{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:25:58Z","timestamp":1792682758750,"version":"4.5.0"},"reference-count":13,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:sec id=\"ab-ybr230003-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Premenstrual disorders are heritable, clinically heterogenous, with a range of affective spectrum comorbidities. It is unclear whether genetic predispositions to affective spectrum disorders or other major psychiatric disorders are associated with symptoms of premenstrual disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ybr230003-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assesss whether symptoms of premenstrual disorders are associated with the genetic liability for major psychiatric disorders, as indexed by polygenic risk scores (PRSs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ybr230003-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>Women from the Norwegian Mother, Father and Child Cohort Study were included in this genetic association study. PRSs were used to determine whether genetic liability for major depression, bipolar disorder, schizophrenia, attention-deficit\/hyperactivity disorder, and autism spectrum disorder were associated with the symptoms of premenstrual disorders, using the PRS for height as a somatic comparator. The sample was recruited across Norway between June 1999 and December 2008, and analyses were performed from July 1 to October 14, 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ybr230003-7\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>The symptoms of premenstrual disorders were assessed at recruitment at week 15 of pregnancy with self-reported severity of depression and irritability before menstruation. Logistic regression was applied to test for the association between the presence of premenstrual disorder symptoms and the PRSs for major psychiatric disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ybr230003-8\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean (SD) age of 56\u202f725 women included in the study was 29.0 (4.6) years. Premenstrual disorder symptoms were present in 12\u202f316 of 56\u202f725 participants (21.7%). The symptoms of premenstrual disorders were associated with the PRSs for major depression (\u03b2\u2009=\u20090.13; 95% CI, 0.11-0.15;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20091.21\u2009\u00d7\u200910\n                      <jats:sup>\u221236<\/jats:sup>\n                      ), bipolar disorder (\u03b2\u2009=\u20090.07; 95% CI, 0.05-0.09;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20091.74\u2009\u00d7\u200910\n                      <jats:sup>\u221211<\/jats:sup>\n                      ), attention deficit\/hyperactivity disorder (\u03b2\u2009=\u20090.07; 95% CI, 0.04-0.09;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20091.58\u2009\u00d7\u200910\n                      <jats:sup>\u22129<\/jats:sup>\n                      ), schizophrenia (\u03b2\u2009=\u20090.11; 95% CI, 0.09-0.13;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20097.61\u2009\u00d7\u200910\n                      <jats:sup>\u221225<\/jats:sup>\n                      ), and autism spectrum disorder (\u03b2\u2009=\u20090.03; 95% CI, 0.01-0.05;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.02) but not with the PRS for height. The findings were confirmed in a subsample of women without a history of psychiatric diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ybr230003-9\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of this genetic association study show that genetic liability for both affective spectrum disorder and major psychiatric disorders was associated with symptoms of premenstrual disorders, indicating that premenstrual disorders have overlapping genetic foundations with major psychiatric disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamapsychiatry.2023.1137","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T12:33:41Z","timestamp":1683722021000},"page":"738","source":"Crossref","is-referenced-by-count":34,"title":["Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders"],"prefix":"10.1001","volume":"80","author":[{"given":"Piotr","family":"Jaholkowski","sequence":"first","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey A.","family":"Shadrin","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jangmo","sequence":"additional","affiliation":[{"name":"Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniia","family":"Frei","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markos","family":"Tesfaye","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Department of Psychiatry, St Paul\u2019s Hospital Millennium Medical College, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy F. L.","family":"Hindley","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit","family":"Haram","sequence":"additional","affiliation":[{"name":"Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway"},{"name":"Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zillur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Athanasiu","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora Refsum","family":"Bakken","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00f8rge","family":"Holen","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Fominykh","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleda","family":"Kutrolli","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravesh","family":"Parekh","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Parker","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn","family":"R\u00f8devand","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Birken\u00e6s","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdjan","family":"Djurovic","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Oslo University Hospital, Oslo, Norway"},{"name":"NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Frei","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav B.","family":"Smeland","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Tesli","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole A.","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"ybr230003r1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ajog.2017.05.045","article-title":"Premenstrual disorders.","volume":"218","author":"Yonkers","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"ybr230003r2","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1176\/appi.ajp.2012.11081302","article-title":"Premenstrual dysphoric disorder: evidence for a new category for DSM-5.","volume":"169","author":"Epperson","year":"2012","journal-title":"Am J Psychiatry"},{"key":"ybr230003r3","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1186\/1471-2458-11-795","article-title":"The interrelation between premenstrual syndrome and major depression: results from a population-based sample.","volume":"11","author":"Forrester-Knauss","year":"2011","journal-title":"BMC Public Health"},{"key":"ybr230003r4","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jpsychires.2019.11.010","article-title":"History of premenstrual syndrome and development of postpartum depression: a systematic review and meta-analysis.","volume":"121","author":"Cao","year":"2020","journal-title":"J Psychiatr Res"},{"issue":"5","key":"ybr230003r5","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/acps.2017.136.issue-5","article-title":"Increased illness burden in women with comorbid bipolar and premenstrual dysphoric disorder: data from 1 099 women from STEP-BD study.","volume":"136","author":"Slyepchenko","year":"2017","journal-title":"Acta Psychiatr Scand"},{"issue":"2","key":"ybr230003r6","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1093\/ije\/dyw029","article-title":"Cohort profile update: the Norwegian Mother and Child Cohort Study (MoBa).","volume":"45","author":"Magnus","year":"2016","journal-title":"Int J Epidemiol"},{"issue":"7","key":"ybr230003r8","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giz082","article-title":"PRSice-2: Polygenic Risk Score software for biobank-scale data.","volume":"8","author":"Choi","year":"2019","journal-title":"Gigascience"},{"issue":"7","key":"ybr230003r9","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1002\/gepi.v44.7","article-title":"A principal component approach to improve association testing with polygenic risk scores.","volume":"44","author":"Coombes","year":"2020","journal-title":"Genet Epidemiol"},{"issue":"1","key":"ybr230003r11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12884-018-1764-7","article-title":"Nausea and vomiting in pregnancy\u2014association with pelvic girdle pain during pregnancy and 4-6 months post-partum.","volume":"18","author":"Chortatos","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"issue":"9","key":"ybr230003r12","first-page":"779","article-title":"A simple method of assessing premenstrual syndrome in large prospective studies.","volume":"52","author":"Bertone-Johnson","year":"2007","journal-title":"J Reprod Med"},{"issue":"1","key":"ybr230003r13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00737-010-0201-3","article-title":"Towards a consensus on diagnostic criteria, measurement and trial design of the premenstrual disorders: the ISPMD Montreal consensus.","volume":"14","author":"O\u2019Brien","year":"2011","journal-title":"Arch Womens Ment Health"},{"key":"ybr230003r7","doi-asserted-by":"crossref","unstructured":"Corfield? EC, Frei? O, Shadrin? AA, . The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1.? bioRxiv. Preprint posted June 26, 2022. Published online January 1, 2022. doi:10.1101\/2022.06.23.496289?","DOI":"10.1101\/2022.06.23.496289"},{"key":"ybr230003r10","unstructured":"Chortatos? A. Nausea and vomiting in pregnancy: effects on maternal diet, health, and birth outcomes. An investigation using the Norwegian Mother and Child Cohort Study. Oslo Centre for Biostatistics and Epidemiiology and Department of Nutrition, University of Oslo. 2016. Accessed March 31, 2022. https:\/\/www.duo.uio.no\/bitstream\/handle\/10852\/53674\/PhD-Chortatos-DUO.pdf?sequence=1"}],"container-title":["JAMA Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/articlepdf\/2804645\/jamapsychiatry_jaholkowski_2023_br_230003_1687981943.33211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T11:08:56Z","timestamp":1688555336000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2804645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapsychiatry.2023.1137","relation":{},"ISSN":["2168-622X"],"issn-type":[{"value":"2168-622X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,1]]}}}