{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:23:35Z","timestamp":1792614215585,"version":"4.5.0"},"reference-count":63,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:sec id=\"ab-yoi240086-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi240086-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To examine the association between depressive symptoms and amyloid pathology and its dependency on age, sex, education, and\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype in older individuals without dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi240086-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>Cross-sectional analyses were performed using data from the Amyloid Biomarker Study data pooling initiative. Data from 49 research, population-based, and memory clinic studies were pooled and harmonized. The Amyloid Biomarker Study has been collecting data since 2012 and data collection is ongoing. At the time of analysis, 95 centers were included in the Amyloid Biomarker Study. The study included 9746 individuals with normal cognition (NC) and 3023 participants with mild cognitive impairment (MCI) aged between 34 and 100 years for whom data on amyloid biomarkers, presence of depressive symptoms, and age were available. Data were analyzed from December 2022 to February 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi240086-7\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Amyloid-\u03b21-42 levels in cerebrospinal fluid or amyloid positron emission tomography scans were used to determine presence or absence of amyloid pathology. Presence of depressive symptoms was determined on the basis of validated depression rating scale scores, evidence of a current clinical diagnosis of depression, or self-reported depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi240086-8\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In individuals with NC (mean [SD] age, 68.6 [8.9] years; 5664 [58.2%] female; 3002 [34.0%]\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers; 937 [9.6%] had depressive symptoms; 2648 [27.2%] had amyloid pathology), the presence of depressive symptoms was not associated with amyloid pathology (odds ratio [OR], 1.13; 95% CI, 0.90-1.40;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.29). In individuals with MCI (mean [SD] age, 70.2 [8.7] years; 1481 [49.0%] female; 1046 [44.8%]\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers; 824 [27.3%] had depressive symptoms; 1668 [55.8%] had amyloid pathology), the presence of depressive symptoms was associated with a lower likelihood of amyloid pathology (OR, 0.73; 95% CI 0.61-0.89;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001). When considering subgroup effects, in individuals with NC, the presence of depressive symptoms was associated with a higher frequency of amyloid pathology in\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 noncarriers (mean difference, 5.0%; 95% CI 1.0-9.0;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.02) but not in\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers. This was not the case in individuals with MCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-yoi240086-9\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>Depressive symptoms were not consistently associated with a higher frequency of amyloid pathology in participants with NC and were associated with a lower likelihood of amyloid pathology in participants with MCI. These findings were not influenced by age, sex, or education level. Mechanisms other than amyloid accumulation may commonly underlie depressive symptoms in late life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamapsychiatry.2024.4305","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T11:33:42Z","timestamp":1737545622000},"page":"296","source":"Crossref","is-referenced-by-count":25,"title":["Depressive Symptoms and Amyloid Pathology"],"prefix":"10.1001","volume":"82","author":[{"given":"Wietse A.","family":"Wiels","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium"},{"name":"Department of Neurology, Onze-Lieve-Vrouw Hospital, Aalst, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie E.","family":"Oomens","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"Engelborghs","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Brussel, Center for Neurosciences, Neuroprotection & Neuromodulation Research Group, Brussels, Belgium"},{"name":"Departments of Neurology and Psychiatry and Bru-BRAIN, Universitair Ziekenhuis Brussel, Brussels, Belgium"},{"name":"Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Baeken","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Brussel, Center for Neurosciences, Neuroprotection & Neuromodulation Research Group, Brussels, Belgium"},{"name":"Departments of Neurology and Psychiatry and Bru-BRAIN, Universitair Ziekenhuis Brussel, Brussels, Belgium"},{"name":"Department of Head and Skin, Ghent Experimental Psychiatry Lab, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"},{"name":"Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.F.","family":"von Arnim","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, University of Goettingen Medical School, Goettingen, Germany"},{"name":"Clinic for Neurogeriatrics and Neurological Rehabilitation, University and Rehabilitation Hospital Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Boada","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona \u2013 Universitat Internacional de Catalunya, Barcelona, Spain"},{"name":"Centre for Biomedical Research Network on Neurodegenerative Diseases, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Didic","sequence":"additional","affiliation":[{"name":"Assitance Publique des Hopitaux de Marseille, Timone, Service de Neurologie et Neuropsychologie, H\u00f4pital Timone Adultes, Marseille, France"},{"name":"Aix Marseille University, National Institute of Health and Medical Research, Neurosciences des Syst\u00e8mes, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institut de la M\u00e9moire et de la Maladie d\u2019Alzheimer, Centre de R\u00e9f\u00e9rence D\u00e9mences Rares, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique\u2013 H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tormod","family":"Fladby","sequence":"additional","affiliation":[{"name":"Department of Neurology, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Centers location Vrije Universiteit Medical Center, Amsterdam, Amsterdam, the Netherlands"},{"name":"Epidemiology and Data Science, Vrije Universiteit Amsterdam, Amsterdam University Medical Centers, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[{"name":"Memory Clinic, University Hospitals and University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran Dip","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Grimmer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Klinikum Bremen-Ost, University of Oldenburg, Institute of Psychology, Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Hort","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iwatsubo","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Klimkowicz-Mrowiec","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gerontology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Research Network on Neurodegenerative Diseases, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain"},{"name":"Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Martinez-Lage","sequence":"additional","affiliation":[{"name":"Center for Research and Advanced Therapies, Cita-Alzheimer Foundation, Donostia-San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Lisbon, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp T.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth N.","family":"Kapaki","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, School of Medicine, 1st Department of Neurology, Eginition Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Parchi","sequence":"additional","affiliation":[{"name":"Istituto delle Scienze Neurologiche di Bologna, Scientific Institute for Research, Hospitalization and Healthcare, Bologna, Italy"},{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pardini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology and Maternal-Fetal Medicine, University of Genoa, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[{"name":"Centro Disturbi della Memoria, Laboratorio di Neurochimica Clinica, Clinica Neurologica, Universit\u00e0 di Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Popp","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, University Hospital of Psychiatry Z\u00fcrich and University of Z\u00fcrich, Z\u00fcrich, Switzerland"},{"name":"Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Rami","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic of Barcelona, August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Reiman","sequence":"additional","affiliation":[{"name":"Banner Alzheimer\u2019s Institute, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha O.","family":"Rinne","sequence":"additional","affiliation":[{"name":"Turku Positron Emission Tomography Centre, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Rodrigue","sequence":"additional","affiliation":[{"name":"Center for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascual","family":"S\u00e1nchez-Juan","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Research Network on Neurodegenerative Diseases, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain"},{"name":"Alzheimer\u2019s Centre Reina Sofia, Fundaci\u00f3n Centro de Investigaci\u00f3n de Enfermedades Neurol\u00f3gicas, Carlos III Institute of Health, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Coimbra, Coimbra, Portugal"},{"name":"Center for Neuroscience and Cell Biology, Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal"},{"name":"Neurology Department and Laboratory of Neurochemistry, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Sarazin","sequence":"additional","affiliation":[{"name":"Department of Neurology of Memory and Language, Groupe Hospitalier Universitaire Paris Psychiatry and Neurosciences, H\u00f4pital Sainte Anne, Paris, France"},{"name":"Paris-Saclay University, BioMaps, Inserm, Commissariat \u00e0 l'\u00e9nergie atomique et aux \u00e9nergies alternatives, Service Hospitalier Frederic Joliot, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Scarmeas","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece"},{"name":"Department of Neurology, Columbia University, New York City, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingmar","family":"Skoog","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, Kingston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa A.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"},{"name":"Harvard Aging Brain Study, Department of Neurology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada"},{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"Douglas Mental Health University Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Wallin","sequence":"additional","affiliation":[{"name":"Cognitive Medicine Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"},{"name":"Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London, United Kingdom"},{"name":"United Kingdom Dementia Research Institute, London, United Kingdom"},{"name":"Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Ossenkoppele","sequence":"additional","affiliation":[{"name":"Memory Clinic, University Hospitals and University of Geneva, Geneva, Switzerland"},{"name":"Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans R. J.","family":"Verhey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J. B.","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands"},{"name":"Department of Neurology, Akershus University Hospital, Lorenskog, Norway"},{"name":"Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemijn J.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands"},{"name":"Banner Alzheimer\u2019s Institute, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Amyloid Biomarker Study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI), the A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer\u2019s Dementia (EPAD) consortium, Fundaci\u00f3 ACE Healthy Brain Initiative (FACEHBI), Harvard Aging Brain Stud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alcolea","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Research Network on Neurodegenerative Diseases, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain"},{"name":"Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Altomare","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Baiardi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Baldeiras","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Coimbra, Coimbra, Portugal"},{"name":"Center for Neuroscience and Cell Biology, Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal"},{"name":"Neurology Department and Laboratory of Neurochemistry, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Department of Neurology and the Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Bottlaender","sequence":"additional","affiliation":[{"name":"Paris-Saclay University, BioMaps, Inserm, Commissariat \u00e0 l'\u00e9nergie atomique et aux \u00e9nergies alternatives, Service Hospitalier Frederic Joliot, Orsay, France"},{"name":"Paris-Saclay University, Research Unit in Clinical and Translational Applicative NeuroImaging, Neurospin, Commissariat \u00e0 l'\u00e9nergie atomique et aux \u00e9nergies alternatives, Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"den Braber","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Centers location Vrije Universiteit Medical Center, Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"van Buchem","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Leiden, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Cerman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[{"name":"Banner Alzheimer\u2019s Institute, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Chipi","sequence":"additional","affiliation":[{"name":"Centro Disturbi della Memoria, Laboratorio di Neurochimica Clinica, Clinica Neurologica, Universit\u00e0 di Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic in Florida, 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