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However, more research is needed to establish causal inferences between brain changes, EWB, and behavioral changes observed in typical aging and ADRD.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ysc250001-2\"><jats:title>Observations<\/jats:title><jats:p>This article presents a framework for using a cross-species behavioral neuroscience approach to study EWB and brain aging, adopting a well-established biobehavioral model that highlights the reciprocal roles of brain changes, EWB, and ADRD symptoms. First, the challenges and opportunities in this field are reviewed. Then, a practical solution to improve comparability between animal and human studies is proposed.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ysc250001-3\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The goal is to draw comprehensive parallels and distinctions that could enhance the understanding of the mechanisms linking brain aging, EWB, and ADRD symptomatic disturbances across different species.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamapsychiatry.2025.0581","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T15:54:17Z","timestamp":1746633257000},"page":"734","source":"Crossref","is-referenced-by-count":4,"title":["Cross-Species Framework for Emotional Well-Being and Brain Aging"],"prefix":"10.1001","volume":"82","author":[{"given":"F. 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