{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:58:11Z","timestamp":1791403091161,"version":"4.3.3"},"reference-count":75,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:sec id=\"ab-yoi230070-4\"><jats:title>Importance<\/jats:title><jats:p>Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen with illness progression, but the mechanisms underlying the specific spatial patterning of these changes is unknown.<\/jats:p><\/jats:sec><jats:sec id=\"ab-yoi230070-5\"><jats:title>Objective<\/jats:title><jats:p>To test the hypothesis that brain network architecture constrains cross-sectional and longitudinal gray matter alterations across different stages of psychotic illness and to identify whether certain brain regions act as putative epicenters from which volume loss spreads.<\/jats:p><\/jats:sec><jats:sec id=\"ab-yoi230070-6\"><jats:title>Design, Settings, and Participants<\/jats:title><jats:p>This case-control study included 534 individuals from 4 cohorts, spanning early and late stages of psychotic illness. Early-stage cohorts included patients with antipsychotic-naive first-episode psychosis (n\u2009=\u200959) and a group of patients receiving medications within 3 years of psychosis onset (n\u2009=\u2009121). Late-stage cohorts comprised 2 independent samples of people with established schizophrenia (n\u2009=\u2009136). Each patient group had a corresponding matched control group (n\u2009=\u2009218). A sample of healthy adults (n\u2009=\u2009356) was used to derive representative structural and functional brain networks for modeling of network-based spreading processes. Longitudinal illness-related and antipsychotic-related gray matter changes over 3 and 12 months were examined using a triple-blind randomized placebo-control magnetic resonance imaging study of the antipsychotic-naive patients. All data were collected between April 29, 2008, and January 15, 2020, and analyses were performed between March 1, 2021, and January 14, 2023.<\/jats:p><\/jats:sec><jats:sec id=\"ab-yoi230070-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Coordinated deformation models were used to estimate the extent of gray matter volume (GMV) change in each of 332 parcellated areas by the volume changes observed in areas to which they were structurally or functionally coupled. To identify putative epicenters of volume loss, a network diffusion model was used to simulate the spread of pathology from different seed regions. Correlations between estimated and empirical spatial patterns of GMV alterations were used to quantify model performance.<\/jats:p><\/jats:sec><jats:sec id=\"ab-yoi230070-8\"><jats:title>Results<\/jats:title><jats:p>Of 534 included individuals, 354 (66.3%) were men, and the mean (SD) age was 28.4 (7.4) years. In both early and late stages of illness, spatial patterns of cross-sectional volume differences between patients and controls were more accurately estimated by coordinated deformation models constrained by structural, rather than functional, network architecture (<jats:italic>r<\/jats:italic> range, &amp;amp;gt;0.46 to &amp;amp;lt;0.57; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.01). The same model also robustly estimated longitudinal volume changes related to illness (<jats:italic>r<\/jats:italic>\u2009\u2265\u20090.52; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001) and antipsychotic exposure (<jats:italic>r<\/jats:italic>\u2009\u2265\u20090.50; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.004). Network diffusion modeling consistently identified, across all 4 data sets, the anterior hippocampus as a putative epicenter of pathological spread in psychosis. Epicenters of longitudinal GMV loss were apparent in posterior cortex early in the illness and shifted to the prefrontal cortex with illness progression.<\/jats:p><\/jats:sec><jats:sec id=\"ab-yoi230070-9\"><jats:title>Conclusion and Relevance<\/jats:title><jats:p>These findings highlight a central role for white matter fibers as conduits for the spread of pathology across different stages of psychotic illness, mirroring findings reported in neurodegenerative conditions. The structural connectome thus represents a fundamental constraint on brain changes in psychosis, regardless of whether these changes are caused by illness or medication. Moreover, the anterior hippocampus represents a putative epicenter of early brain pathology from which dysfunction may spread to affect connected areas.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamapsychiatry.2023.3293","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T15:11:25Z","timestamp":1695222685000},"page":"1246","source":"Crossref","is-referenced-by-count":88,"title":["Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis"],"prefix":"10.1001","volume":"80","author":[{"given":"Sidhant","family":"Chopra","sequence":"first","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia"},{"name":"Monash Biomedical Imaging, Monash University, Clayton, Victoria, Australia"},{"name":"Department of Psychology, Yale University, New Haven, 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