{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:10:17Z","timestamp":1781140217642,"version":"3.54.1"},"reference-count":70,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2020,7,1]]},"DOI":"10.1001\/jamapsychiatry.2020.0527","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T17:01:29Z","timestamp":1586970089000},"page":"715","source":"Crossref","is-referenced-by-count":81,"title":["Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42\u202f998 Individuals"],"prefix":"10.1001","volume":"77","author":[{"given":"Wonuola A.","family":"Akingbuwa","sequence":"first","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"},{"name":"Amsterdam Public Health Research Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke R.","family":"Hammerschlag","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"},{"name":"Amsterdam Public Health Research Institute, Amsterdam, the Netherlands"},{"name":"Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eshim S.","family":"Jami","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"},{"name":"Amsterdam Public Health Research Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea G.","family":"Allegrini","sequence":"additional","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Karhunen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Sallis","sequence":"additional","affiliation":[{"name":"University of Bristol School of Psychological Science, Bristol, United Kingdom"},{"name":"MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom"},{"name":"Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Ask","sequence":"additional","affiliation":[{"name":"Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragna B.","family":"Askeland","sequence":"additional","affiliation":[{"name":"Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Baselmans","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Diemer","sequence":"additional","affiliation":[{"name":"Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona A.","family":"Hagenbeek","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"},{"name":"Amsterdam Public Health Research Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Havdahl","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom"},{"name":"Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway"},{"name":"Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouke-Jan","family":"Hottenga","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Mbarek","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"},{"name":"Qatar Genome Programme, Qatar Foundation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rivadeneira","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Erasmus MC, Department of Epidemiology, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Erasmus MC, Department of Internal Medicine, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Tesli","sequence":"additional","affiliation":[{"name":"Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"van Beijsterveldt","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerome","family":"Breen","sequence":"additional","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom"},{"name":"National Institute of Health Research Biomedical Research Centre, South London and Maudsley National Health Services Foundation Trust, London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathryn M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Thapar","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorret I.","family":"Boomsma","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"},{"name":"Amsterdam Public Health Research Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Kuja-Halkola","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Reichborn-Kjennerud","sequence":"additional","affiliation":[{"name":"Norwegian Institute of Public Health, Oslo, Norway"},{"name":"University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Magnus","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Rimfeld","sequence":"additional","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EIVIND","family":"Ystrom","sequence":"additional","affiliation":[{"name":"Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway"},{"name":"PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjo-Riitta","family":"Jarvelin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom"},{"name":"Medical Research Council\u2013Public Health England Centre for Environment and Health, Imperial College London, London, United Kingdom"},{"name":"Center for Life Course Health Research, University of Oulu, Oulu, Finland"},{"name":"Medical Research Center Oulu, Oulu, Finland"},{"name":"Institute of Biomedicine and Biocenter of Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Lundstrom","sequence":"additional","affiliation":[{"name":"Centre for Ethics Law and Mental Health, Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus R.","family":"Munaf\u00f2","sequence":"additional","affiliation":[{"name":"University of Bristol School of Psychological Science, Bristol, United Kingdom"},{"name":"MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom"},{"name":"National Institute of Health Research Biomedical Research Centre, University Hospitals Bristol National Health Services Foundation Trust, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Plomin","sequence":"additional","affiliation":[{"name":"Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Tiemeier","sequence":"additional","affiliation":[{"name":"Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, the Netherlands"},{"name":"Department of Social and Behavioral Science, Harvard T. H. Chan School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel G.","family":"Nivard","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Bartels","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"},{"name":"Amsterdam Public Health Research Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel M.","family":"Middeldorp","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"},{"name":"Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia"},{"name":"Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Services, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the Bipolar Disorder and Major Depressive Disorder Working Groups of the Psychiatric Genomics Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"7","key":"yoi200016r1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1001\/archpsyc.60.7.709","article-title":"Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort.","volume":"60","author":"Kim-Cohen","year":"2003","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"yoi200016r2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.31887\/DCNS.2009.11.1\/urao","article-title":"Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders.","volume":"11","author":"Rao","year":"2009","journal-title":"Dialogues Clin Neurosci"},{"issue":"4","key":"yoi200016r3","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/CHI.0b013e31816429d3","article-title":"New insights into the comorbidity between ADHD and major depression in adolescent and young adult females.","volume":"47","author":"Biederman","year":"2008","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"6","key":"yoi200016r4","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1002\/da.2013.30.issue-6","article-title":"Attention-deficit\/hyperactivity disorder in adolescence predicts onset of major depressive disorder through early adulthood.","volume":"30","author":"Meinzer","year":"2013","journal-title":"Depress Anxiety"},{"issue":"7","key":"yoi200016r5","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s10802-014-9867-8","article-title":"Do childhood externalizing disorders predict adult depression? a meta-analysis.","volume":"42","author":"Loth","year":"2014","journal-title":"J Abnorm Child Psychol"},{"issue":"11","key":"yoi200016r6","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1002\/da.2016.33.issue-11","article-title":"Educational attainment as a protective factor for psychiatric disorders: findings from a nationally representative longitudinal study.","volume":"33","author":"Erickson","year":"2016","journal-title":"Depress Anxiety"},{"issue":"4","key":"yoi200016r7","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1600-0447.2010.01568.x","article-title":"A systematic review of prospective studies on attention problems and academic achievement.","volume":"122","author":"Polderman","year":"2010","journal-title":"Acta Psychiatr Scand"},{"issue":"9","key":"yoi200016r8","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.jpsychires.2008.01.016","article-title":"Mental disorders and subsequent educational attainment in a US national sample.","volume":"42","author":"Breslau","year":"2008","journal-title":"J Psychiatr Res"},{"issue":"3","key":"yoi200016r9","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/jcpp.12371","article-title":"Annual research review: Optimal outcomes of child and adolescent mental illness.","volume":"56","author":"Costello","year":"2015","journal-title":"J Child Psychol Psychiatry"},{"key":"yoi200016r10","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1016\/S1389-9457(08)70004-2","article-title":"Insomnia and comorbid psychiatric disorders.","volume":"8","author":"Riemann","year":"2007","journal-title":"Sleep Med"},{"issue":"11","key":"yoi200016r11","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.5665\/sleep.4168","article-title":"Mental health antecedents of early midlife insomnia: evidence from a four-decade longitudinal study.","volume":"37","author":"Goldman-Mellor","year":"2014","journal-title":"Sleep"},{"issue":"3","key":"yoi200016r12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s10519-013-9589-7","article-title":"Exploring the association between well-being and psychopathology in adolescents.","volume":"43","author":"Bartels","year":"2013","journal-title":"Behav Genet"},{"issue":"10","key":"yoi200016r13","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1001\/archpsyc.63.10.1113","article-title":"Personality and major depression: a Swedish longitudinal, population-based twin study.","volume":"63","author":"Kendler","year":"2006","journal-title":"Arch Gen Psychiatry"},{"issue":"13","key":"yoi200016r14","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1017\/S0033291718002982","article-title":"Joint factorial structure of psychopathology and personality.","volume":"49","author":"Rosenstr\u00f6m","year":"2019","journal-title":"Psychol Med"},{"issue":"1","key":"yoi200016r15","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s12888-014-0210-2","article-title":"Neuroticism developmental courses\u2014implications for depression, anxiety and everyday emotional experience; a prospective study from adolescence to young adulthood.","volume":"14","author":"Aldinger","year":"2014","journal-title":"BMC Psychiatry"},{"issue":"4","key":"yoi200016r16","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1177\/0004867415569796","article-title":"Personality characteristics in childhood and outcomes in adulthood: findings from a 30 year longitudinal study.","volume":"49","author":"Newton-Howes","year":"2015","journal-title":"Aust N Z J Psychiatry"},{"issue":"6","key":"yoi200016r17","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1017\/S0033291703001697","article-title":"The associations between psychopathology and being overweight: a 20-year prospective study.","volume":"34","author":"Hasler","year":"2004","journal-title":"Psychol Med"},{"issue":"3","key":"yoi200016r18","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1001\/archpedi.160.3.285","article-title":"Association of depression and anxiety disorders with weight change in a prospective community-based study of children followed up into adulthood.","volume":"160","author":"Anderson","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"6","key":"yoi200016r19","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/ijo.2010.214","article-title":"Association between attention-deficit\/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: a population-based study.","volume":"35","author":"Fuemmeler","year":"2011","journal-title":"Int J Obes (Lond)"},{"issue":"7","key":"yoi200016r20","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/ng.3285","article-title":"Meta-analysis of the heritability of human traits based on fifty years of twin studies.","volume":"47","author":"Polderman","year":"2015","journal-title":"Nat Genet"},{"issue":"6395","key":"yoi200016r21","article-title":"Analysis of shared heritability in common disorders of the brain.","volume":"360","author":"Anttila","year":"2018","journal-title":"Science"},{"issue":"3","key":"yoi200016r22","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/s41588-018-0333-3","article-title":"Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.","volume":"51","author":"Jansen","year":"2019","journal-title":"Nat Genet"},{"issue":"1","key":"yoi200016r23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jaac.2012.10.009","article-title":"Genetic and environmental stability in attention problems across the lifespan: evidence from the Netherlands twin register.","volume":"52","author":"Kan","year":"2013","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"5","key":"yoi200016r24","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1017\/S003329171400213X","article-title":"Stability in symptoms of anxiety and depression as a function of genotype and environment: a longitudinal twin study from ages 3 to 63 years.","volume":"45","author":"Nivard","year":"2015","journal-title":"Psychol Med"},{"issue":"1","key":"yoi200016r25","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41398-018-0269-5","article-title":"Extracting stability increases the SNP heritability of emotional problems in young people.","volume":"8","author":"Cheesman","year":"2018","journal-title":"Transl Psychiatry"},{"issue":"3","key":"yoi200016r26","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1176\/appi.ajp.2009.09070977","article-title":"Psychiatric disorders in preschool offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring Study (BIOS).","volume":"167","author":"Birmaher","year":"2010","journal-title":"Am J Psychiatry"},{"issue":"4","key":"yoi200016r27","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/bdi.2005.7.issue-4","article-title":"Five-year prospective outcome of psychopathology in the adolescent offspring of bipolar parents.","volume":"7","author":"Hillegers","year":"2005","journal-title":"Bipolar Disord"},{"issue":"5","key":"yoi200016r28","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1176\/appi.ajp.2012.12030401","article-title":"The Dutch bipolar offspring study: 12-year follow-up.","volume":"170","author":"Mesman","year":"2013","journal-title":"Am J Psychiatry"},{"issue":"10","key":"yoi200016r29","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/jcpp.12295","article-title":"Research review: polygenic methods and their application to psychiatric traits.","volume":"55","author":"Wray","year":"2014","journal-title":"J Child Psychol Psychiatry"},{"issue":"9","key":"yoi200016r30","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/mp.2015.126","article-title":"Phenome-wide analysis of genome-wide polygenic scores.","volume":"21","author":"Krapohl","year":"2016","journal-title":"Mol Psychiatry"},{"issue":"13","key":"yoi200016r31","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1017\/S0033291717003634","article-title":"The impact of schizophrenia and mood disorder risk alleles on emotional problems: investigating change from childhood to middle age.","volume":"48","author":"Riglin","year":"2018","journal-title":"Psychol Med"},{"issue":"1","key":"yoi200016r32","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/jcpp.2018.59.issue-1","article-title":"Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population.","volume":"59","author":"Jansen","year":"2018","journal-title":"J Child Psychol Psychiatry"},{"issue":"6","key":"yoi200016r33","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/ajmg.b.32254","article-title":"Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children.","volume":"165B","author":"de Zeeuw","year":"2014","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"2","key":"yoi200016r34","first-page":"421","article-title":"Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population.","volume":"46","author":"Stergiakouli","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"5","key":"yoi200016r35","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","article-title":"Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.","volume":"50","author":"Wray","year":"2018","journal-title":"Nat Genet"},{"issue":"3","key":"yoi200016r36","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/s41593-018-0326-7","article-title":"Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.","volume":"22","author":"Howard","year":"2019","journal-title":"Nat Neurosci"},{"issue":"5","key":"yoi200016r37","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/s41588-019-0397-8","article-title":"Genome-wide association study identifies 30 loci associated with bipolar disorder.","volume":"51","author":"Stahl","year":"2019","journal-title":"Nat Genet"},{"issue":"8","key":"yoi200016r38","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/s41588-018-0147-3","article-title":"Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.","volume":"50","author":"Lee","year":"2018","journal-title":"Nat Genet"},{"issue":"20","key":"yoi200016r39","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1093\/hmg\/ddy271","article-title":"Meta-analysis of genome-wide association studies for height and body mass index in ~700?000 individuals of European ancestry.","volume":"27","author":"Yengo","year":"2018","journal-title":"Hum Mol Genet"},{"issue":"3","key":"yoi200016r40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003348","article-title":"Power and predictive accuracy of polygenic risk scores.","volume":"9","author":"Dudbridge","year":"2013","journal-title":"PLoS Genet"},{"issue":"6","key":"yoi200016r41","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/ng.3552","article-title":"Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.","volume":"48","author":"Okbay","year":"2016","journal-title":"Nat Genet"},{"issue":"11","key":"yoi200016r42","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/ng.3888","article-title":"Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits.","volume":"49","author":"Hammerschlag","year":"2017","journal-title":"Nat Genet"},{"issue":"4","key":"yoi200016r43","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ajhg.2015.09.001","article-title":"Modeling linkage disequilibrium increases accuracy of polygenic risk scores.","volume":"97","author":"Vilhj\u00e1lmsson","year":"2015","journal-title":"Am J Hum Genet"},{"issue":"5","key":"yoi200016r44","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/jcpp.1997.38.issue-5","article-title":"The Strengths and Difficulties Questionnaire: a research note.","volume":"38","author":"Goodman","year":"1997","journal-title":"J Child Psychol Psychiatry"},{"issue":"1","key":"yoi200016r45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-244X-10-1","article-title":"The autism\u2014tics, AD\/HD and other comorbidities inventory (A-TAC): further validation of a telephone interview for epidemiological research.","volume":"10","author":"Larson","year":"2010","journal-title":"BMC Psychiatry"},{"issue":"4","key":"yoi200016r46","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1097\/00004583-199704000-00018","article-title":"The screen for child anxiety related emotional disorders (SCARED): scale construction and psychometric characteristics.","volume":"36","author":"Birmaher","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"3","key":"yoi200016r47","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s10802-006-9027-x","article-title":"The Short Mood and Feelings Questionnaire (SMFQ): a unidimensional item response theory and categorical data factor analysis of self-report ratings from a community sample of 7-through 11-year-old children.","volume":"34","author":"Sharp","year":"2006","journal-title":"J Abnorm Child Psychol"},{"issue":"4","key":"yoi200016r49","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s11126-005-4966-x","article-title":"A rating scale for disruptive behavior disorders, based on the DSM-IV item pool.","volume":"76","author":"Silva","year":"2005","journal-title":"Psychiatr Q"},{"issue":"4","key":"yoi200016r50","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1023\/A:1022602400621","article-title":"The revised Conners\u2019 Parent Rating Scale (CPRS-R): factor structure, reliability, and criterion validity.","volume":"26","author":"Conners","year":"1998","journal-title":"J Abnorm Child Psychol"},{"issue":"3","key":"yoi200016r51","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/ejhg.2014.94","article-title":"Sandwich corrected standard errors in family-based genome-wide association studies.","volume":"23","author":"Minica","year":"2015","journal-title":"Eur J Hum Genet"},{"issue":"3","key":"yoi200016r52","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package.","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Softw"},{"issue":"6","key":"yoi200016r53","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1093\/schbul\/sbx031","article-title":"Genetic overlap between schizophrenia and developmental psychopathology: longitudinal and multivariate polygenic risk prediction of common psychiatric traits during development.","volume":"43","author":"Nivard","year":"2017","journal-title":"Schizophr Bull"},{"issue":"4","key":"yoi200016r54","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1086\/383251","article-title":"A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.","volume":"74","author":"Nyholt","year":"2004","journal-title":"Am J Hum Genet"},{"issue":"12","key":"yoi200016r56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v034.i12","article-title":"glmulti: an R package for easy automated model selection with (generalized) linear models.","volume":"34","author":"Calcagno","year":"2010","journal-title":"J Stat Softw"},{"issue":"1","key":"yoi200016r57","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3758\/BF03206482","article-title":"AIC model selection using Akaike weights.","volume":"11","author":"Wagenmakers","year":"2004","journal-title":"Psychon Bull Rev"},{"issue":"1","key":"yoi200016r58","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41588-018-0269-7","article-title":"Discovery of the first genome-wide significant risk loci for attention deficit\/hyperactivity disorder.","volume":"51","author":"Demontis","year":"2019","journal-title":"Nat Genet"},{"issue":"261","key":"yoi200016r59","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fpsyt.2018.00261","article-title":"Unraveling the genetic and environmental relationship between well-being and depressive symptoms throughout the lifespan.","volume":"9","author":"Baselmans","year":"2018","journal-title":"Front Psychiatry"},{"key":"yoi200016r60","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.jad.2018.12.091","article-title":"Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood.","volume":"246","author":"Mistry","year":"2019","journal-title":"J Affect Disord"},{"issue":"3","key":"yoi200016r61","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1001\/jamapsychiatry.2018.3652","article-title":"Association of genetic risk factors for psychiatric disorders and traits of these disorders in a Swedish population twin sample.","volume":"76","author":"Taylor","year":"2019","journal-title":"JAMA Psychiatry"},{"issue":"1-3","key":"yoi200016r62","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jad.2007.01.004","article-title":"Psychopathology in children of bipolar parents.","volume":"102","author":"Singh","year":"2007","journal-title":"J Affect Disord"},{"issue":"3","key":"yoi200016r63","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1001\/archgenpsychiatry.2008.546","article-title":"Lifetime psychiatric disorders in school-aged offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring study.","volume":"66","author":"Birmaher","year":"2009","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"yoi200016r64","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ajhg.2019.06.006","article-title":"Comparing within- and between-family polygenic score prediction.","volume":"105","author":"Selzam","year":"2019","journal-title":"Am J Hum Genet"},{"key":"yoi200016r65","article-title":"Variable prediction accuracy of polygenic scores within an ancestry group.","author":"Mostafavi","year":"2019","journal-title":"bioRxiv"},{"issue":"12","key":"yoi200016r66","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1093\/aje\/kww009","article-title":"Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study.","volume":"183","author":"Martin","year":"2016","journal-title":"Am J Epidemiol"},{"issue":"4","key":"yoi200016r67","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1093\/ije\/dyy060","article-title":"Exploring the association of genetic factors with participation in the Avon Longitudinal Study of Parents and Children.","volume":"47","author":"Taylor","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"1","key":"yoi200016r68","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/jcpp.v61.1","article-title":"The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence.","volume":"61","author":"Allegrini","year":"2020","journal-title":"J Child Psychol Psychiatry"},{"issue":"2","key":"yoi200016r69","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1176\/appi.ajp.2019.18060721","article-title":"Polygenic risk score contribution to psychosis prediction in a target population of persons at clinical high risk.","volume":"177","author":"Perkins","year":"2020","journal-title":"Am J Psychiatry"},{"issue":"7","key":"yoi200016r70","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrg.2016.27","article-title":"Developing and evaluating polygenic risk prediction models for stratified disease prevention.","volume":"17","author":"Chatterjee","year":"2016","journal-title":"Nat Rev Genet"},{"key":"yoi200016r48","article-title":"Achenbach system of empirically based assessment (ASEBA).","volume-title":"The Encyclopedia of Clinical Psychology","author":"Achenbach","year":"2014"},{"key":"yoi200016r55","doi-asserted-by":"crossref","unstructured":"Derringer? J. A simple correction for non-independent tests. Published March 21, 2018. Accessed March 2, 2020. https:\/\/osf.io\/re5w2\/","DOI":"10.31234\/osf.io\/f2tyw"}],"container-title":["JAMA Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/articlepdf\/2763801\/jamapsychiatry_akingbuwa_2020_oi_200016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T11:01:46Z","timestamp":1666350106000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2763801"}},"subtitle":["A Meta-analysis"],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":70,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapsychiatry.2020.0527","relation":{},"ISSN":["2168-622X"],"issn-type":[{"value":"2168-622X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7,1]]}}}