{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:34:42Z","timestamp":1793392482615,"version":"4.5.0"},"reference-count":56,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:sec id=\"ab-yoi230020-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Depression is associated with an increased risk of physical illness, but the most common causes of hospitalization among people with depression are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230020-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association of depression with an array of physical conditions requiring hospital treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230020-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>In this outcomewide prospective multicohort study, primary analysis was based on data from the UK Biobank, a population-based study in the United Kingdom. Analyses were repeated in an independent data set of 2 cohorts in Finland, a population-based study and an occupational cohort. Data analysis was conducted between April and September 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230020-7\">\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>Self-reported depression, recurrent severe major depression, recurrent moderate major depression, and a single major depressive episode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230020-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>A total of 77 common health conditions ascertained from linkage data to national hospital and mortality registries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230020-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analytical sample of UK Biobank participants consisted of 130\u202f652 individuals (71\u202f565 women [54.8%]; 59\u202f087 men [45.2%]; mean [SD] age at baseline, 63.3 [7.8] years). The pooled data from the Finnish replication cohorts included 109\u202f781 participants (82\u202f921 women [78.6%]; 26\u202f860 men [21.4%]; mean [SD] age, 42 [10.8] years). In the main analysis, severe\/moderately severe depression was associated with the incidence of 29 nonoverlapping conditions requiring hospital treatment during a 5-year follow-up. Twenty-five of these associations remained after adjustment for confounders and multiple testing (adjusted hazard ratio [HR] range, 1.52-23.03) and were confirmed in the analysis of the Finnish cohorts. These included sleep disorders (HR, 5.97; 95% CI, 3.27-10.89), diabetes (HR, 5.15; 95% CI, 2.52-10.50), ischemic heart disease (HR, 1.76; 95% CI, 1.36-2.29), chronic obstructive bronchitis (HR, 4.11; 95% CI, 2.56-6.60), bacterial infections (HR, 2.52; 95% CI, 1.99-3.19), back pain (HR, 3.99; 95% CI, 2.96-5.38), and osteoarthritis (HR, 1.80; 95% CI, 1.46-2.20). The highest cumulative incidence was observed for endocrine and related internal organ diseases (245 per 1000 persons with depression; risk difference relative to unaffected individuals: 9.8%), musculoskeletal diseases (91 per 1000 persons; risk difference, 3.7%), and diseases of the circulatory system and blood (86 per 1000 persons; risk difference, 3.9%). The cumulative incidence was lower for hospital-treated mental, behavioral, and neurological disorders (20 in 1000 persons; risk difference, 1.7%). Depression was also associated with disease progression in people with prevalent heart disease or diabetes, and for 12 conditions, there was evidence of a bidirectional relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230020-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>In this study, the most common causes of hospitalization in people with depression were endocrine, musculoskeletal, and vascular diseases, not psychiatric disorders. These findings suggest that depression should be considered as a target for the prevention of physical and mental disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamapsychiatry.2023.0777","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T11:14:11Z","timestamp":1683112451000},"page":"690","source":"Crossref","is-referenced-by-count":116,"title":["Association Between Depression and Physical Conditions Requiring Hospitalization"],"prefix":"10.1001","volume":"80","author":[{"given":"Philipp","family":"Frank","sequence":"first","affiliation":[{"name":"Research Department of Epidemiology and Public Health, University College London, London, United Kingdom"},{"name":"UCL Brain Sciences, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. David","family":"Batty","sequence":"additional","affiliation":[{"name":"Research Department of Epidemiology and Public Health, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Pentti","sequence":"additional","affiliation":[{"name":"Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland"},{"name":"Finnish Institute of Occupational Health, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Jokela","sequence":"additional","affiliation":[{"name":"Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Poole","sequence":"additional","affiliation":[{"name":"School of Psychology, University of Surrey, Guildford, Surrey, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Ervasti","sequence":"additional","affiliation":[{"name":"Finnish Institute of Occupational Health, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Vahtera","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glyn","family":"Lewis","sequence":"additional","affiliation":[{"name":"UCL Brain Sciences, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Steptoe","sequence":"additional","affiliation":[{"name":"Research Department of Behavioural Science and Health, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kivim\u00e4ki","sequence":"additional","affiliation":[{"name":"Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland"},{"name":"Finnish Institute of Occupational Health, Helsinki, Finland"},{"name":"UCL Brain Sciences, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"6","key":"yoi230020r1","doi-asserted-by":"publisher","first-page":"e190337","DOI":"10.1001\/jamapediatrics.2019.0337","article-title":"Diseases, injuries, and risk factors in child and adolescent health, 1990 to 2017: findings from the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study.","volume":"173","author":"Reiner","year":"2019","journal-title":"JAMA Pediatr"},{"issue":"10100","key":"yoi230020r2","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.","volume":"390","author":"Vos","year":"2017","journal-title":"Lancet"},{"issue":"4","key":"yoi230020r3","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1097\/PSY.0000000000000174","article-title":"Systematic review and individual patient data meta-analysis of sex differences in depression and prognosis in persons with myocardial infarction: a MINDMAPS study.","volume":"77","author":"Doyle","year":"2015","journal-title":"Psychosom Med"},{"issue":"8","key":"yoi230020r4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014596","article-title":"Prevalence of depression in myocardial infarction: a PRISMA-compliant meta-analysis.","volume":"98","author":"Feng","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"yoi230020r5","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00592-019-01295-9","article-title":"The prevalence of comorbid depression in patients with type 2 diabetes: an updated systematic review and meta-analysis on huge number of observational studies.","volume":"56","author":"Khaledi","year":"2019","journal-title":"Acta Diabetol"},{"issue":"4","key":"yoi230020r6","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1212\/WNL.0000000000002898","article-title":"Detecting depression in Parkinson disease: a systematic review and meta-analysis.","volume":"87","author":"Goodarzi","year":"2016","journal-title":"Neurology"},{"issue":"1","key":"yoi230020r7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1192\/bjp.bp.111.107664","article-title":"Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis.","volume":"202","author":"Ayerbe","year":"2013","journal-title":"Br J Psychiatry"},{"key":"yoi230020r8","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.genhosppsych.2017.04.001","article-title":"Prevalence and predictors of post-stroke mood disorders: a meta-analysis and meta-regression of depression, anxiety and adjustment disorder.","volume":"47","author":"Mitchell","year":"2017","journal-title":"Gen Hosp Psychiatry"},{"issue":"2","key":"yoi230020r9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/S1470-2045(11)70002-X","article-title":"Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies.","volume":"12","author":"Mitchell","year":"2011","journal-title":"Lancet Oncol"},{"issue":"2","key":"yoi230020r10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/pon.v23.2","article-title":"Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments.","volume":"23","author":"Krebber","year":"2014","journal-title":"Psychooncology"},{"issue":"2","key":"yoi230020r11","doi-asserted-by":"publisher","first-page":"189","DOI":"10.2174\/1567205012666150204124310","article-title":"The prevalence of depression in Alzheimer\u2019s disease: a systematic review and meta-analysis.","volume":"12","author":"Chi","year":"2015","journal-title":"Curr Alzheimer Res"},{"key":"yoi230020r12","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.pnpbp.2018.05.025","article-title":"Association between depression and the subsequent risk of Parkinson\u2019s disease: a meta-analysis.","volume":"86","author":"Wang","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"7","key":"yoi230020r13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132424","article-title":"The relationship between depression and asthma: a meta-analysis of prospective studies.","volume":"10","author":"Gao","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"yoi230020r14","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.2337\/dc11-2055","article-title":"Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies.","volume":"35","author":"Pan","year":"2012","journal-title":"Diabetes Care"},{"issue":"12","key":"yoi230020r15","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.2337\/dc08-0985","article-title":"Depression and type 2 diabetes over the lifespan: a meta-analysis.","volume":"31","author":"Mezuk","year":"2008","journal-title":"Diabetes Care"},{"issue":"11","key":"yoi230020r16","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1001\/jama.2011.1282","article-title":"Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review.","volume":"306","author":"Pan","year":"2011","journal-title":"JAMA"},{"key":"yoi230020r17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4933","article-title":"Association between psychological distress and mortality: individual participant pooled analysis of 10 prospective cohort studies.","volume":"345","author":"Russ","year":"2012","journal-title":"BMJ"},{"issue":"23","key":"yoi230020r18","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1093\/eurheartj\/ehl338","article-title":"Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies.","volume":"27","author":"Nicholson","year":"2006","journal-title":"Eur Heart J"},{"issue":"15","key":"yoi230020r19","doi-asserted-by":"publisher","first-page":"e1316","DOI":"10.1212\/WNL.0000000000005302","article-title":"Psychiatric comorbidity is associated with disability progression in multiple sclerosis.","volume":"90","author":"McKay","year":"2018","journal-title":"Neurology"},{"issue":"21","key":"yoi230020r20","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1093\/eurheartj\/eht462","article-title":"Depression and cardiovascular disease: a clinical review.","volume":"35","author":"Hare","year":"2014","journal-title":"Eur Heart J"},{"issue":"6","key":"yoi230020r21","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S2213-8587(15)00134-5","article-title":"The link between depression and diabetes: the search for shared mechanisms.","volume":"3","author":"Moulton","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"yoi230020r22","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ijcard.2005.05.053","article-title":"Prediction of depressive disorder following myocardial infarction data from the Myocardial Infarction and Depression-Intervention Trial (MIND-IT).","volume":"109","author":"van Melle","year":"2006","journal-title":"Int J Cardiol"},{"issue":"10","key":"yoi230020r23","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1001\/jamapsychiatry.2016.1932","article-title":"Incidence of depression after stroke, and associated risk factors and mortality outcomes, in a large cohort of Danish patients.","volume":"73","author":"J\u00f8rgensen","year":"2016","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"yoi230020r24","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.diabres.2012.11.022","article-title":"Diabetes mellitus as a risk factor for depression: a meta-analysis of longitudinal studies.","volume":"99","author":"Rotella","year":"2013","journal-title":"Diabetes Res Clin Pract"},{"issue":"2","key":"yoi230020r25","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1001\/jamapsychiatry.2015.2688","article-title":"Association of mental disorders with subsequent chronic physical conditions: world mental health surveys from 17 countries.","volume":"73","author":"Scott","year":"2016","journal-title":"JAMA Psychiatry"},{"issue":"11","key":"yoi230020r26","doi-asserted-by":"publisher","first-page":"6736","DOI":"10.1038\/s41380-021-01170-6","article-title":"Disease trajectories and mortality among individuals diagnosed with depression: a community-based cohort study in UK Biobank.","volume":"26","author":"Han","year":"2021","journal-title":"Mol Psychiatry"},{"issue":"5","key":"yoi230020r27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.genhosppsych.2008.05.001","article-title":"Major depression as a risk factor for chronic disease incidence: longitudinal analyses in a general population cohort.","volume":"30","author":"Patten","year":"2008","journal-title":"Gen Hosp Psychiatry"},{"issue":"18","key":"yoi230020r28","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1056\/NEJMoa1915784","article-title":"Association between mental disorders and subsequent medical conditions.","volume":"382","author":"Momen","year":"2020","journal-title":"N Engl J Med"},{"issue":"7","key":"yoi230020r29","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1038\/s41380-019-0486-1","article-title":"Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank.","volume":"25","author":"Mulugeta","year":"2020","journal-title":"Mol Psychiatry"},{"issue":"11","key":"yoi230020r31","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1023\/A:1020016922473","article-title":"Non-response and related factors in a nation-wide health survey.","volume":"17","author":"Korkeila","year":"2001","journal-title":"Eur J Epidemiol"},{"issue":"5","key":"yoi230020r32","doi-asserted-by":"publisher","first-page":"874","DOI":"10.2105\/AJPH.2005.078691","article-title":"Socioeconomic position, co-occurrence of behavior-related risk factors, and coronary heart disease: the Finnish Public Sector study.","volume":"97","author":"Kivim\u00e4ki","year":"2007","journal-title":"Am J Public Health"},{"issue":"11","key":"yoi230020r33","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1007\/s11606-007-0333-y","article-title":"Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): a diagnostic meta-analysis.","volume":"22","author":"Gilbody","year":"2007","journal-title":"J Gen Intern Med"},{"issue":"9","key":"yoi230020r34","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure.","volume":"16","author":"Kroenke","year":"2001","journal-title":"J Gen Intern Med"},{"issue":"11","key":"yoi230020r35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075362","article-title":"Prevalence and characteristics of probable major depression and bipolar disorder within UK Biobank: cross-sectional study of 172,751 participants.","volume":"8","author":"Smith","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"yoi230020r37","doi-asserted-by":"publisher","first-page":"e396","DOI":"10.1016\/S2468-2667(21)00066-9","article-title":"Modifications to residential neighbourhood characteristics and risk of 79 common health conditions: a prospective cohort study.","volume":"6","author":"Kivim\u00e4ki","year":"2021","journal-title":"Lancet Public Health"},{"issue":"3","key":"yoi230020r38","doi-asserted-by":"publisher","first-page":"e140","DOI":"10.1016\/S2468-2667(19)30248-8","article-title":"Association between socioeconomic status and the development of mental and physical health conditions in adulthood: a multi-cohort study.","volume":"5","author":"Kivim\u00e4ki","year":"2020","journal-title":"Lancet Public Health"},{"issue":"2","key":"yoi230020r39","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables.","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc Series B Stat Methodol"},{"issue":"8","key":"yoi230020r40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020124","article-title":"Why most published research findings are false.","volume":"2","author":"Ioannidis","year":"2005","journal-title":"PLoS Med"},{"issue":"4","key":"yoi230020r41","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/sim.v30.4","article-title":"Multiple imputation using chained equations: issues and guidance for practice.","volume":"30","author":"White","year":"2011","journal-title":"Stat Med"},{"issue":"3","key":"yoi230020r42","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies.","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"yoi230020r43","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ajp.2015.12.008","article-title":"Is there a bi-directional relationship between depression and obesity among adult men and women? systematic review and bias-adjusted meta analysis.","volume":"21","author":"Mannan","year":"2016","journal-title":"Asian J Psychiatr"},{"issue":"1","key":"yoi230020r44","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0749-3797(02)00439-7","article-title":"Depression as a predictor for coronary heart disease: a review and meta-analysis.","volume":"23","author":"Rugulies","year":"2002","journal-title":"Am J Prev Med"},{"issue":"7","key":"yoi230020r45","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1007\/s00125-020-05131-6","article-title":"Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study.","volume":"63","author":"Tang","year":"2020","journal-title":"Diabetologia"},{"issue":"1","key":"yoi230020r46","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41572-020-0200-2","article-title":"Comorbid depression in medical diseases.","volume":"6","author":"Gold","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"yoi230020r47","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012346.pub2","article-title":"Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease.","volume":"12","author":"Pollok","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"yoi230020r48","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1111\/add.v112.6","article-title":"The relationship between different dimensions of alcohol use and the burden of disease: an update.","volume":"112","author":"Rehm","year":"2017","journal-title":"Addiction"},{"issue":"4","key":"yoi230020r49","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1111\/jcmm.2019.23.issue-4","article-title":"Depression in sleep disturbance: a review on a bidirectional relationship, mechanisms and treatment.","volume":"23","author":"Fang","year":"2019","journal-title":"J Cell Mol Med"},{"key":"yoi230020r50","first-page":"16","article-title":"Common pathways of depression and pain.","volume":"65","author":"Delgado","year":"2004","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"yoi230020r51","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.biopsych.2020.01.014","article-title":"Depression heterogeneity and its biological underpinnings: toward immunometabolic depression.","volume":"88","author":"Milaneschi","year":"2020","journal-title":"Biol Psychiatry"},{"issue":"6","key":"yoi230020r52","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1176\/appi.ajp.2020.20060947","article-title":"Elevated C-reactive protein in patients with depression, independent of genetic, health, and psychosocial factors: results from the UK Biobank.","volume":"178","author":"Pitharouli","year":"2021","journal-title":"Am J Psychiatry"},{"issue":"1","key":"yoi230020r53","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41380-018-0017-5","article-title":"Depression and obesity: evidence of shared biological mechanisms.","volume":"24","author":"Milaneschi","year":"2019","journal-title":"Mol Psychiatry"},{"issue":"12","key":"yoi230020r54","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1176\/appi.ajp.2021.20121776","article-title":"Association between systemic inflammation and individual symptoms of depression: a pooled analysis of 15 population-based cohort studies.","volume":"178","author":"Frank","year":"2021","journal-title":"Am J Psychiatry"},{"key":"yoi230020r55","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.bbi.2022.07.009","article-title":"Overweight, obesity, and individual symptoms of depression: a multicohort study with replication in UK Biobank.","volume":"105","author":"Frank","year":"2022","journal-title":"Brain Behav Immun"},{"issue":"7","key":"yoi230020r56","first-page":"458","article-title":"An epidemiologic study of mortality within a cohort of rubber workers, 1964-72.","volume":"16","author":"McMichael","year":"1974","journal-title":"J Occup Med"},{"key":"yoi230020r30","unstructured":"Collins? R, UK Biobank. UK Biobank: protocol for a large-scale prospective epidemiological resource. Amended March 21, 2007. https:\/\/www.ukbiobank.ac.uk\/media\/gnkeyh2q\/study-rationale.pdf"},{"key":"yoi230020r36","unstructured":"UK Biobank. Field descriptions and derivation for variables related to bipolar disorder, major depression status and neuroticism score. Accessed January 1, 2022. https:\/\/biobank.ndph.ox.ac.uk\/showcase\/ukb\/docs\/MentalStatesDerivation.pdf"}],"container-title":["JAMA Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/articlepdf\/2804269\/jamapsychiatry_frank_2023_oi_230020_1687981929.61045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T14:34:00Z","timestamp":1729348440000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2804269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapsychiatry.2023.0777","relation":{},"ISSN":["2168-622X"],"issn-type":[{"value":"2168-622X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,1]]}}}