{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:05:08Z","timestamp":1792195508339,"version":"4.4.0"},"reference-count":45,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"Importance<\/jats:title>Prenatal depression is prevalent with negative consequences for both the mother and developing fetus. Brief, effective, and safe interventions to reduce depression during pregnancy are needed.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate depression improvement (symptoms and diagnosis) among pregnant individuals from diverse backgrounds randomized to brief interpersonal psychotherapy (IPT) vs enhanced usual care (EUC).<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>A prospective, evaluator-blinded, randomized clinical trial, the Care Project, was conducted among adult pregnant individuals who reported elevated symptoms during routine obstetric care depression screening in general practice in obstetrics and gynecology (OB\/GYN) clinics. Participants were recruited between July 2017 and August 2021. Repeated measures follow-up occurred across pregnancy from baseline (mean [SD], 16.7 [4.2] gestational weeks) through term. Pregnant participants were randomized to IPT or EUC and included in intent-to-treat analyses.<\/jats:p><\/jats:sec>Interventions<\/jats:title>Treatment comprised an engagement session and 8 active sessions of brief IPT (MOMCare) during pregnancy. EUC included engagement and maternity support services.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Two depression symptom scales, the 20-item Symptom Checklist and the Edinburgh Postnatal Depression Scale, were assessed at baseline and repeatedly across pregnancy. Structured Clinical Interview for DSM-5<\/jats:italic> ascertained major depressive disorder (MDD) at baseline and the end of gestation.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 234 participants, 115 were allocated to IPT (mean [SD] age, 29.7 [5.9] years; 57 [49.6%] enrolled in Medicaid; 42 [36.5%] had current MDD; 106 [92.2%] received intervention) and 119 to EUC (mean [SD] age, 30.1 [5.9] years; 62 [52.1%] enrolled in Medicaid; 44 [37%] had MDD). The 20-item Symptom Checklist scores improved from baseline over gestation for IPT but not EUC (d<\/jats:italic>\u2009=\u20090.57; 95% CI, 0.22-0.91; mean [SD] change for IPT vs EUC: 26.7 [1.14] to 13.6 [1.40] vs 27.1 [1.12] to 23.5 [1.34]). IPT participants more rapidly improved on Edinburgh Postnatal Depression Scale compared with EUC (d<\/jats:italic>\u2009=\u20090.40; 95% CI, 0.06-0.74; mean [SD] change for IPT vs EUC: 11.4 [0.38] to 5.4 [0.57] vs 11.5 [0.37] to 7.6 [0.55]). MDD rate by end of gestation had decreased significantly for IPT participants (7 [6.1%]) vs EUC (31 [26.1%]) (odds ratio, 4.99; 95% CI, 2.08-11.97).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this study, brief IPT significantly reduced prenatal depression symptoms and MDD compared with EUC among pregnant individuals from diverse racial, ethnic, and socioeconomic backgrounds recruited from primary OB\/GYN clinics. As a safe, effective intervention to relieve depression during pregnancy, brief IPT may positively affect mothers\u2019 mental health and the developing fetus.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>ClinicalTrials.gov Identifier: NCT03011801<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jamapsychiatry.2023.0702","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T15:06:56Z","timestamp":1681916816000},"page":"539","source":"Crossref","is-referenced-by-count":62,"title":["Effect of Brief Interpersonal Therapy on Depression During Pregnancy"],"prefix":"10.1001","volume":"80","author":[{"given":"Benjamin L.","family":"Hankin","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Illinois at Urbana-Champaign, Champaign"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine H.","family":"Demers","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Denver, Denver, Colorado"},{"name":"Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella-Marie P.","family":"Hennessey","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Denver, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E. 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