{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:35:21Z","timestamp":1784000121789,"version":"3.55.0"},"reference-count":54,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Pediatr"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec id=\"ab-poi260009-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Although pediatric pain can impede healthy development throughout adulthood, the prevalence of chronic pain among US children with developmental disabilities remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi260009-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate parent-reported chronic pain prevalence and the association between developmental disabilities and chronic pain in US children and adolescents (hereinafter, children).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi260009-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This national survey study included 263\u202f168 children aged 3 to 17 years who participated in the 2016-2023 National Survey of Children\u2019s Health (NSCH). Data were analyzed from June 2025 to August 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi260009-7\">\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>Reporting any of the 10 developmental disabilities included in the NSCH: seizure, cerebral palsy, autism, attention-deficit\/hyperactivity disorder, vision, hearing, and\/or speech delay, intellectual and\/or learning disability, and developmental delay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi260009-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>The weighted prevalence of parent-reported chronic pain in children with or without any of these 10 disabilities was calculated across the study period and by year. Logistic regression models were applied to examine the association between various categories of developmental disabilities and pain among US children as well as potential health disparities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi260009-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included a weighted sample of 224\u202f467\u202f664 children based on an analytic sample of 263\u202f168 children; of them, 135\u202f848 (51.1%) were male with a mean (SD) age of 10.2 (4.5) years. Approximately 18.7% of children reported having at least 1 disability. The weighted prevalence of parent-reported chronic pain was higher in children with at least 1 developmental disability compared to peers without a disability (13.2% vs 5.5%) over the study period. Adjusted analyses revealed significant associations between any of the disabilities and parent-reported chronic pain, with an odds ratio of 2.31 (95% CI, 2.14-2.49). Similar positive associations were also observed for all disability categories, particularly seizure and cerebral palsy. Moreover, higher odds of parent-reported chronic pain were associated with lower levels of parental education and family income, or more adverse childhood experiences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-poi260009-10\">\n                    <jats:title>Conclusion and Relevance<\/jats:title>\n                    <jats:p>The findings in this study indicate that children with diverse developmental disabilities were more likely to have parent-reported chronic pain, and this likelihood was associated with several socioeconomic factors. These findings provide important insights into targeted screening and interventions for pain in pediatric populations with developmental disabilities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamapediatrics.2026.0512","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:30:30Z","timestamp":1774884630000},"page":"679","source":"Crossref","is-referenced-by-count":3,"title":["Parent-Reported Chronic Pain in Children With and Without Developmental Disabilities"],"prefix":"10.1001","volume":"180","author":[{"given":"Wenming","family":"Shi","sequence":"first","affiliation":[{"name":"Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Kan","sequence":"additional","affiliation":[{"name":"Center for Global Digital Health Innovation, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongshuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Starkids Children\u2019s Hospital, Shanghai, New Hong Qiao Campus for Children\u2019s Hospital of Fudan University, Shanghai, China"},{"name":"School of Public Health, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"9995","key":"poi260009r1","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.","volume":"386","author":"Vos","year":"2015","journal-title":"Lancet"},{"issue":"2","key":"poi260009r2","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/ejp.1306","article-title":"Prevalence of self-reported chronic pain among adolescents: evidence from 42 countries and regions.","volume":"23","author":"Gobina","year":"2019","journal-title":"Eur J Pain"},{"issue":"5","key":"poi260009r3","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1001\/jamapediatrics.2020.5680","article-title":"Association of headache with school functioning among children and adolescents in the United States.","volume":"175","author":"Turner","year":"2021","journal-title":"JAMA Pediatr"},{"issue":"5","key":"poi260009r4","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1097\/j.pain.0000000000000137","article-title":"Health care expenditures associated with pediatric pain-related conditions in the United States.","volume":"156","author":"Groenewald","year":"2015","journal-title":"Pain"},{"issue":"6","key":"poi260009r5","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00787-012-0261-1","article-title":"Psychosocial determinants of headache, abdominal pain, and sleep problems in a community sample of Finnish adolescents.","volume":"21","author":"Luntamo","year":"2012","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"3","key":"poi260009r6","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1001\/jamapsychiatry.2021.3815","article-title":"Neurodevelopmental disorders among publicly or privately insured children in the United States.","volume":"79","author":"Straub","year":"2022","journal-title":"JAMA Psychiatry"},{"issue":"4","key":"poi260009r7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-0811","article-title":"Prevalence and trends of developmental disabilities among children in the United States: 2009-2017.","volume":"144","author":"Zablotsky","year":"2019","journal-title":"Pediatrics"},{"issue":"1","key":"poi260009r9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/PEP.0b013e3181ccbabb","article-title":"The prevalence, distribution, and effect of pain among adolescents with cerebral palsy.","volume":"22","author":"Doralp","year":"2010","journal-title":"Pediatr Phys Ther"},{"issue":"3","key":"poi260009r10","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/j.1651-2227.2009.01626.x","article-title":"Pain in children with cerebral palsy: a cross-sectional multicentre European study.","volume":"99","author":"Parkinson","year":"2010","journal-title":"Acta Paediatr"},{"issue":"5","key":"poi260009r11","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/AJP.0000000000000554","article-title":"Pain in children with developmental disabilities: development and preliminary effectiveness of a pain training workshop for respite workers.","volume":"34","author":"Genik","year":"2018","journal-title":"Clin J Pain"},{"issue":"2","key":"poi260009r12","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1155\/2009\/642352","article-title":"Assessing pain in children with intellectual disabilities.","volume":"14","author":"Breau","year":"2009","journal-title":"Pain Res Manag"},{"key":"poi260009r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2021.110717","article-title":"Neuroinflammation as a possible link between attention-deficit\/hyperactivity disorder (ADHD) and pain.","volume":"157","author":"Kerekes","year":"2021","journal-title":"Med Hypotheses"},{"key":"poi260009r14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12991-016-0095-1","article-title":"Sensory cognitive abnormalities of pain in autism spectrum disorder: a case-control study.","volume":"15","author":"Yasuda","year":"2016","journal-title":"Ann Gen Psychiatry"},{"issue":"11","key":"poi260009r15","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/j.rasd.2014.07.018","article-title":"One-year course and predictors of abdominal pain in children with autism spectrum disorders: the role of anxiety and sensory over-responsivity.","volume":"8","author":"Mazurek","year":"2014","journal-title":"Res Autism Spectr Disord"},{"key":"poi260009r16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.ridd.2017.01.003","article-title":"Daily living pain assessment in children with autism: exploratory study.","volume":"62","author":"Dubois","year":"2017","journal-title":"Res Dev Disabil"},{"key":"poi260009r17","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.ridd.2014.12.020","article-title":"Acute behavioral crises in psychiatric inpatients with autism spectrum disorder (ASD): recognition of concomitant medical or non-ASD psychiatric conditions predicts enhanced improvement.","volume":"38","author":"Guinchat","year":"2015","journal-title":"Res Dev Disabil"},{"key":"poi260009r18","doi-asserted-by":"publisher","first-page":"3867","DOI":"10.2147\/JPR.S472414","article-title":"Frequent pain is common among 10-11-year-old children with symptoms of attention deficit hyperactivity disorder.","volume":"17","author":"Berggren","year":"2024","journal-title":"J Pain Res"},{"issue":"11","key":"poi260009r19","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1111\/dmcn.14615","article-title":"Pain in children with dyskinetic and mixed dyskinetic\/spastic cerebral palsy.","volume":"62","author":"McKinnon","year":"2020","journal-title":"Dev Med Child Neurol"},{"issue":"5","key":"poi260009r20","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1007\/s00787-023-02249-x","article-title":"Prevalence of chronic and multisite pain in adolescents and young adults with ADHD: a comparative study between clinical and general population samples (the HUNT study).","volume":"33","author":"Mundal","year":"2024","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"1","key":"poi260009r21","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1186\/s12887-021-02928-1","article-title":"Chronic pain among children with cerebral palsy attending a Ugandan tertiary hospital: a cross-sectional study.","volume":"21","author":"Bambi","year":"2021","journal-title":"BMC Pediatr"},{"issue":"2","key":"poi260009r24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.amepre.2024.03.010","article-title":"Sexual orientation\/gender identity discrimination and chronic pain in children: a national study.","volume":"67","author":"Weiss","year":"2024","journal-title":"Am J Prev Med"},{"issue":"1","key":"poi260009r25","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/j.pain.0000000000003020","article-title":"Comparing the prevalence of chronic pain in school-aged children in the United States from 2019 to 2020: a nationally representative study examining differences associated with the COVID-19 pandemic.","volume":"165","author":"Kapos","year":"2024","journal-title":"Pain"},{"issue":"6","key":"poi260009r26","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7728","article-title":"Estimated prevalence of asthma in US children with developmental disabilities.","volume":"3","author":"Xie","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"12","key":"poi260009r27","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1001\/jamapediatrics.2019.3826","article-title":"National prevalence of pain among children and adolescents with autism spectrum disorders.","volume":"173","author":"Whitney","year":"2019","journal-title":"JAMA Pediatr"},{"key":"poi260009r28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2025.105432","article-title":"Chronic pain among Asian American children and associations with racial and ethnic discrimination: a nationally representative study.","volume":"33","author":"Ma","year":"2025","journal-title":"J Pain"},{"issue":"5","key":"poi260009r29","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000839","article-title":"Adverse childhood experiences and chronic pain among children and adolescents in the United States.","volume":"5","author":"Groenewald","year":"2020","journal-title":"Pain Rep"},{"issue":"7","key":"poi260009r30","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1001\/jamainternmed.2025.1260","article-title":"Trends and disparities in maternal self-reported mental and physical health.","volume":"185","author":"Daw","year":"2025","journal-title":"JAMA Intern Med"},{"issue":"8","key":"poi260009r31","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1001\/jamasurg.2025.1809","article-title":"Food insecurity in US surgical patients: findings from the national health interview survey.","volume":"160","author":"Jones","year":"2025","journal-title":"JAMA Surg"},{"issue":"3","key":"poi260009r32","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/j.pain.0000000000003066","article-title":"A systematic review of self and observer assessment of pain and related functioning in youth with brain-based developmental disabilities.","volume":"165","author":"Noyek","year":"2024","journal-title":"Pain"},{"issue":"2","key":"poi260009r33","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.apmr.2019.08.475","article-title":"Acute and chronic pain in children and adolescents with cerebral palsy: prevalence, interference, and management.","volume":"101","author":"Ostojic","year":"2020","journal-title":"Arch Phys Med Rehabil"},{"issue":"6","key":"poi260009r34","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1016\/j.ridd.2011.05.023","article-title":"Pain disrupts sleep in children and youth with intellectual and developmental disabilities.","volume":"32","author":"Breau","year":"2011","journal-title":"Res Dev Disabil"},{"key":"poi260009r35","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.1542\/peds.2016-2828H","article-title":"Neurodevelopment: the impact of nutrition and inflammation during early to middle childhood in low-resource settings.","volume":"139","author":"John","year":"2017","journal-title":"Pediatrics"},{"issue":"1","key":"poi260009r36","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1037\/0033-2909.134.1.31","article-title":"Executive function in preschoolers: a review using an integrative framework.","volume":"134","author":"Garon","year":"2008","journal-title":"Psychol Bull"},{"issue":"1","key":"poi260009r37","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1186\/s12887-024-04951-4","article-title":"Early childhood risk factors for later onset of pediatric chronic pain: a multi-method longitudinal study.","volume":"24","author":"Pavlova","year":"2024","journal-title":"BMC Pediatr"},{"issue":"9","key":"poi260009r38","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1111\/dmcn.13930","article-title":"Pathophysiology of chronic pain in cerebral palsy: implications for pharmacological treatment and research.","volume":"60","author":"Blackman","year":"2018","journal-title":"Dev Med Child Neurol"},{"issue":"9969","key":"poi260009r39","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S0140-6736(14)61229-0","article-title":"Self-reported quality of life of adolescents with cerebral palsy: a cross-sectional and longitudinal analysis.","volume":"385","author":"Colver","year":"2015","journal-title":"Lancet"},{"issue":"21","key":"poi260009r40","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.3109\/09638288.2014.882417","article-title":"Child engagement in daily life: a measure of participation for young children with cerebral palsy.","volume":"36","author":"Chiarello","year":"2014","journal-title":"Disabil Rehabil"},{"issue":"1","key":"poi260009r41","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1037\/hea0001464","article-title":"Assessing the impact of social support and social isolation on pain intensity and pain interference among Native Americans with chronic pain.","volume":"45","author":"Brown","year":"2026","journal-title":"Health Psychol"},{"issue":"12","key":"poi260009r42","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s11920-013-0421-0","article-title":"Pain and depression: an integrative review of neurobiological and psychological factors.","volume":"15","author":"Goesling","year":"2013","journal-title":"Curr Psychiatry Rep"},{"issue":"1-2","key":"poi260009r43","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jpain.2019.06.007","article-title":"Sociodemographic and environmental factors are associated with adolescents\u2019 pain and longitudinal health outcomes.","volume":"21","author":"Tran","year":"2020","journal-title":"J Pain"},{"issue":"5","key":"poi260009r44","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jpain.2008.12.001","article-title":"Sex, gender, and pain: a review of recent clinical and experimental findings.","volume":"10","author":"Fillingim","year":"2009","journal-title":"J Pain"},{"issue":"4","key":"poi260009r45","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/j.pain.0000000000000803","article-title":"Sex differences in the efficacy of psychological therapies for the management of chronic and recurrent pain in children and adolescents: a systematic review and meta-analysis.","volume":"258","author":"Boerner","year":"2017","journal-title":"Pain"},{"issue":"3","key":"poi260009r46","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.pain.2006.03.004","article-title":"Sex differences in adolescent chronic pain and pain-related coping.","volume":"123","author":"Keogh","year":"2006","journal-title":"Pain"},{"issue":"2","key":"poi260009r47","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jpain.2016.10.009","article-title":"The effect of pain catastrophizing on outcomes: a developmental perspective across children, adolescents, and young adults with chronic pain.","volume":"18","author":"Feinstein","year":"2017","journal-title":"J Pain"},{"issue":"1-2","key":"poi260009r48","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.pain.2006.08.027","article-title":"Children with chronic pain: impact of sex and age on long-term outcomes.","volume":"128","author":"Martin","year":"2007","journal-title":"Pain"},{"issue":"12","key":"poi260009r49","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1016\/j.pain.2011.07.016","article-title":"The epidemiology of chronic pain in children and adolescents revisited: a systematic review.","volume":"152","author":"King","year":"2011","journal-title":"Pain"},{"issue":"11","key":"poi260009r50","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1097\/AJP.0000000000001148","article-title":"Risk factors for the development of multisite pain in children.","volume":"39","author":"Kaplan","year":"2023","journal-title":"Clin J Pain"},{"issue":"3","key":"poi260009r51","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1093\/rheumatology\/keaa758","article-title":"Socioeconomic status and occurrence of chronic pain: a meta-analysis.","volume":"60","author":"Prego-Dom\u00ednguez","year":"2021","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"poi260009r52","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1097\/AJP.0000000000001199","article-title":"Cost-of-illness and economic evaluation of interventions in children and adolescents with chronic pain: a systematic review.","volume":"40","author":"Kitschen","year":"2024","journal-title":"Clin J Pain"},{"issue":"7","key":"poi260009r53","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.jpain.2023.02.001","article-title":"Positive childhood experiences and chronic pain among children and adolescents in the United States.","volume":"24","author":"Pugh","year":"2023","journal-title":"J Pain"},{"issue":"4","key":"poi260009r54","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/children3040035","article-title":"Neighborhood characteristics: influences on pain and physical function in youth at risk for chronic pain.","volume":"3","author":"Schild","year":"2016","journal-title":"Children (Basel)"},{"key":"poi260009r8","unstructured":"Institute Of Medicine (US) Committee on Nervous System Disorders in Developing Countries. Neurological, psychiatric, and developmental disorders: meeting the challenge in the developing world. Accessed November 10, 2025.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK223473\/."},{"key":"poi260009r22","unstructured":"US Census Bureau. National survey of children\u2019s health, 2025. https:\/\/www.census.gov\/programs-surveys\/nsch.html"},{"key":"poi260009r23","unstructured":"Data Resource Center for Child & Adolescent Health. The national survey of children's health. Accessed February 23, 2026. https:\/\/www.childhealthdata.org\/learn-about-the-nsch"}],"container-title":["JAMA Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/articlepdf\/2846793\/jamapediatrics_shi_2026_oi_260009_1783623078.11648.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:00:33Z","timestamp":1783954833000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/fullarticle\/2846793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapediatrics.2026.0512","relation":{},"ISSN":["2168-6203"],"issn-type":[{"value":"2168-6203","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,1]]}}}