{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:50:03Z","timestamp":1792464603897,"version":"4.5.0"},"reference-count":49,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2022,6,1]]},"DOI":"10.1001\/jamapsychiatry.2022.0696","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T11:01:46Z","timestamp":1650452506000},"page":"528","source":"Crossref","is-referenced-by-count":77,"title":["Efficacy of Augmentation of Cognitive Behavioral Therapy With Transcranial Direct Current Stimulation for Depression"],"prefix":"10.1001","volume":"79","author":[{"given":"Sabine","family":"Aust","sequence":"first","affiliation":[{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Department of Psychiatry, Campus Benjamin Franklin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Lotta","family":"Brakemeier","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapy, Universit\u00e4t Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Spies","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Department of Psychiatry, Campus Benjamin Franklin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lucia","family":"Herrera-Melendez","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Department of Psychiatry, Campus Benjamin Franklin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapy, Universit\u00e4t Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fallgatter","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Psychiatrie und Psychotherapie, Neurophysiologie & Interventionelle Neuropsychiatrie, T\u00fcbingen Center for Mental Health, Universit\u00e4tsklinikum T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Plewnia","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Psychiatrie und Psychotherapie, Neurophysiologie & Interventionelle Neuropsychiatrie, T\u00fcbingen Center for Mental Health, Universit\u00e4tsklinikum T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah V.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Psychiatrie und Psychotherapie, Neurophysiologie & Interventionelle Neuropsychiatrie, T\u00fcbingen Center for Mental Health, Universit\u00e4tsklinikum T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Dechantsreiter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Strau\u00df","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Mauche","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Normann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine & Center for Basics in NeuroModulation, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Frase","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine & Center for Basics in NeuroModulation, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Deuschle","sequence":"additional","affiliation":[{"name":"Central Institute for Mental Health, University of Heidelberg\/Medical Faculty Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"B\u00f6hringer","sequence":"additional","affiliation":[{"name":"Central Institute for Mental Health, University of Heidelberg\/Medical Faculty Mannheim, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Padberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Bajbouj","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Department of Psychiatry, Campus Benjamin Franklin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"10161","key":"yoi220019r1","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression.","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"yoi220019r2","doi-asserted-by":"publisher","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder.","volume":"2","author":"Otte","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"7","key":"yoi220019r3","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1001\/jamapsychiatry.2020.0164","article-title":"Psychotherapy for depression across different age groups: a systematic review and meta-analysis.","volume":"77","author":"Cuijpers","year":"2020","journal-title":"JAMA Psychiatry"},{"issue":"11","key":"yoi220019r7","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.","volume":"163","author":"Rush","year":"2006","journal-title":"Am J Psychiatry"},{"issue":"3","key":"yoi220019r8","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/acps.v144.3","article-title":"The effects of psychotherapies for depression on response, remission, reliable change, and deterioration: a meta-analysis.","volume":"144","author":"Cuijpers","year":"2021","journal-title":"Acta Psychiatr Scand"},{"issue":"7","key":"yoi220019r9","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S2215-0366(16)30065-7","article-title":"Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study.","volume":"3","author":"Carhart-Harris","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"yoi220019r10","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1007\/s00406-014-0540-6","article-title":"A perfect match: noninvasive brain stimulation and psychotherapy.","volume":"264","author":"Bajbouj","year":"2014","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"yoi220019r11","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.pnpbp.2018.10.006","article-title":"The dynamic duo: combining noninvasive brain stimulation with cognitive interventions.","volume":"89","author":"Sathappan","year":"2019","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"yoi220019r12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.expneurol.2009.03.038","article-title":"Treatment of depression with transcranial direct current stimulation (tDCS): a review.","volume":"219","author":"Nitsche","year":"2009","journal-title":"Exp Neurol"},{"issue":"1","key":"yoi220019r13","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.brs.2013.08.006","article-title":"Transcranial direct current stimulation enhances cognitive control during emotion regulation.","volume":"7","author":"Feeser","year":"2014","journal-title":"Brain Stimul"},{"issue":"7","key":"yoi220019r14","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.biopsych.2012.10.010","article-title":"Amelioration of cognitive control in depression by transcranial direct current stimulation.","volume":"73","author":"Wolkenstein","year":"2013","journal-title":"Biol Psychiatry"},{"key":"yoi220019r15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.neubiorev.2021.08.017","article-title":"Identifying regions in prefrontal cortex related to working memory improvement: a novel meta-analytic method using electric field modeling.","volume":"130","author":"Wischnewski","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"issue":"15","key":"yoi220019r16","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1017\/S0033291720003670","article-title":"Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis.","volume":"50","author":"Begemann","year":"2020","journal-title":"Psychol Med"},{"issue":"2","key":"yoi220019r17","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.brs.2013.12.008","article-title":"Concurrent cognitive control training augments the antidepressant efficacy of tDCS: a pilot study.","volume":"7","author":"Segrave","year":"2014","journal-title":"Brain Stimul"},{"issue":"8","key":"yoi220019r18","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1111\/ner.12807","article-title":"Feasibility of computerized cognitive-behavioral therapy combined with bifrontal transcranial direct current stimulation for treatment of major depression.","volume":"22","author":"Welch","year":"2019","journal-title":"Neuromodulation"},{"key":"yoi220019r19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression.","volume":"23","author":"Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"8","key":"yoi220019r22","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/(ISSN)1097-4679","article-title":"Treatment for chronic depression using Cognitive Behavioral Analysis System of Psychotherapy (CBASP).","volume":"59","author":"McCullough","year":"2003","journal-title":"J Clin Psychol"},{"issue":"8","key":"yoi220019r23","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/s00406-017-0859-x","article-title":"PsychotherapyPlus: augmentation of cognitive behavioral therapy (CBT) with prefrontal transcranial direct current stimulation (tDCS) in major depressive disorder-study design and methodology of a multicenter double-blind randomized placebo-controlled trial.","volume":"268","author":"Bajbouj","year":"2018","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"pt 1","key":"yoi220019r24","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1113\/jphysiol.2005.092429","article-title":"Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex.","volume":"568","author":"Nitsche","year":"2005","journal-title":"J Physiol"},{"issue":"8","key":"yoi220019r26","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s00406-017-0769-y","article-title":"Prefrontal transcranial direct current stimulation (tDCS) as treatment for major depression: study design and methodology of a multicenter triple blind randomized placebo controlled trial (DepressionDC).","volume":"267","author":"Padberg","year":"2017","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"5","key":"yoi220019r27","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.brs.2021.08.005","article-title":"Transcranial direct current stimulation (tDCS) for major depression\u2014interim analysis of cloud supervised technical data from the DepressionDC trial.","volume":"14","author":"Kumpf","year":"2021","journal-title":"Brain Stimul"},{"key":"yoi220019r28","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change.","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br J Psychiatry"},{"issue":"4","key":"yoi220019r30","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1017\/S0033291700026428","article-title":"Anhedonia: a neglected symptom of psychopathology.","volume":"23","author":"Snaith","year":"1993","journal-title":"Psychol Med"},{"issue":"5","key":"yoi220019r32","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.brs.2014.06.006","article-title":"The role of contact media at the skin-electrode interface during transcranial direct current stimulation (tDCS).","volume":"7","author":"Palm","year":"2014","journal-title":"Brain Stimul"},{"issue":"84","key":"yoi220019r33","doi-asserted-by":"publisher","DOI":"10.3791\/50942","article-title":"Assessment of age-related changes in cognitive functions using EmoCogMeter, a novel tablet-computer based approach.","volume":"84","author":"Fuge","year":"2014","journal-title":"J Vis Exp"},{"issue":"8","key":"yoi220019r34","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1017\/S1461145710001690","article-title":"A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation.","volume":"14","author":"Brunoni","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"issue":"6","key":"yoi220019r35","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.brs.2013.06.004","article-title":"State-dependent effects of prefrontal repetitive transcranial magnetic stimulation on emotional working memory.","volume":"6","author":"Weigand","year":"2013","journal-title":"Brain Stimul"},{"issue":"2","key":"yoi220019r36","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.brs.2014.11.006","article-title":"The interaction with task-induced activity is more important than polarization: a tDCS study.","volume":"8","author":"Bortoletto","year":"2015","journal-title":"Brain Stimul"},{"issue":"1","key":"yoi220019r37","doi-asserted-by":"publisher","first-page":"7878","DOI":"10.1038\/s41598-020-64577-1","article-title":"Metacognitive therapy versus cognitive behaviour therapy in adults with major depression: a parallel single-blind randomised trial.","volume":"10","author":"Callesen","year":"2020","journal-title":"Sci Rep"},{"issue":"4","key":"yoi220019r38","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.brs.2021.06.004","article-title":"Depression treatment by tDCS-enhanced cognitive control training: a test of two stimulation intensities.","volume":"14","author":"Sommer","year":"2021","journal-title":"Brain Stimul"},{"issue":"5","key":"yoi220019r39","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1176\/appi.ajp.2019.19090915","article-title":"Distinct symptom-specific treatment targets for circuit-based neuromodulation.","volume":"177","author":"Siddiqi","year":"2020","journal-title":"Am J Psychiatry"},{"issue":"3","key":"yoi220019r40","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.brs.2020.02.027","article-title":"Determination of anodal tDCS duration threshold for reversal of corticospinal excitability: an investigation for induction of counter-regulatory mechanisms.","volume":"13","author":"Hassanzahraee","year":"2020","journal-title":"Brain Stimul"},{"issue":"7","key":"yoi220019r41","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1113\/jphysiol.2012.249730","article-title":"Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans.","volume":"591","author":"Batsikadze","year":"2013","journal-title":"J Physiol"},{"issue":"6","key":"yoi220019r42","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1002\/hbm.v41.6","article-title":"Current intensity- and polarity-specific online and aftereffects of transcranial direct current stimulation: an fMRI study.","volume":"41","author":"Jamil","year":"2020","journal-title":"Hum Brain Mapp"},{"key":"yoi220019r43","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.pnpbp.2014.09.015","article-title":"Transcranial electric stimulation and neurocognitive training in clinically depressed patients: a pilot study of the effects on rumination.","volume":"57","author":"Vanderhasselt","year":"2015","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"5","key":"yoi220019r44","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/j.brs.2020.07.006","article-title":"Enhancing cognitive control training with transcranial direct current stimulation: a systematic parameter study.","volume":"13","author":"Weller","year":"2020","journal-title":"Brain Stimul"},{"issue":"3","key":"yoi220019r45","doi-asserted-by":"publisher","first-page":"e121","DOI":"10.1016\/j.clinph.2019.12.300","article-title":"Reduced fields show up in schizophrenia and major depression\u2014a prefrontal tDCS simulation study.","volume":"131","author":"Mizutani-Tiebel","year":"2020","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"yoi220019r46","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1001\/2013.jamapsychiatry.32","article-title":"The sertraline vs electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial.","volume":"70","author":"Brunoni","year":"2013","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"yoi220019r47","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.brs.2018.12.977","article-title":"Sham tDCS: a hidden source of variability? reflections for further blinded, controlled trials.","volume":"12","author":"Fonteneau","year":"2019","journal-title":"Brain Stimul"},{"issue":"1","key":"yoi220019r48","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.brs.2017.10.011","article-title":"International randomized-controlled trial of transcranial direct current stimulation in depression.","volume":"11","author":"Loo","year":"2018","journal-title":"Brain Stimul"},{"key":"yoi220019r49","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2020.107991","article-title":"Combined transcranial direct current stimulation and psychological interventions: state of the art and promising perspectives for clinical psychology.","volume":"158","author":"Dedoncker","year":"2021","journal-title":"Biol Psychol"},{"key":"yoi220019r20","volume-title":"Cognitive Therapy of Depression","author":"Beck","year":"1979"},{"key":"yoi220019r21","volume-title":"Kognitive Verhaltenstherapie bei Depression","author":"Hautzinger","year":"2013"},{"key":"yoi220019r29","volume-title":"Manual for the Beck Depression Inventory\u2013II","author":"Beck","year":"1996"},{"key":"yoi220019r31","volume-title":"Encyclopedia of Behavioral Medicine","author":"Hooker","year":"2013"},{"key":"yoi220019r4","unstructured":"American Psychological Association. Clinical practice guideline for the treatment of depression across three age cohorts. 2022. Accessed March 14, 2022. https:\/\/www.apa.org\/depression-guideline"},{"key":"yoi220019r5","unstructured":"National Institute for Health and Care Excellence. Depression. Accessed March 14, 2022. https:\/\/www.nice.org.uk\/guidance\/conditions-and-diseases\/mental-health-and-behavioural-conditions\/depression"},{"key":"yoi220019r6","unstructured":"Nationale Versorgungs Leitlinien. Grundlagen. Accessed March 14, 2022. https:\/\/www.leitlinien.de\/themen\/depression\/2-auflage"},{"key":"yoi220019r25","unstructured":"Spies? J, Bollmann? S, Aust? S, . KVTplus Gruppentherapie: Manual f\u00fcr Studientherapeut:innen der Studie PsychotherapiePlus. Accessed March 7, 2022. https:\/\/refubium.fu-berlin.de\/handle\/fub188\/33912"}],"container-title":["JAMA Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/articlepdf\/2791248\/jamapsychiatry_aust_2022_oi_220019_1654022516.22607.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T11:02:38Z","timestamp":1654081358000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2791248"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapsychiatry.2022.0696","relation":{},"ISSN":["2168-622X"],"issn-type":[{"value":"2168-622X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,1]]}}}