{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:27:21Z","timestamp":1790623641950,"version":"4.1.0"},"reference-count":69,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2021,2,1]]},"DOI":"10.1001\/jamapsychiatry.2020.3554","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T16:31:25Z","timestamp":1605112285000},"page":"151","source":"Crossref","is-referenced-by-count":177,"title":["Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders"],"prefix":"10.1001","volume":"78","author":[{"given":"Daniel B.","family":"Rosoff","sequence":"first","affiliation":[{"name":"Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Davey","family":"Smith","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk W.","family":"Lohoff","sequence":"additional","affiliation":[{"name":"Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"20","key":"yoi200065r2","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000015425","article-title":"Current perspectives on the opioid crisis in the US healthcare system: a comprehensive literature review.","volume":"98","author":"Stoicea","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"7","key":"yoi200065r5","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1001\/jamapsychiatry.2014.366","article-title":"The changing face of heroin use in the United States: a retrospective analysis of the past 50 years.","volume":"71","author":"Cicero","year":"2014","journal-title":"JAMA Psychiatry"},{"issue":"4","key":"yoi200065r6","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/01.j.pain.0000460357.01998.f1","article-title":"Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis.","volume":"156","author":"Vowles","year":"2015","journal-title":"Pain"},{"issue":"20","key":"yoi200065r7","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1056\/NEJMra025411","article-title":"Opioid therapy for chronic pain.","volume":"349","author":"Ballantyne","year":"2003","journal-title":"N Engl J Med"},{"issue":"4765","key":"yoi200065r8","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1126\/science.3016896","article-title":"Psychotomimesis mediated by kappa opiate receptors.","volume":"233","author":"Pfeiffer","year":"1986","journal-title":"Science"},{"issue":"3","key":"yoi200065r9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1521-0391.2012.12008.x","article-title":"Frequency and severity of comorbid mood and anxiety disorders in prescription opioid dependence.","volume":"22","author":"Gros","year":"2013","journal-title":"Am J Addict"},{"issue":"4","key":"yoi200065r10","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3122\/jabfm.2017.04.170112","article-title":"Prescription opioid use among adults with mental health disorders in the United States.","volume":"30","author":"Davis","year":"2017","journal-title":"J Am Board Fam Med"},{"issue":"4","key":"yoi200065r11","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41380-018-0117-2","article-title":"Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches.","volume":"24","author":"Peci\u00f1a","year":"2019","journal-title":"Mol Psychiatry"},{"issue":"2","key":"yoi200065r12","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1001\/jamapsychiatry.2018.3126","article-title":"Prevention and treatment of opioid misuse and addiction: a review.","volume":"76","author":"Volkow","year":"2019","journal-title":"JAMA Psychiatry"},{"issue":"9","key":"yoi200065r13","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.jpain.2015.05.010","article-title":"Symptoms of depression are associated with opioid use regardless of pain severity and physical functioning among treatment-seeking patients with chronic pain.","volume":"16","author":"Goesling","year":"2015","journal-title":"J Pain"},{"issue":"1-3","key":"yoi200065r14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.pain.2005.09.020","article-title":"Regular use of prescribed opioids: association with common psychiatric disorders.","volume":"119","author":"Sullivan","year":"2005","journal-title":"Pain"},{"issue":"11","key":"yoi200065r15","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1097\/j.pain.0000000000000650","article-title":"Disproportionate longer-term opioid use among U.S. adults with mood disorders.","volume":"157","author":"Halbert","year":"2016","journal-title":"Pain"},{"issue":"4","key":"yoi200065r16","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1001\/archgenpsychiatry.2011.160","article-title":"Prevalence, persistence, and sociodemographic correlates of DSM-IV disorders in the National Comorbidity Survey Replication Adolescent Supplement.","volume":"69","author":"Kessler","year":"2012","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"yoi200065r17","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1001\/jamapsychiatry.2014.2502","article-title":"Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis.","volume":"72","author":"Walker","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"yoi200065r18","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1097\/j.pain.0000000000000763","article-title":"New-onset depression following stable, slow, and rapid rate of prescription opioid dose escalation.","volume":"158","author":"Salas","year":"2017","journal-title":"Pain"},{"issue":"3","key":"yoi200065r19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s11606-013-2648-1","article-title":"Prescription opioid analgesics increase the risk of depression.","volume":"29","author":"Scherrer","year":"2014","journal-title":"J Gen Intern Med"},{"key":"yoi200065r20","doi-asserted-by":"crossref","DOI":"10.1136\/rapm-2019-100785","article-title":"Risk factors for new-onset depression or anxiety following total joint arthroplasty: the role of chronic opioid use.","author":"Wilson","year":"2019","journal-title":"Reg Anesth Pain Med"},{"issue":"5","key":"yoi200065r21","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/pds.v25.5","article-title":"New depression diagnosis following prescription of codeine, hydrocodone or oxycodone.","volume":"25","author":"Scherrer","year":"2016","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"11","key":"yoi200065r22","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/0895-4356(91)90155-3","article-title":"How independent are \u201cindependent\u201d effects? relative risk estimation when correlated exposures are measured imprecisely.","volume":"44","author":"Phillips","year":"1991","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"yoi200065r23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"\u2018Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int J Epidemiol"},{"issue":"9977","key":"yoi200065r24","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/S0140-6736(15)60742-5","article-title":"The history and fate of the gold standard.","volume":"385","author":"Jones","year":"2015","journal-title":"Lancet"},{"issue":"R1","key":"yoi200065r26","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies.","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"2","key":"yoi200065r27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10654-020-00622-7","article-title":"Mendel\u2019s laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues.","volume":"35","author":"Davey Smith","year":"2020","journal-title":"Eur J Epidemiol"},{"issue":"1","key":"yoi200065r28","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1038\/s41467-019-09572-5","article-title":"Genome-wide association study of medication-use and associated disease in the UK Biobank.","volume":"10","author":"Wu","year":"2019","journal-title":"Nat Commun"},{"issue":"5","key":"yoi200065r29","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","article-title":"Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.","volume":"50","author":"Wray","year":"2018","journal-title":"Nat Genet"},{"issue":"9","key":"yoi200065r30","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1001\/jamapsychiatry.2019.1119","article-title":"Genetic variants associated with anxiety and stress-related disorders: a genome-wide association study and mouse-model study.","volume":"76","author":"Meier","year":"2019","journal-title":"JAMA Psychiatry"},{"issue":"10","key":"yoi200065r31","doi-asserted-by":"publisher","first-page":"e106907","DOI":"10.1371\/journal.pone.0106907","article-title":"The association of depression and anxiety with pain: a study from NESDA.","volume":"9","author":"de Heer","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"yoi200065r32","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/00002508-199706000-00006","article-title":"Chronic pain-associated depression: antecedent or consequence of chronic pain? a review.","volume":"13","author":"Fishbain","year":"1997","journal-title":"Clin J Pain"},{"issue":"3","key":"yoi200065r33","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1093\/ije\/dyy262","article-title":"An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings.","volume":"48","author":"Sanderson","year":"2019","journal-title":"Int J Epidemiol"},{"issue":"1","key":"yoi200065r35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/ije\/dyx204","article-title":"Software application profile: PHESANT: a tool for performing automated phenome scans in UK Biobank.","volume":"47","author":"Millard","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"4","key":"yoi200065r36","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/aje\/kwu283","article-title":"Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects.","volume":"181","author":"Burgess","year":"2015","journal-title":"Am J Epidemiol"},{"issue":"7","key":"yoi200065r37","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/gepi.2016.40.issue-7","article-title":"Bias due to participant overlap in two-sample Mendelian randomization.","volume":"40","author":"Burgess","year":"2016","journal-title":"Genet Epidemiol"},{"key":"yoi200065r38","doi-asserted-by":"publisher","first-page":"7","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome.","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"issue":"R2","key":"yoi200065r39","doi-asserted-by":"publisher","first-page":"R195","DOI":"10.1093\/hmg\/ddy163","article-title":"Evaluating the potential role of pleiotropy in Mendelian randomization studies.","volume":"27","author":"Hemani","year":"2018","journal-title":"Hum Mol Genet"},{"issue":"2","key":"yoi200065r40","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"4","key":"yoi200065r41","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.2016.40.issue-4","article-title":"Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator.","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"11","key":"yoi200065r42","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1002\/sim.v36.11","article-title":"A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization.","volume":"36","author":"Bowden","year":"2017","journal-title":"Stat Med"},{"issue":"3","key":"yoi200065r43","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1093\/ije\/dyy258","article-title":"Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption.","volume":"48","author":"Bowden","year":"2019","journal-title":"Int J Epidemiol"},{"issue":"5","key":"yoi200065r44","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"issue":"29","key":"yoi200065r45","doi-asserted-by":"publisher","first-page":"4705","DOI":"10.1002\/sim.v36.29","article-title":"Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy.","volume":"36","author":"Rees","year":"2017","journal-title":"Stat Med"},{"issue":"7748","key":"yoi200065r46","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/d41586-019-00857-9","article-title":"Scientists rise up against statistical significance.","volume":"567","author":"Amrhein","year":"2019","journal-title":"Nature"},{"issue":"5","key":"yoi200065r47","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method.","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"yoi200065r48","doi-asserted-by":"crossref","DOI":"10.1001\/jamapsychiatry.2020.1206","article-title":"Association of OPRM1 functional coding variant with opioid use disorder: a genome-wide association study.","author":"Zhou","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"yoi200065r49","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1146\/annurev.neuro.29.051605.113009","article-title":"Neural mechanisms of addiction: the role of reward-related learning and memory.","volume":"29","author":"Hyman","year":"2006","journal-title":"Annu Rev Neurosci"},{"issue":"2","key":"yoi200065r50","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/0304-3940(93)90329-J","article-title":"Modulation of morphine-induced sensitization by endogenous kappa opioid systems in the rat.","volume":"153","author":"Spanagel","year":"1993","journal-title":"Neurosci Lett"},{"issue":"7","key":"yoi200065r51","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/aps.2015.32","article-title":"The role of the dynorphin\/? opioid receptor system in anxiety.","volume":"36","author":"Hang","year":"2015","journal-title":"Acta Pharmacol Sin"},{"issue":"12","key":"yoi200065r52","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1038\/sj.npp.1301675","article-title":"The role of amygdalar mu-opioid receptors in anxiety-related responses in two rat models.","volume":"33","author":"Wilson","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"yoi200065r53","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/S0306-4522(98)00251-6","article-title":"Expression of mu, kappa, and delta opioid receptor messenger RNA in the human CNS: a 33P in situ hybridization study.","volume":"88","author":"Peckys","year":"1999","journal-title":"Neuroscience"},{"issue":"12","key":"yoi200065r54","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1176\/appi.ajp.2018.18020138","article-title":"Attenuation of antidepressant effects of ketamine by opioid receptor antagonism.","volume":"175","author":"Williams","year":"2018","journal-title":"Am J Psychiatry"},{"issue":"3","key":"yoi200065r55","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.tins.2012.11.002","article-title":"Opioid receptors: distinct roles in mood disorders.","volume":"36","author":"Lutz","year":"2013","journal-title":"Trends Neurosci"},{"issue":"170","key":"yoi200065r56","first-page":"170","article-title":"The kappa opioid receptor: from addiction to depression, and back.","volume":"5","author":"Lalanne","year":"2014","journal-title":"Front Psychiatry"},{"issue":"3","key":"yoi200065r57","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.pharmthera.2009.05.008","article-title":"Kappa-opioid ligands in the study and treatment of mood disorders.","volume":"123","author":"Carlezon","year":"2009","journal-title":"Pharmacol Ther"},{"issue":"4","key":"yoi200065r58","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1370\/afm.1371","article-title":"Depression and prescription opioid misuse among chronic opioid therapy recipients with no history of substance abuse.","volume":"10","author":"Grattan","year":"2012","journal-title":"Ann Fam Med"},{"key":"yoi200065r59","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2147\/SAR","article-title":"Opioid-use disorder among patients on long-term opioid therapy: impact of final DSM-5 diagnostic criteria on prevalence and correlates.","volume":"6","author":"Boscarino","year":"2015","journal-title":"Subst Abuse Rehabil"},{"issue":"6","key":"yoi200065r60","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/HRP.0000000000000198","article-title":"Pain and depression: a systematic review.","volume":"26","author":"IsHak","year":"2018","journal-title":"Harv Rev Psychiatry"},{"issue":"23","key":"yoi200065r61","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.2165\/00003495-200464230-00001","article-title":"NSAID-related psychiatric adverse events: who is at risk?","volume":"64","author":"Onder","year":"2004","journal-title":"Drugs"},{"issue":"1","key":"yoi200065r62","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2190\/1B32-79EA-B6H5-395V","article-title":"Nonsteroidal anti-inflammatory drugs and severe psychiatric side effects.","volume":"26","author":"Browning","year":"1996","journal-title":"Int J Psychiatry Med"},{"issue":"375","key":"yoi200065r63","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3389\/fpsyt.2019.00375","article-title":"COX-2 inhibitors, aspirin, and other potential anti-inflammatory treatments for psychiatric disorders.","volume":"10","author":"M\u00fcller","year":"2019","journal-title":"Front Psychiatry"},{"issue":"3","key":"yoi200065r64","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1093\/ije\/dyw127","article-title":"Commentary: two-sample Mendelian randomization: opportunities and challenges.","volume":"45","author":"Lawlor","year":"2016","journal-title":"Int J Epidemiol"},{"issue":"4","key":"yoi200065r65","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.2016.40.issue-4","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator.","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"6","key":"yoi200065r66","first-page":"1866","article-title":"Triangulation in aetiological epidemiology.","volume":"45","author":"Lawlor","year":"2016","journal-title":"Int J Epidemiol"},{"issue":"4","key":"yoi200065r67","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1093\/ije\/dyy131","article-title":"Investigating causality in associations between education and smoking: a two-sample Mendelian randomization study.","volume":"47","author":"Gage","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"4","key":"yoi200065r68","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1001\/jamapsychiatry.2018.4175","article-title":"Assessment of bidirectional relationships between physical activity and depression among adults: a 2-sample mendelian randomization study.","volume":"76","author":"Choi","year":"2019","journal-title":"JAMA Psychiatry"},{"issue":"9","key":"yoi200065r69","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/aje\/kwx246","article-title":"Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population.","volume":"186","author":"Fry","year":"2017","journal-title":"Am J Epidemiol"},{"key":"yoi200065r3","volume-title":"Drug and Opioid-Involved Overdose Deaths: United States, 2013\u20132017. MMWR Morb Mortal Wkly Rep website","author":"Scholl","year":"2019"},{"key":"yoi200065r1","unstructured":"US Centers for Disease Control and Prevention. Understanding the epidemic: drug overdose deaths in the United States continue to increase in 2015. Published 2011. Updated December 19, 2018. Accessed November 5, 2019. https:\/\/www.cdc.gov\/drugoverdose\/epidemic\/"},{"key":"yoi200065r4","unstructured":"NIDA. Opioid overdose crisis. Published 2019. Accessed November 6, 2019. https:\/\/www.drugabuse.gov\/drugs-abuse\/opioids\/opioid-overdose-crisis."},{"key":"yoi200065r25","doi-asserted-by":"crossref","unstructured":"Fallon? UB B-SY, Davey Smith? G. Homocysteine and coronary heart disease. Published 2001. Accessed July 20 2020. https:\/\/heart.bmj.com\/content\/85\/2\/153.responses","DOI":"10.1136\/heart.85.2.153"},{"key":"yoi200065r34","unstructured":"Elsworth? B, Mitchell? R, Raistrick? CA, . MRC IEU UK Biobank GWAS pipeline version 1. Published 2017. Accessed Feb 2, 2019. https:\/\/data.bris.ac.uk\/data\/dataset\/2fahpksont1zi26xosyamqo8rr"}],"container-title":["JAMA Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/articlepdf\/2772881\/jamapsychiatry_rosoff_2020_oi_200065_1611765284.95856.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T05:59:04Z","timestamp":1612591144000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2772881"}},"subtitle":["A Multivariable Mendelian Randomization Analysis"],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapsychiatry.2020.3554","relation":{},"ISSN":["2168-622X"],"issn-type":[{"value":"2168-622X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,1]]}}}