{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:50:20Z","timestamp":1793278220303,"version":"4.5.0"},"reference-count":71,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2021,4,1]]},"DOI":"10.1001\/jamapsychiatry.2020.4172","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T08:28:13Z","timestamp":1610612893000},"page":"387","source":"Crossref","is-referenced-by-count":81,"title":["Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status"],"prefix":"10.1001","volume":"78","author":[{"given":"Esben","family":"Agerbo","sequence":"first","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"National Centre for Register-Based Research (NCRR), Aarhus University, Aarhus, Denmark"},{"name":"Centre for Integrated Register-based Research at Aarhus University (CIRRAU), Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina B.","family":"Trabjerg","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"National Centre for Register-Based Research (NCRR), Aarhus University, Aarhus, Denmark"},{"name":"Centre for Integrated Register-based Research at Aarhus University (CIRRAU), Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders D.","family":"B\u00f8rglum","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark"},{"name":"Center for Genomics and Personalized Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Schork","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona"},{"name":"Institute of Biological Psychiatry, Mental Health Center Sct Hans, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarni J.","family":"Vilhj\u00e1lmsson","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"National Centre for Register-Based Research (NCRR), Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"National Centre for Register-Based Research (NCRR), Aarhus University, Aarhus, Denmark"},{"name":"Centre for Integrated Register-based Research at Aarhus University (CIRRAU), Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hakulinen","sequence":"additional","affiliation":[{"name":"Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Albi\u00f1ana","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"National Centre for Register-Based Research (NCRR), Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Hougaard","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Grove","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark"},{"name":"Center for Genomics and Personalized Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"McGrath","sequence":"additional","affiliation":[{"name":"National Centre for Register-Based Research (NCRR), Aarhus University, Aarhus, Denmark"},{"name":"Queensland Brain Institute, University of Queensland, St Lucia, Queensland, Australia"},{"name":"Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Bybjerg-Grauholm","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Mors","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"Psychosis Research Unit, Aarhus University Hospital\u2013Psychiatry, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleguer","family":"Plana-Ripoll","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Werge","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"Institute of Biological Psychiatry, Mental Health Center Sct Hans, Roskilde, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Center for GeoGenetic, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi R.","family":"Wray","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preben Bo","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"National Centre for Register-Based Research (NCRR), Aarhus University, Aarhus, Denmark"},{"name":"Centre for Integrated Register-based Research at Aarhus University (CIRRAU), Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Musliner","sequence":"additional","affiliation":[{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark"},{"name":"National Centre for Register-Based Research (NCRR), Aarhus University, Aarhus, Denmark"},{"name":"Centre for Integrated Register-based Research at Aarhus University (CIRRAU), Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"key":"yoi200078r1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-clinpsy-050817-084811","article-title":"Risk factors for depression: an autobiographical review.","volume":"14","author":"Hammen","year":"2018","journal-title":"Annu Rev Clin Psychol"},{"issue":"10161","key":"yoi200078r2","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression.","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"issue":"4","key":"yoi200078r3","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1001\/jamapsychiatry.2017.4602","article-title":"Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States.","volume":"75","author":"Hasin","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"yoi200078r4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev-publhealth-031912-114409","article-title":"The epidemiology of depression across cultures.","volume":"34","author":"Kessler","year":"2013","journal-title":"Annu Rev Public Health"},{"issue":"5","key":"yoi200078r5","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1001\/jamapsychiatry.2014.16","article-title":"A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders.","volume":"71","author":"Pedersen","year":"2014","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"yoi200078r6","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1001\/jamapsychiatry.2017.3828","article-title":"Sources of parent-offspring resemblance for major depression in a national Swedish extended adoption study.","volume":"75","author":"Kendler","year":"2018","journal-title":"JAMA Psychiatry"},{"issue":"10","key":"yoi200078r7","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1176\/appi.ajp.157.10.1552","article-title":"Genetic epidemiology of major depression: review and meta-analysis.","volume":"157","author":"Sullivan","year":"2000","journal-title":"Am J Psychiatry"},{"issue":"3","key":"yoi200078r8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1001\/jamapsychiatry.2018.3658","article-title":"Exploring comorbidity within mental disorders among a Danish national population.","volume":"76","author":"Plana-Ripoll","year":"2019","journal-title":"JAMA Psychiatry"},{"issue":"4","key":"yoi200078r9","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41588-020-0594-5","article-title":"Minimal phenotyping yields genome-wide association signals of low specificity for major depression.","volume":"52","author":"Cai","year":"2020","journal-title":"Nat Genet"},{"issue":"3","key":"yoi200078r10","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/s41593-018-0326-7","article-title":"Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.","volume":"22","author":"Howard","year":"2019","journal-title":"Nat Neurosci"},{"issue":"3","key":"yoi200078r11","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41593-018-0320-0","article-title":"A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment.","volume":"22","author":"Schork","year":"2019","journal-title":"Nat Neurosci"},{"issue":"5","key":"yoi200078r12","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","article-title":"Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.","volume":"50","author":"Wray","year":"2018","journal-title":"Nat Genet"},{"issue":"8","key":"yoi200078r13","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1001\/archgenpsychiatry.2010.86","article-title":"Full spectrum of psychiatric outcomes among offspring with parental history of mental disorder.","volume":"67","author":"Dean","year":"2010","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"yoi200078r14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/ije\/31.2.359","article-title":"Socioeconomic status in childhood and the lifetime risk of major depression.","volume":"31","author":"Gilman","year":"2002","journal-title":"Int J Epidemiol"},{"issue":"11","key":"yoi200078r15","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1002\/da.v36.11","article-title":"Bipolar disorder and depression in early adulthood and long-term employment, income, and educational attainment: a nationwide cohort study of 2,390,127 individuals.","volume":"36","author":"Hakulinen","year":"2019","journal-title":"Depress Anxiety"},{"issue":"1","key":"yoi200078r16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.neuron.2019.03.022","article-title":"Uncovering the genetic architecture of major depression.","volume":"102","author":"McIntosh","year":"2019","journal-title":"Neuron"},{"issue":"6374","key":"yoi200078r17","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1126\/science.aan6877","article-title":"The nature of nurture: effects of parental genotypes.","volume":"359","author":"Kong","year":"2018","journal-title":"Science"},{"key":"yoi200078r18","doi-asserted-by":"publisher","first-page":"i1224","DOI":"10.1136\/bmj.i1224","article-title":"Can genetic evidence help us understand why height and weight relate to social position?","volume":"352","author":"Davey Smith","year":"2016","journal-title":"BMJ"},{"key":"yoi200078r19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7554\/eLife.49962","article-title":"Can education be personalised using pupils\u2019 genetic data?","volume":"9","author":"Morris","year":"2020","journal-title":"Elife"},{"issue":"R2","key":"yoi200078r20","doi-asserted-by":"publisher","first-page":"R133","DOI":"10.1093\/hmg\/ddz187","article-title":"Towards clinical utility of polygenic risk scores.","volume":"28","author":"Lambert","year":"2019","journal-title":"Hum Mol Genet"},{"issue":"18","key":"yoi200078r21","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1001\/jama.2019.3893","article-title":"What are polygenic scores and why are they important?","volume":"321","author":"Sugrue","year":"2019","journal-title":"JAMA"},{"issue":"1","key":"yoi200078r22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1146\/annurev-statistics-010814-020148","article-title":"Risk and uncertainty communication.","volume":"4","author":"Spiegelhalter","year":"2017","journal-title":"Annu Rev Stat Appl"},{"issue":"9","key":"yoi200078r23","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/s41576-018-0018-x","article-title":"The personal and clinical utility of polygenic risk scores.","volume":"19","author":"Torkamani","year":"2018","journal-title":"Nat Rev Genet"},{"issue":"16","key":"yoi200078r24","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.jacc.2018.07.079","article-title":"Genomic risk prediction of coronary artery disease in 480,000 adults: implications for primary prevention.","volume":"72","author":"Inouye","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"yoi200078r25","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw302","article-title":"Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers.","volume":"109","author":"Kuchenbaecker","year":"2017","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"yoi200078r26","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1186\/s12885-019-5783-1","article-title":"Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification.","volume":"19","author":"L\u00e4ll","year":"2019","journal-title":"BMC Cancer"},{"issue":"8","key":"yoi200078r27","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1038\/s41436-018-0406-9","article-title":"BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors.","volume":"21","author":"Lee","year":"2019","journal-title":"Genet Med"},{"issue":"7","key":"yoi200078r28","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1177\/1403494811399956","article-title":"Introduction to Danish (nationwide) registers on health and social issues: structure, access, legislation, and archiving.","volume":"39","author":"Thygesen","year":"2011","journal-title":"Scand J Public Health"},{"issue":"1","key":"yoi200078r29","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/mp.2017.196","article-title":"The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders.","volume":"23","author":"Pedersen","year":"2018","journal-title":"Mol Psychiatry"},{"issue":"7","key":"yoi200078r30","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish Civil Registration System.","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand J Public Health"},{"issue":"7","key":"yoi200078r31","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1177\/1403494810395825","article-title":"The Danish Psychiatric Central Research Register.","volume":"39","author":"Mors","year":"2011","journal-title":"Scand J Public Health"},{"issue":"8","key":"yoi200078r32","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/S0924-9338(99)80685-3","article-title":"Validity of diagnoses and other clinical register data in patients with affective disorder.","volume":"13","author":"Kessing","year":"1998","journal-title":"Eur Psychiatry"},{"key":"yoi200078r33","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1745-0179-5-4","article-title":"Validity of the diagnosis of a single depressive episode in a case register.","volume":"5","author":"Bock","year":"2009","journal-title":"Clin Pract Epidemiol Ment Health"},{"issue":"7","key":"yoi200078r34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1177\/1403494811408483","article-title":"Danish registers on personal labour market affiliation.","volume":"39","author":"Petersson","year":"2011","journal-title":"Scand J Public Health"},{"issue":"4","key":"yoi200078r35","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1007\/s10545-007-0631-x","article-title":"Storage policies and use of the Danish Newborn Screening Biobank.","volume":"30","author":"N\u00f8rgaard-Pedersen","year":"2007","journal-title":"J Inherit Metab Dis"},{"issue":"11","key":"yoi200078r36","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/s41380-018-0296-x","article-title":"Response to \u201cEthical concerns regarding Danish genetic research\u201d.","volume":"24","author":"Mortensen","year":"2019","journal-title":"Mol Psychiatry"},{"issue":"4","key":"yoi200078r37","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1198\/004017002188618509","article-title":"Robust estimates of location and dispersion for high-dimensional datasets.","volume":"44","author":"Maronna","year":"2002","journal-title":"Technometrics"},{"issue":"16","key":"yoi200078r38","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1093\/bioinformatics\/bty185","article-title":"Efficient analysis of large-scale genome-wide data with two R packages: bigstatsr and bigsnpr.","volume":"34","author":"Priv\u00e9","year":"2018","journal-title":"Bioinformatics"},{"issue":"1","key":"yoi200078r39","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41588-018-0269-7","article-title":"Discovery of the first genome-wide significant risk loci for attention deficit\/hyperactivity disorder.","volume":"51","author":"Demontis","year":"2019","journal-title":"Nat Genet"},{"issue":"3","key":"yoi200078r40","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/s41588-019-0344-8","article-title":"Identification of common genetic risk variants for autism spectrum disorder.","volume":"51","author":"Grove","year":"2019","journal-title":"Nat Genet"},{"issue":"5","key":"yoi200078r41","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1001\/jamapsychiatry.2018.4166","article-title":"Association of polygenic liabilities for major depression, bipolar disorder, and schizophrenia with risk for depression in the Danish population.","volume":"76","author":"Musliner","year":"2019","journal-title":"JAMA Psychiatry"},{"issue":"4","key":"yoi200078r42","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ajhg.2015.09.001","article-title":"Modeling linkage disequilibrium increases accuracy of polygenic risk scores.","volume":"97","author":"Vilhj\u00e1lmsson","year":"2015","journal-title":"Am J Hum Genet"},{"issue":"7","key":"yoi200078r43","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1001\/jamapsychiatry.2015.0346","article-title":"Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: a danish population-based study and meta-analysis.","volume":"72","author":"Agerbo","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"7","key":"yoi200078r44","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1136\/jech.2004.025288","article-title":"Effect of psychiatric illness and labour market status on suicide: a healthy worker effect?","volume":"59","author":"Agerbo","year":"2005","journal-title":"J Epidemiol Community Health"},{"issue":"1","key":"yoi200078r45","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1001\/archpsyc.61.1.28","article-title":"Marital and labor market status in the long run in schizophrenia.","volume":"61","author":"Agerbo","year":"2004","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"yoi200078r46","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2753\/IMH0020-7411390203","article-title":"Unemployment and mental disorders.","volume":"39","author":"Eriksson","year":"2014","journal-title":"International Journal of Mental Health"},{"issue":"8","key":"yoi200078r47","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1016\/j.csda.2006.12.028","article-title":"Computational methods for case-cohort studies.","volume":"51","author":"Langholz","year":"2007","journal-title":"Comput Stat Data Anal"},{"issue":"1","key":"yoi200078r48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1023\/A:1009661900674","article-title":"Exposure stratified case-cohort designs.","volume":"6","author":"Borgan","year":"2000","journal-title":"Lifetime Data Anal"},{"issue":"5","key":"yoi200078r49","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1214\/aos\/1176324322","article-title":"Methods for the analysis of sampled cohort data in the Cox proportional hazards model.","volume":"23","author":"Borgan","year":"1995","journal-title":"Ann Stat"},{"issue":"4","key":"yoi200078r50","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/s41588-019-0379-x","article-title":"Clinical use of current polygenic risk scores may exacerbate health disparities.","volume":"51","author":"Martin","year":"2019","journal-title":"Nat Genet"},{"issue":"13","key":"yoi200078r51","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1017\/S0033291715000744","article-title":"Parental history of psychiatric diagnoses and unipolar depression: a Danish National Register-based cohort study.","volume":"45","author":"Musliner","year":"2015","journal-title":"Psychol Med"},{"issue":"2","key":"yoi200078r52","first-page":"563","article-title":"Approximating the tetrachoric correlation coefficient.","volume":"40","author":"Edwards","year":"1984","journal-title":"Biometrics"},{"issue":"11","key":"yoi200078r53","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.14401","article-title":"Association of childhood exposure to nitrogen dioxide and polygenic risk score for schizophrenia with the risk of developing schizophrenia.","volume":"2","author":"Horsdal","year":"2019","journal-title":"JAMA Netw Open"},{"issue":"7","key":"yoi200078r54","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1111\/add.v115.7","article-title":"Genetic liability to ADHD and substance use disorders in individuals with ADHD.","volume":"115","author":"Wimberley","year":"2020","journal-title":"Addiction"},{"issue":"7","key":"yoi200078r55","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrg.2016.27","article-title":"Developing and evaluating polygenic risk prediction models for stratified disease prevention.","volume":"17","author":"Chatterjee","year":"2016","journal-title":"Nat Rev Genet"},{"issue":"2","key":"yoi200078r56","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.biopsych.2018.12.015","article-title":"Predicting polygenic risk of psychiatric disorders.","volume":"86","author":"Martin","year":"2019","journal-title":"Biol Psychiatry"},{"key":"yoi200078r57","article-title":"Could polygenic risk scores be useful in psychiatry? a review.","author":"Murray","year":"2020","journal-title":"JAMA Psychiatry"},{"issue":"11","key":"yoi200078r58","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1016\/j.biopsych.2018.04.007","article-title":"Polygenic risk scores: what are they good for?","volume":"83","author":"Zheutlin","year":"2018","journal-title":"Biol Psychiatry"},{"issue":"1","key":"yoi200078r59","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13010-019-0073-8","article-title":"Potential use of clinical polygenic risk scores in psychiatry - ethical implications and communicating high polygenic risk.","volume":"14","author":"Palk","year":"2019","journal-title":"Philos Ethics Humanit Med"},{"key":"yoi200078r60","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.copsyc.2018.09.002","article-title":"Polygenic risk scoring and prediction of mental health outcomes.","volume":"27","author":"Anderson","year":"2019","journal-title":"Curr Opin Psychol"},{"key":"yoi200078r61","article-title":"From basic science to clinical application of polygenic risk scores: a primer.","author":"Wray","year":"2020","journal-title":"JAMA Psychiatry"},{"issue":"9","key":"yoi200078r62","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/ejhg.2009.177","article-title":"Sporadic cases are the norm for complex disease.","volume":"18","author":"Yang","year":"2010","journal-title":"Eur J Hum Genet"},{"issue":"2","key":"yoi200078r63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000864","article-title":"The genetic interpretation of area under the ROC curve in genomic profiling.","volume":"6","author":"Wray","year":"2010","journal-title":"PLoS Genet"},{"issue":"1","key":"yoi200078r64","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ajhg.2017.06.005","article-title":"10 Years of GWAS discovery: biology, function, and translation.","volume":"101","author":"Visscher","year":"2017","journal-title":"Am J Hum Genet"},{"key":"yoi200078r65","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyz274","article-title":"Reflection on modern methods: revisiting the area under the ROC Curve.","author":"Janssens","year":"2020","journal-title":"Int J Epidemiol"},{"issue":"6","key":"yoi200078r66","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/acps.2019.139.issue-6","article-title":"Incidence of medically treated depression in Denmark among individuals 15-44 years old: a comprehensive overview based on population registers.","volume":"139","author":"Musliner","year":"2019","journal-title":"Acta Psychiatr Scand"},{"issue":"7","key":"yoi200078r67","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/mp.2015.130","article-title":"High loading of polygenic risk in cases with chronic schizophrenia.","volume":"21","author":"Meier","year":"2016","journal-title":"Mol Psychiatry"},{"issue":"10","key":"yoi200078r68","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/jcpp.12295","article-title":"Research review: polygenic methods and their application to psychiatric traits.","volume":"55","author":"Wray","year":"2014","journal-title":"J Child Psychol Psychiatry"},{"issue":"7","key":"yoi200078r69","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1176\/appi.ajp.2010.10030465","article-title":"Genome-wide association studies: does only size matter?","volume":"167","author":"Schwartz","year":"2010","journal-title":"Am J Psychiatry"},{"issue":"9","key":"yoi200078r70","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1038\/s41588-018-0213-x","article-title":"Genetic risks and clinical rewards.","volume":"50","author":"Schork","year":"2018","journal-title":"Nat Genet"},{"issue":"4","key":"yoi200078r71","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1534\/genetics.119.301859","article-title":"Complex trait prediction from genome data: contrasting EBV in livestock to PRS in humans: genomic prediction.","volume":"211","author":"Wray","year":"2019","journal-title":"Genetics"}],"container-title":["JAMA Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/articlepdf\/2774873\/jamapsychiatry_agerbo_2021_oi_200078_1616513419.80912.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T19:55:10Z","timestamp":1617825310000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2774873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapsychiatry.2020.4172","relation":{},"ISSN":["2168-622X"],"issn-type":[{"value":"2168-622X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4,1]]}}}