{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:16:54Z","timestamp":1792333014909,"version":"4.4.0"},"reference-count":71,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:sec id=\"ab-yoi230021-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Physical health and chronic medical comorbidities are underestimated, inadequately treated, and often overlooked in psychiatry. A multiorgan, systemwide characterization of brain and body health in neuropsychiatric disorders may enable systematic evaluation of brain-body health status in patients and potentially identify new therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230021-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the health status of the brain and 7 body systems across common neuropsychiatric disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230021-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>Brain imaging phenotypes, physiological measures, and blood- and urine-based markers were harmonized across multiple population-based neuroimaging biobanks in the US, UK, and Australia, including UK Biobank; Australian Schizophrenia Research Bank; Australian Imaging, Biomarkers, and Lifestyle Flagship Study of Ageing; Alzheimer\u2019s Disease Neuroimaging Initiative; Prospective Imaging Study of Ageing; Human Connectome Project\u2013Young Adult; and Human Connectome Project\u2013Aging. Cross-sectional data acquired between March 2006 and December 2020 were used to study organ health. Data were analyzed from October 18, 2021, to July 21, 2022. Adults aged 18 to 95 years with a lifetime diagnosis of 1 or more common neuropsychiatric disorders, including schizophrenia, bipolar disorder, depression, generalized anxiety disorder, and a healthy comparison group were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230021-7\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Deviations from normative reference ranges for composite health scores indexing the health and function of the brain and 7 body systems. Secondary outcomes included accuracy of classifying diagnoses (disease vs control) and differentiating between diagnoses (disease vs disease), measured using the area under the receiver operating characteristic curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230021-8\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 85\u202f748 participants with preselected neuropsychiatric disorders (36\u202f324 male) and 87\u202f420 healthy control individuals (40\u202f560 male) included in this study. Body health, especially scores indexing metabolic, hepatic, and immune health, deviated from normative reference ranges for all 4 neuropsychiatric disorders studied. Poor body health was a more pronounced illness manifestation compared to brain changes in schizophrenia (AUC for body\u2009=\u20090.81 [95% CI, 0.79-0.82]; AUC for brain\u2009=\u20090.79 [95% CI, 0.79-0.79]), bipolar disorder (AUC for body\u2009=\u20090.67 [95% CI, 0.67-0.68]; AUC for brain\u2009=\u20090.58 [95% CI, 0.57-0.58]), depression (AUC for body\u2009=\u20090.67 [95% CI, 0.67-0.68]; AUC for brain\u2009=\u20090.58 [95% CI, 0.58-0.58]), and anxiety (AUC for body\u2009=\u20090.63 [95% CI, 0.63-0.63]; AUC for brain\u2009=\u20090.57 [95% CI, 0.57-0.58]). However, brain health enabled more accurate differentiation between distinct neuropsychiatric diagnoses than body health (schizophrenia-other: mean AUC for body\u2009=\u20090.70 [95% CI, 0.70-0.71] and mean AUC for brain\u2009=\u20090.79 [95% CI, 0.79-0.80]; bipolar disorder-other: mean AUC for body\u2009=\u20090.60 [95% CI, 0.59-0.60] and mean AUC for brain\u2009=\u20090.65 [95% CI, 0.65-0.65]; depression-other: mean AUC for body\u2009=\u20090.61 [95% CI, 0.60-0.63] and mean AUC for brain\u2009=\u20090.65 [95% CI, 0.65-0.66]; anxiety-other: mean AUC for body\u2009=\u20090.63 [95% CI, 0.62-0.63] and mean AUC for brain\u2009=\u20090.66 [95% CI, 0.65-0.66).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi230021-9\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>In this cross-sectional study, neuropsychiatric disorders shared a substantial and largely overlapping imprint of poor body health. Routinely monitoring body health and integrated physical and mental health care may help reduce the adverse effect of physical comorbidity in people with mental illness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamapsychiatry.2023.0791","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T11:33:43Z","timestamp":1682508823000},"page":"567","source":"Crossref","is-referenced-by-count":94,"title":["Evaluation of Brain-Body Health in Individuals With Common Neuropsychiatric Disorders"],"prefix":"10.1001","volume":"80","author":[{"given":"Ye Ella","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Melbourne Neuropsychiatry Centre, Melbourne Medical School, the University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Di Biase","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Melbourne Neuropsychiatry Centre, Melbourne Medical School, the University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"Mosley","sequence":"additional","affiliation":[{"name":"Clinical Brain Networks Group, Queensland Institute of Medical Research Berghofer Medical Institute, Brisbane, Queensland, Australia"},{"name":"Queensland Brain Institute, Brisbane, Queensland, Australia"},{"name":"Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation Health and Biosecurity, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle K.","family":"Lupton","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[{"name":"Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation Health and Biosecurity, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Fripp","sequence":"additional","affiliation":[{"name":"Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation Health and Biosecurity, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Breakspear","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry, College of Health, Medicine and Wellbeing, the University of Newcastle, Newcastle, New South Wales, Australia"},{"name":"School of Psychological Sciences, College of Engineering, Science and Environment, the University of Newcastle, Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Cropley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Melbourne Neuropsychiatry Centre, Melbourne Medical School, the University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Zalesky","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Melbourne Neuropsychiatry Centre, Melbourne Medical School, the University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Department of Biomedical Engineering, Faculty of Engineering and Information Technology, the University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"yoi230021r1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/wps.2011.10.issue-1","article-title":"Physical illness in patients with severe mental disorders. 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