{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:51:06Z","timestamp":1793278266304,"version":"4.5.0"},"reference-count":48,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Psychiatry"],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Intermittent theta-burst stimulation (iTBS) is an established treatment for treatment-resistant depression (TRD). Sessions conducted more than once daily (ie, accelerated TBS [aTBS]) may enhance antidepressant effects. However, evidence is limited to small trials, and protocols are time-consuming and can require neuroimaging-based targeting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of a pragmatic aTBS protocol for TRD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This triple-blinded, sham-controlled randomized clinical trial was conducted at a single center in S\u00e3o Paulo, Brazil, from July 2022 to June 2024, with a subsequent open-label phase. Patients aged 18 to 65 years with major depression, experiencing a TRD episode, and with a Hamilton Depression Rating Scale, 17-item (HDRS-17) score of 17 or higher were eligible for inclusion. Exclusion criteria were other psychiatric disorders (except anxiety), neurological conditions, and TBS contraindications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Participants received 45 active or sham stimulation sessions over 15 weekdays, with 3 iTBS sessions (1200 pulses each) per day, spaced 30 minutes apart and targeting the left dorsolateral prefrontal cortex using a craniometric approach. In the open-label phase, additional aTBS sessions were offered to achieve a response (\u226550% HDRS-17 score improvement) if needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>The primary outcome was change in HDRS-17 score at week 5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 431 volunteers screened, 100 participants were enrolled and randomized to either sham or active aTBS. Mean (SD) participant age was 41.7 (8.8) years, and 84 participants (84%) were female. A total of 89 patients completed the study. In the intention-to-treat analysis, the mean change in HDRS-17 scores from baseline to the study end point was 5.57 (95% CI, 3.99-7.16) in the sham group and 9.68 (95% CI, 8.11-11.25) in the active group, corresponding to 31.87% and 54.7% score reductions, respectively, and a medium-to-large effect size (Cohen\n                      <jats:italic>d<\/jats:italic>\n                      , 0.65; 95% CI, 0.29-1.00;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;amp;lt;\u2009.001). Response and remission rates were also higher in the active group. Both interventions were well tolerated, but scalp pain was more frequent in the active group than the sham group (17.4% vs 4.4%). During the open-label phase, approximately 75% of patients received additional sessions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>In this triple-blinded, sham-controlled randomized clinical trial, a pragmatic aTBS protocol using only 3 iTBS sessions per day and a nonexpensive, non-neuronavigated approach was found to be safe and effective for TRD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov Identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05388539\">NCT05388539<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamapsychiatry.2025.0013","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T11:02:21Z","timestamp":1741172541000},"page":"442","source":"Crossref","is-referenced-by-count":45,"title":["Accelerated Theta-Burst Stimulation for Treatment-Resistant Depression"],"prefix":"10.1001","volume":"82","author":[{"given":"Matheus Rassi F.","family":"Ramos","sequence":"first","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Goerigk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Ludwig-Maximilians Universit\u00e4t, Munich, Germany"},{"name":"Charlotte Fresenius Hochschule, Munich, Germany"},{"name":"DZPG (German Center for Mental Health), partner site Munich-Augsburg, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valquiria","family":"Aparecida da Silva","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Ara\u00fajo","family":"Cavendish","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Silva","family":"Pinto","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ssio Henrique Gomide","family":"Papa","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Vitor","family":"Resende","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izio","family":"Klein","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Munhoz","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Pereira","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kallene Summer Moreira","family":"Vidal","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro da Costa Lane","family":"Valiengo","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais B.","family":"Razza","sequence":"additional","affiliation":[{"name":"Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium"},{"name":"Ghent Experimental Psychiatry Laboratory, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Marotti","family":"Apar\u00edcio","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisiane","family":"Martins","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Borrione","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Batista","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha Kouvalesk","family":"Moran","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Afonso","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Benatti","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Pelosof","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Padberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Ludwig-Maximilians Universit\u00e4t, Munich, Germany"},{"name":"DZPG (German Center for Mental Health), partner site Munich-Augsburg, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre R.","family":"Brunoni","sequence":"additional","affiliation":[{"name":"Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Neuroscience and National Institute of Biomarkers in Psychiatry, Department and Institute of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"yoi250001r1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1590\/1516-4446-2017-0018","article-title":"Noninvasive brain stimulation in psychiatric disorders: a primer.","volume":"41","author":"Brunoni","year":"2019","journal-title":"Braz J Psychiatry"},{"issue":"5","key":"yoi250001r2","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1001\/archgenpsychiatry.2010.46","article-title":"Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial.","volume":"67","author":"George","year":"2010","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"yoi250001r3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/wps.20199","article-title":"Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective multicenter randomized controlled trial.","volume":"14","author":"Levkovitz","year":"2015","journal-title":"World Psychiatry"},{"issue":"10131","key":"yoi250001r4","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/S0140-6736(18)30295-2","article-title":"Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial.","volume":"391","author":"Blumberger","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"yoi250001r5","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1001\/jamapsychiatry.2020.3794","article-title":"Functional magnetic resonance imaging-guided personalization of transcranial magnetic stimulation treatment for depression.","volume":"78","author":"Cash","year":"2021","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"yoi250001r6","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41386-023-01599-z","article-title":"Accelerated TMS - moving quickly into the future of depression treatment.","volume":"49","author":"van Rooij","year":"2024","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"yoi250001r7","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.biopsych.2023.12.004","article-title":"Accelerated theta burst stimulation: safety, efficacy, and future advancements.","volume":"95","author":"Cole","year":"2024","journal-title":"Biol Psychiatry"},{"issue":"2","key":"yoi250001r8","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1176\/appi.ajp.2021.20101429","article-title":"Stanford neuromodulation therapy (SNT): a double-blind randomized controlled trial.","volume":"179","author":"Cole","year":"2022","journal-title":"Am J Psychiatry"},{"key":"yoi250001r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2023.103618","article-title":"Accelerated intermittent theta burst stimulation for major depressive disorder or bipolar depression: a systematic review and meta-analysis.","volume":"85","author":"Cai","year":"2023","journal-title":"Asian J Psychiatr"},{"key":"yoi250001r10","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.jpsychires.2022.06.038","article-title":"A transdiagnostic review of safety, efficacy, and parameter space in accelerated transcranial magnetic stimulation.","volume":"152","author":"Caulfield","year":"2022","journal-title":"J Psychiatr Res"},{"key":"yoi250001r11","doi-asserted-by":"publisher","first-page":"c332","DOI":"10.1136\/bmj.c332","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials.","volume":"340","author":"Schulz","year":"2010","journal-title":"BMJ"},{"key":"yoi250001r12","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1590\/S1516-44462000000300003","article-title":"Mini International Neuropsychiatric Interview (MINI): validation of a short structured diagnostic psychiatric interview.","volume":"22","author":"Amorim","year":"2000","journal-title":"Braz J Psychiatry"},{"issue":"1","key":"yoi250001r13","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1177\/070674370705200108","article-title":"Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.","volume":"52","author":"Berlim","year":"2007","journal-title":"Can J Psychiatry"},{"issue":"3","key":"yoi250001r14","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1176\/appi.ap.29.3.283","article-title":"Adequacy of antidepressant treatment by psychiatric residents: the antidepressant treatment history form as a possible assessment tool.","volume":"29","author":"Dew","year":"2005","journal-title":"Acad Psychiatry"},{"issue":"1","key":"yoi250001r15","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12888-018-1679-x","article-title":"Standardisation framework for the Maudsley staging method for treatment resistance in depression.","volume":"18","author":"Fekadu","year":"2018","journal-title":"BMC Psychiatry"},{"issue":"1","key":"yoi250001r16","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.brs.2008.09.006","article-title":"An efficient and accurate new method for locating the F3 position for prefrontal TMS applications.","volume":"2","author":"Beam","year":"2009","journal-title":"Brain Stimul"},{"issue":"5","key":"yoi250001r17","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.brs.2015.05.008","article-title":"Concordance between BeamF3 and MRI-neuronavigated target sites for repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex.","volume":"8","author":"Mir-Moghtadaei","year":"2015","journal-title":"Brain Stimul"},{"issue":"5","key":"yoi250001r18","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.clinph.2012.01.010","article-title":"A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee.","volume":"123","author":"Groppa","year":"2012","journal-title":"Clin Neurophysiol"},{"issue":"8","key":"yoi250001r19","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1001\/archpsyc.1988.01800320058007","article-title":"A structured interview guide for the Hamilton Depression Rating Scale.","volume":"45","author":"Williams","year":"1988","journal-title":"Arch Gen Psychiatry"},{"issue":"9","key":"yoi250001r20","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1590\/S0100-879X2005000900019","article-title":"Reliability and validity of a Portuguese version of the Young Mania Rating Scale.","volume":"38","author":"Vilela","year":"2005","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"yoi250001r22","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.rbp.2012.03.005","article-title":"Validation of the Brazilian Portuguese version of the Beck Depression Inventory-II in a community sample.","volume":"34","author":"Gomes-Oliveira","year":"2012","journal-title":"Braz J Psychiatry"},{"key":"yoi250001r23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.pnpbp.2017.10.016","article-title":"A systematic review and meta-analysis on placebo response to repetitive transcranial magnetic stimulation for depression trials.","volume":"81","author":"Razza","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"yoi250001r26","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jad.2016.04.015","article-title":"Accelerated intermittent theta burst stimulation treatment in medication-resistant major depression: a fast road to remission?","volume":"200","author":"Duprat","year":"2016","journal-title":"J Affect Disord"},{"issue":"5","key":"yoi250001r27","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.neucli.2019.10.002","article-title":"Twice-daily neuronavigated intermittent theta burst stimulation for bipolar depression: a randomized sham-controlled pilot study.","volume":"49","author":"Bulteau","year":"2019","journal-title":"Neurophysiol Clin"},{"key":"yoi250001r28","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jad.2021.04.053","article-title":"Dorsomedial prefrontal theta burst stimulation to treat anhedonia, avolition, and blunted affect in schizophrenia or depression - a randomized controlled trial.","volume":"290","author":"Bod\u00e9n","year":"2021","journal-title":"J Affect Disord"},{"issue":"6","key":"yoi250001r29","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/acps.13502","article-title":"Suicidality and relief of depressive symptoms with intermittent theta burst stimulation in a sham-controlled randomized clinical trial.","volume":"146","author":"Wilkening","year":"2022","journal-title":"Acta Psychiatr Scand"},{"issue":"6","key":"yoi250001r30","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.brs.2021.09.003","article-title":"A randomized sham controlled comparison of once vs twice-daily intermittent theta burst stimulation in depression: a Canadian rTMS treatment and biomarker network in depression (CARTBIND) study.","volume":"14","author":"Blumberger","year":"2021","journal-title":"Brain Stimul"},{"issue":"5","key":"yoi250001r31","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.brs.2021.07.018","article-title":"Accelerated theta burst stimulation for the treatment of depression: a randomised controlled trial.","volume":"14","author":"Chen","year":"2021","journal-title":"Brain Stimul"},{"issue":"2","key":"yoi250001r32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.dza.2010.04.011","article-title":"Components of placebo effect: a randomised controlled trial in patients with irritable bowel syndrome.","volume":"53","author":"Hummelsberger","year":"2010","journal-title":"Deutsche Zeitschrift f\u00fcr Akupunktur"},{"issue":"5","key":"yoi250001r33","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1016\/j.brs.2023.10.001","article-title":"Dosing transcranial magnetic stimulation in major depressive disorder: relations between number of treatment sessions and effectiveness in a large patient registry.","volume":"16","author":"Hutton","year":"2023","journal-title":"Brain Stimul"},{"issue":"8","key":"yoi250001r34","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1001\/jamapsychiatry.2024.0994","article-title":"Differential outcomes of placebo treatment across 9 psychiatric disorders: a systematic review and meta-analysis.","volume":"81","author":"Bschor","year":"2024","journal-title":"JAMA Psychiatry"},{"issue":"5","key":"yoi250001r35","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1176\/appi.ajp.2018.18091096","article-title":"Trajectories of response to dorsolateral prefrontal rTMS in major depression: a THREE-D study.","volume":"176","author":"Kaster","year":"2019","journal-title":"Am J Psychiatry"},{"issue":"4","key":"yoi250001r36","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.brs.2021.05.008","article-title":"Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: a symptom clustering approach on ELECT-TDCS.","volume":"14","author":"Goerigk","year":"2021","journal-title":"Brain Stimul"},{"issue":"11","key":"yoi250001r37","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1111\/cns.12998","article-title":"A brain network model for depression: from symptom understanding to disease intervention.","volume":"24","author":"Li","year":"2018","journal-title":"CNS Neurosci Ther"},{"issue":"5","key":"yoi250001r38","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.brs.2023.09.006","article-title":"A randomized trial comparing beam F3 and 5.5 cm targeting in rTMS treatment of depression demonstrates similar effectiveness.","volume":"16","author":"Trapp","year":"2023","journal-title":"Brain Stimul"},{"issue":"2","key":"yoi250001r39","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/s41591-023-02764-z","article-title":"Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial.","volume":"30","author":"Morriss","year":"2024","journal-title":"Nat Med"},{"key":"yoi250001r40","doi-asserted-by":"publisher","first-page":"576","DOI":"10.3389\/fnins.2020.00576","article-title":"The after-effect of accelerated intermittent theta burst stimulation at different session intervals.","volume":"14","author":"Yu","year":"2020","journal-title":"Front Neurosci"},{"issue":"12","key":"yoi250001r41","doi-asserted-by":"publisher","first-page":"3893","DOI":"10.1038\/s41380-024-02630-5","article-title":"Theta burst stimulation for depression: a systematic review and network and pairwise meta-analysis.","volume":"29","author":"Kishi","year":"2024","journal-title":"Mol Psychiatry"},{"issue":"Pt 7","key":"yoi250001r42","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1093\/brain\/awu109","article-title":"Efficacy of prefrontal theta-burst stimulation in refractory depression: a randomized sham-controlled study.","volume":"137","author":"Li","year":"2014","journal-title":"Brain"},{"issue":"7","key":"yoi250001r43","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1007\/s00406-022-01523-4","article-title":"Antidepressant effects of prolonged intermittent theta-burst stimulation monotherapy at the bilateral dorsomedial prefrontal cortex for medication and standard transcranial magnetic stimulation-resistant major depression: a three arm, randomized, double blind, sham-controlled pilot study.","volume":"273","author":"Cheng","year":"2023","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"9","key":"yoi250001r44","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.3390\/brainsci11091114","article-title":"Intermittent theta burst stimulation to the primary motor cortex reduces cortical inhibition: a TMS-EEG study.","volume":"11","author":"Bai","year":"2021","journal-title":"Brain Sci"},{"issue":"1","key":"yoi250001r45","doi-asserted-by":"publisher","first-page":"8726","DOI":"10.1038\/s41598-021-87916-2","article-title":"Determining the optimal pulse number for theta burst induced change in cortical excitability.","volume":"11","author":"McCalley","year":"2021","journal-title":"Sci Rep"},{"key":"yoi250001r46","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.clinph.2021.12.018","article-title":"Dose-response of intermittent theta burst stimulation of the prefrontal cortex: a TMS-EEG study.","volume":"136","author":"Desforges","year":"2022","journal-title":"Clin Neurophysiol"},{"key":"yoi250001r47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2024.08.009","article-title":"Dose-dependent target engagement of a clinical intermittent theta burst stimulation protocol: an interleaved transcranial magnetic stimulation-functional magnetic resonance imaging study in healthy people.","author":"Chang","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"yoi250001r48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2024.120596","article-title":"Neural response during prefrontal theta burst stimulation: interleaved TMS-fMRI of full iTBS protocols.","volume":"291","author":"Chang","year":"2024","journal-title":"Neuroimage"},{"key":"yoi250001r21","volume-title":"ECDEU Assessment Manual for Psychopharmacology","author":"Guy","year":"1976"},{"key":"yoi250001r24","unstructured":"The R Core Team. R: a language and environment for statistical computing. Accessed October 1, 2024. https:\/\/cran.r-project.org\/doc\/manuals\/r-release\/fullrefman.pdf"},{"key":"yoi250001r25","unstructured":"emmeans: estimated marginal means, aka least-squares means [R package emmeans version 1.10.2]. R Project. Accessed May 20, 2024. https:\/\/cran.r-project.org\/web\/packages\/emmeans\/index.html"}],"container-title":["JAMA Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/articlepdf\/2830861\/jamapsychiatry_ramos_2025_oi_250001_1745421092.17591.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T11:53:28Z","timestamp":1746618808000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2830861"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamapsychiatry.2025.0013","relation":{},"ISSN":["2168-622X"],"issn-type":[{"value":"2168-622X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,1]]}}}