{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:55:28Z","timestamp":1777953328904,"version":"3.51.4"},"reference-count":24,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Pediatr"],"published-print":{"date-parts":[[2026,5,1]]},"DOI":"10.1001\/jamapediatrics.2026.0182","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:30:29Z","timestamp":1773675029000},"page":"481","source":"Crossref","is-referenced-by-count":0,"title":["Valved Holding Chambers for Acute Wheezing in Young Children"],"prefix":"10.1001","volume":"180","author":[{"given":"Donald H.","family":"Arnold","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Zorc","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10","reference":[{"issue":"2","key":"ped260002r2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0196-0644(98)70132-5","article-title":"Pediatric risk of admission (PRISA): a measure of severity of illness for assessing the risk of hospitalization from the emergency department.","volume":"32","author":"Chamberlain","year":"1998","journal-title":"Ann Emerg Med"},{"issue":"3","key":"ped260002r3","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1542\/peds.2014-1278","article-title":"Variation in emergency department admission rates in US children\u2019s hospitals.","volume":"134","author":"Bourgeois","year":"2014","journal-title":"Pediatrics"},{"issue":"3","key":"ped260002r4","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1001\/archpedi.154.3.287","article-title":"Prevalence, impact, and trends in childhood disability due to asthma.","volume":"154","author":"Newacheck","year":"2000","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"1","key":"ped260002r5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jaci.2010.10.020","article-title":"Costs of asthma in the US: 2002-2007.","volume":"127","author":"Barnett","year":"2011","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"ped260002r6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2015-2354","article-title":"Changing trends in asthma prevalence among children.","volume":"137","author":"Akinbami","year":"2016","journal-title":"Pediatrics"},{"issue":"1","key":"ped260002r7","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1542\/peds.114.1.116","article-title":"Community organization to reduce the need for acute care for asthma among African American children in low-income neighborhoods: the Neighborhood Asthma Coalition.","volume":"114","author":"Fisher","year":"2004","journal-title":"Pediatrics"},{"issue":"5","key":"ped260002r8","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1542\/peds.109.5.857","article-title":"Racial\/ethnic variation in asthma status and management practices among children in managed Medicaid.","volume":"109","author":"Lieu","year":"2002","journal-title":"Pediatrics"},{"issue":"6","key":"ped260002r9","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1001\/jama.1995.03530060043031","article-title":"Use of health services by African American children with asthma on Medicaid.","volume":"274","author":"Lozano","year":"1995","journal-title":"JAMA"},{"issue":"1","key":"ped260002r10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1001\/archpedi.157.1.81","article-title":"Asthma medication use and disease burden in children in a primary care population.","volume":"157","author":"Lozano","year":"2003","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"5","key":"ped260002r11","doi-asserted-by":"publisher","first-page":"149","DOI":"10.15585\/mmwr.mm6705e1","article-title":"Vital signs: asthma in children\u2014US, 2001-2016.","volume":"67","author":"Zahran","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"2","key":"ped260002r12","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1001\/jama.2024.22700","article-title":"Inhaled reliever therapies for asthma: a systematic review and meta-analysis.","volume":"333","author":"Rayner","year":"2025","journal-title":"JAMA"},{"key":"ped260002r13","doi-asserted-by":"publisher","first-page":"S78","DOI":"10.1089\/jam.2007.0572","article-title":"Face masks and aerosol delivery in vivo.","volume":"20","author":"Erzinger","year":"2007","journal-title":"J Aerosol Med"},{"issue":"9","key":"ped260002r14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000052.pub3","article-title":"Holding chambers (spacers) vs nebulizers for \u00df-agonist treatment of acute asthma.","volume":"2013","author":"Cates","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"ped260002r15","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1080\/02770903.2018.1514629","article-title":"Improving efficiency of pediatric emergency asthma treatment by using metered dose inhaler.","volume":"56","author":"Abaya","year":"2019","journal-title":"J Asthma"},{"issue":"2","key":"ped260002r16","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.jaip.2023.11.013","article-title":"Salbutamol delivery in small children: effect of valved holding chamber and breathing patterns.","volume":"12","author":"Ojanper\u00e4","year":"2024","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"1","key":"ped260002r17","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/S0022-3476(99)70323-9","article-title":"Inhalation therapy in asthma: nebulizer or pressurized metered-dose inhaler with holding chamber\u2014in vivo comparison of lung deposition in children.","volume":"135","author":"Wildhaber","year":"1999","journal-title":"J Pediatr"},{"issue":"1","key":"ped260002r18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0022-3476(99)70317-3","article-title":"Asthma therapy with aerosols: are nebulizers obsolete: a continuing controversy.","volume":"135","author":"Newhouse","year":"1999","journal-title":"J Pediatr"},{"key":"ped260002r20","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2025.6479","article-title":"Valved holding chambers in young children with acute wheezing: a randomized clinical trial.","author":"Csonka","journal-title":"JAMA Pediatr"},{"issue":"9","key":"ped260002r21","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1002\/ppul.24425","article-title":"In vitro drug delivery performance of 5 valved holding chambers with and without face masks.","volume":"54","author":"Csonka","year":"2019","journal-title":"Pediatr Pulmonol"},{"issue":"5","key":"ped260002r22","doi-asserted-by":"publisher","first-page":"e1474","DOI":"10.1542\/peds.2014-2742","article-title":"Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis.","volume":"134","author":"Ralston","year":"2014","journal-title":"Pediatrics"},{"key":"ped260002r1","unstructured":"Agency for Healthcare Research and Quality. Healthcare Cost and Utilization Project (HCUPnet). Accessed January 10, 2026. https:\/\/datatools.ahrq.gov\/hcupnet\/"},{"key":"ped260002r19","unstructured":"Global Initiative for Asthma. Global strategy for asthma management and prevention. Accessed January 10, 2026. https:\/\/ginasthma.org\/2025-gina-strategy-report\/"},{"key":"ped260002r23","unstructured":"US Food and Drug Administration. Device approvals and clearances. Accessed January 10, 2026. https:\/\/www.fda.gov\/medical-devices\/products-and-medical-procedures\/device-approvals-and-clearances"},{"key":"ped260002r24","unstructured":"Department of Health & Human Services. OptiChamber Diamond-Valved Holding Chamber 510(k) summary. Accessed January 10, 2026. https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf11\/k110293.pdf"}],"container-title":["JAMA Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/articlepdf\/2845863\/jamapediatrics_arnold_2026_ed_260002_1777584380.52336.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:00:52Z","timestamp":1777906852000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/fullarticle\/2845863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapediatrics.2026.0182","relation":{},"ISSN":["2168-6203"],"issn-type":[{"value":"2168-6203","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,1]]}}}