{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:09:28Z","timestamp":1788318568531,"version":"build-2803163510"},"reference-count":36,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2019,11,1]]},"DOI":"10.1001\/jamapsychiatry.2019.1694","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T11:39:19Z","timestamp":1563968359000},"page":"1198","source":"Crossref","is-referenced-by-count":56,"title":["Association of Methionine to Homocysteine Status With Brain Magnetic Resonance Imaging Measures and Risk of Dementia"],"prefix":"10.1001","volume":"76","author":[{"given":"Babak","family":"Hooshmand","sequence":"first","affiliation":[{"name":"Aging Research Center, Karolinska Institute, Stockholm, Sweden"},{"name":"Department of Neurology, Ulm University Hospital, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Refsum","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford, United Kingdom"},{"name":"Institute of Nutrition, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. David","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goria","family":"Kalpouzos","sequence":"additional","affiliation":[{"name":"Aging Research Center, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mangialasche","sequence":"additional","affiliation":[{"name":"Aging Research Center, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A. F.","family":"von Arnim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University Hospital, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingemar","family":"K\u00e5reholt","sequence":"additional","affiliation":[{"name":"Aging Research Center, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Kivipelto","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden"},{"name":"Theme Aging, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Stockholms Sjukhem, Research & Development Unit, Stockholm, Sweden"},{"name":"Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, United Kingdom"},{"name":"Department of Neurology, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fratiglioni","sequence":"additional","affiliation":[{"name":"Aging Research Center, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"Pt 9","key":"yoi190040r1","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1093\/brain\/awt206","article-title":"Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study.","volume":"136","author":"Hooshmand","year":"2013","journal-title":"Brain"},{"issue":"6","key":"yoi190040r2","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1373\/clinchem.2006.085241","article-title":"Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid.","volume":"53","author":"Obeid","year":"2007","journal-title":"Clin Chem"},{"issue":"1","key":"yoi190040r3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.psc.2012.12.001","article-title":"Folate, vitamin B12, and S-adenosylmethionine.","volume":"36","author":"Bottiglieri","year":"2013","journal-title":"Psychiatr Clin North Am"},{"issue":"5","key":"yoi190040r4","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.neuron.2014.01.037","article-title":"S-adenosylmethionine levels regulate the schwann cell DNA methylome.","volume":"81","author":"Varela-Rey","year":"2014","journal-title":"Neuron"},{"key":"yoi190040r5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/bs.afnr.2017.11.005","article-title":"Vitamin B12.","volume":"83","author":"Smith","year":"2018","journal-title":"Adv Food Nutr Res"},{"issue":"1","key":"yoi190040r6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","article-title":"Facts and recommendations about total homocysteine determinations: an expert opinion.","volume":"50","author":"Refsum","year":"2004","journal-title":"Clin Chem"},{"key":"yoi190040r7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1146\/annurev-nutr-071715-050947","article-title":"Homocysteine, B vitamins, and cognitive impairment.","volume":"36","author":"Smith","year":"2016","journal-title":"Annu Rev Nutr"},{"issue":"2","key":"yoi190040r8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3233\/JAD-171042","article-title":"Homocysteine and dementia: an international consensus statement.","volume":"62","author":"Smith","year":"2018","journal-title":"J Alzheimers Dis"},{"issue":"11","key":"yoi190040r9","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.","volume":"55","author":"Clarke","year":"1998","journal-title":"Arch Neurol"},{"issue":"1","key":"yoi190040r10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13195-017-0270-x","article-title":"One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond.","volume":"9","author":"Dayon","year":"2017","journal-title":"Alzheimers Res Ther"},{"issue":"6","key":"yoi190040r11","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1159\/000309657","article-title":"S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer\u2019s disease.","volume":"7","author":"Linnebank","year":"2010","journal-title":"Neurodegener Dis"},{"issue":"4","key":"yoi190040r12","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3233\/JAD-2009-1187","article-title":"Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer\u2019s disease.","volume":"18","author":"Popp","year":"2009","journal-title":"J Alzheimers Dis"},{"issue":"11","key":"yoi190040r13","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1212\/01.WNL.0000129504.60409.88","article-title":"Plasma homocysteine levels and risk of Alzheimer disease.","volume":"62","author":"Luchsinger","year":"2004","journal-title":"Neurology"},{"issue":"3","key":"yoi190040r14","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/S0006-3223(02)01451-8","article-title":"Alzheimer\u2019s disease and total plasma aminothiols.","volume":"53","author":"McCaddon","year":"2003","journal-title":"Biol Psychiatry"},{"issue":"6","key":"yoi190040r15","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1001\/jamapsychiatry.2016.0274","article-title":"Association of vitamin B12, folate, and sulfur amino acids with brain magnetic resonance imaging measures in older adults: a longitudinal population-based study.","volume":"73","author":"Hooshmand","year":"2016","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"yoi190040r16","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1037\/a0030829","article-title":"Genetic effects on old-age cognitive functioning: a population-based study.","volume":"28","author":"Laukka","year":"2013","journal-title":"Psychol Aging"},{"issue":"2","key":"yoi190040r17","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/BF03324546","article-title":"A longitudinal study integrating population, care and social services data: the Swedish National Study on Aging and Care (SNAC).","volume":"16","author":"Lagergren","year":"2004","journal-title":"Aging Clin Exp Res"},{"key":"yoi190040r19","author":"Fratiglioni","year":"1992"},{"issue":"11","key":"yoi190040r20","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1212\/01.wnl.0000325581.26991.f2","article-title":"Vitamin B12 status and rate of brain volume loss in community-dwelling elderly.","volume":"71","author":"Vogiatzoglou","year":"2008","journal-title":"Neurology"},{"issue":"18","key":"yoi190040r21","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1161\/CIRCULATIONAHA.108.808675","article-title":"MTHFR 677 C>T polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.","volume":"119","author":"Antoniades","year":"2009","journal-title":"Circulation"},{"issue":"8","key":"yoi190040r22","doi-asserted-by":"publisher","first-page":"e0134766","DOI":"10.1371\/journal.pone.0134766","article-title":"Microstructural white matter properties mediate the association between APOE and perceptual speed in very old persons without dementia.","volume":"10","author":"Laukka","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"yoi190040r23","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/ajcn\/79.1.76","article-title":"Variation in plasma cystathionine and its relation to changes in plasma concentrations of homocysteine and methionine in healthy subjects during a 24-h observation period.","volume":"79","author":"Guttormsen","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"yoi190040r24","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1093\/ajcn\/80.3.641","article-title":"Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention.","volume":"80","author":"Bleie","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"12","key":"yoi190040r25","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1016\/j.neurobiolaging.2006.08.003","article-title":"A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer\u2019s disease.","volume":"28","author":"Selley","year":"2007","journal-title":"Neurobiol Aging"},{"key":"yoi190040r26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuint.2017.10.011","article-title":"Dysregulation of methionine metabolism in multiple sclerosis.","volume":"112","author":"Singhal","year":"2018","journal-title":"Neurochem Int"},{"key":"yoi190040r27","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.atherosclerosis.2018.03.038","article-title":"Plasma methionine and risk of acute myocardial infarction: Effect modification by established risk factors.","volume":"272","author":"Dhar","year":"2018","journal-title":"Atherosclerosis"},{"issue":"4","key":"yoi190040r28","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1160\/TH06-04-0187","article-title":"Low fasting methionine concentration as a novel risk factor for recurrent venous thrombosis.","volume":"96","author":"Keijzer","year":"2006","journal-title":"Thromb Haemost"},{"issue":"9","key":"yoi190040r29","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/oxfordjournals.aje.a008828","article-title":"Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate.","volume":"143","author":"Verhoef","year":"1996","journal-title":"Am J Epidemiol"},{"issue":"1","key":"yoi190040r30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10545-009-9006-9","article-title":"Dealing with methionine\/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur.","volume":"34","author":"Stipanuk","year":"2011","journal-title":"J Inherit Metab Dis"},{"issue":"23","key":"yoi190040r31","doi-asserted-by":"publisher","first-page":"9523","DOI":"10.1073\/pnas.1301816110","article-title":"Preventing Alzheimer\u2019s disease-related gray matter atrophy by B-vitamin treatment.","volume":"110","author":"Douaud","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"yoi190040r32","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1056\/NEJMoa0806142","article-title":"Age, neuropathology, and dementia.","volume":"360","author":"Savva","year":"2009","journal-title":"N Engl J Med"},{"issue":"2","key":"yoi190040r33","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers.","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"yoi190040r34","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ijcard.2018.04.083","article-title":"Plasma cystathionine and risk of acute myocardial infarction among patients with coronary heart disease: results from two independent cohorts.","volume":"266","author":"Dhar","year":"2018","journal-title":"Int J Cardiol"},{"issue":"5","key":"yoi190040r35","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/(ISSN)1531-8249","article-title":"Atherosclerosis and risk for dementia.","volume":"61","author":"van Oijen","year":"2007","journal-title":"Ann Neurol"},{"issue":"16","key":"yoi190040r36","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1001\/archinte.163.16.1933","article-title":"Association of elevated homocysteine levels with a higher risk of recurrent coronary events and mortality in patients with acute myocardial infarction.","volume":"163","author":"Matetzky","year":"2003","journal-title":"Arch Intern Med"},{"key":"yoi190040r18","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994","edition":"4th ed"}],"container-title":["JAMA Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/articlepdf\/2738056\/jamapsychiatry_hooshmand_2019_oi_190040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T11:32:05Z","timestamp":1573039925000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2738056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,1]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapsychiatry.2019.1694","relation":{},"ISSN":["2168-622X"],"issn-type":[{"value":"2168-622X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11,1]]}}}