{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:00:56Z","timestamp":1792692056090,"version":"4.5.0"},"reference-count":33,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"Importance<\/jats:title>Major depressive disorder is one of the most common mental disorders among adolescents, entailing severe, long-term psychosocial impairment and a high risk of chronicity. In view of the large number of patients requiring treatment, along with insufficient treatment responses with small effect sizes, innovative adjunctive treatment strategies are urgently needed.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate whether the effect of adolescent psychiatric inpatient treatment as usual for major depressive disorder can be enhanced by simultaneous use of morning bright light therapy.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This was a double-blind, placebo-controlled randomized parallel-group trial with enrollment between March 2018 and November 2020 and follow-up completed in May 2021. The study took place among inpatients at 4 university hospitals for child and adolescent psychiatry across Germany. Of 248 eligible youth aged 12 to 18 years fulfilling ICD-10<\/jats:italic> criteria for major depressive disorder, 227 were randomized to bright light therapy (n\u2009=\u2009116) or placebo red light (n\u2009=\u2009111); 151 participants completed the study.<\/jats:p><\/jats:sec>Interventions<\/jats:title>Up to 20 sessions of either morning bright light therapy with an intensity of 10\u202f000 lux or placebo red light (100 lux) in addition to multimodal inpatient treatment as usual over 4 weeks.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcome was the change in Beck Depression Inventory-II (BDI-II) score from baseline to posttreatment in the intention-to-treat sample.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the 224 patients included in the intention-to-treat analyses (192 girls and 32 boys; mean [SD] age, 15.5 [1.4] years), the mean (SD) BDI-II score at baseline was 37.3 (8.7). BDI-II scores were significantly reduced after 4 weeks (postassessment) by a mean of \u22127.5 (95% CI, \u22129.0 to \u22126.0; Hedges g<\/jats:italic>\u2009=\u20090.71). Bright light therapy had no impact on this change (no significant group\u2009\u00d7\u2009time effect). Loss to follow-up was 31% (n\u2009=\u200969) at 16 weeks and 49% (n\u2009=\u2009110) at 28 weeks. There were 10 serious adverse events throughout the whole trial, which were not considered related to study treatment.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>The findings in this study did not indicate superiority of bright light therapy over placebo red light therapy in a large sample of adolescent inpatients with moderate or severe major depressive disorder. Both groups benefited equally from treatment as usual, showing relevant symptom reduction.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>German Clinical Trials Register: DRKS00013188<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jamapsychiatry.2024.0103","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:11:15Z","timestamp":1710342675000},"page":"655","source":"Crossref","is-referenced-by-count":22,"title":["Bright Light Therapy as Add-On to Inpatient Treatment in Youth With Moderate to Severe Depression"],"prefix":"10.1001","volume":"81","author":[{"given":"Tanja","family":"Legenbauer","sequence":"first","affiliation":[{"name":"LWL University Hospital Hamm for Child and Adolescent Psychiatry, Ruhr-University Bochum, Hamm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inken","family":"Kirschbaum-Lesch","sequence":"additional","affiliation":[{"name":"LWL University Hospital Hamm for Child and Adolescent 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