51,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Pediatr"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"Importance<\/jats:title>Programs that provide home visiting in early life have been proposed as a way to reduce early childhood adversity and improve child health outcomes. More evidence is needed to understand these programs\u2019 impact when delivered at scale.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate how receiving home visits through the Nurse-Family Partnership (NFP), a program designed to support young and low-income families, impacted children\u2019s utilization and health outcomes in the 2 years after birth.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>The NFP is a home visiting program designed with the aim of reducing the incidence of adverse health outcomes in early childhood. In this study, we used data from a randomized clinical trial that enrolled 5670 Medicaid-eligible pregnant people in South Carolina who were randomly assigned at a 2:1 ratio to the NFP treatment (n\u2009=\u20093806) or usual care (n\u2009=\u20091864) between 2016 and 2020. The trial was conducted in 9 NFP-implementing authorities. Participants were eligible if they were fewer than 28 weeks pregnant with their first child, aged 15 years or older, and income eligible for Medicaid (income &amp;lt;200% of the federal poverty level). Data analysis was performed from June 2023 to July 2024.<\/jats:p><\/jats:sec>Intervention<\/jats:title>The treatment group was offered NFP home visits during pregnancy and 2 years postpartum, while the control group received usual care.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcome was a composite measure that included child mortality and claims related to major injury or concern for abuse or neglect within the first 2 years of life. Secondary outcomes included emergency department utilization and preventive health care measures, such as well-child visits and their components, including screenings for cognitive development, blood lead levels, fluoride varnish application, and dental health. We used an intent-to-treat approach with a linear regression model to estimate the treatment effect of NFP on early childhood outcomes by comparing participants assigned to the control and treatment group, regardless of whether they used NFP services.<\/jats:p><\/jats:sec>Results<\/jats:title>Among enrolled participants, 4932 individuals were tracked to a live birth (3295 in the intervention group and 1637 in the control group) and were analyzed for child health and utilization outcomes once their child turned 2 years old. Mean (SD) participant age was 22.5 (4.7) years. The incidence of the composite adverse outcome was 27.3% and 26.8% in the intervention and control groups, respectively (adjusted between-group difference, 0.4 percentage points; 95% CI, \u22122.3 to 3.0), with no statistically significant differences between elements of the composite primary outcome. Among participants assigned to receive NFP, their children were less likely to use the emergency department by 2.9 percentage points (95% CI, \u22125.5 to \u22120.3), a 4% reduction relative to the rate of 72.8% in the control group. Once we adjusted for multiple hypothesis testing, this outcome was no longer statistically significant. Assignment to NFP did not significantly impact the likelihood of receiving the guideline number of well-child visits or preventive services.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this randomized clinical trial, assignment to intensive nurse home visiting services did not reduce the likelihood of adverse outcomes in early childhood measured through administrative data. More evidence is needed to understand whether delivering intensive home visiting services at scale to a Medicaid population influences other child outcomes, including longer-term developmental outcomes.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>ClinicalTrials.gov Identifier: NCT03360539<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jamapediatrics.2025.1600","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T11:31:18Z","timestamp":1750073478000},"page":"857","source":"Crossref","is-referenced-by-count":10,"title":["Intensive Nurse Home Visiting and Early Childhood Outcomes"],"prefix":"10.1001","volume":"179","author":[{"given":"Katarina","family":"Swanson","sequence":"first","affiliation":[{"name":"Harvard PhD Program in Health Policy, Harvard University, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Ayers","sequence":"additional","affiliation":[{"name":"Berkeley PhD Program in Public Policy, University of California, Berkeley"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dea","family":"Oviedo","sequence":"additional","affiliation":[{"name":"Department of Global Health and Population, Harvard T. 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