{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:50:05Z","timestamp":1790599805240,"version":"4.1.0"},"reference-count":43,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Surg"],"published-print":{"date-parts":[[2020,8,1]]},"DOI":"10.1001\/jamasurg.2020.1501","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T16:05:38Z","timestamp":1592409938000},"page":"703","source":"Crossref","is-referenced-by-count":51,"title":["Efficacy and Safety of Ursodeoxycholic Acid for the Prevention of Gallstone Formation After Gastrectomy in Patients With Gastric Cancer"],"prefix":"10.1001","volume":"155","author":[{"given":"Sang Hyub","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Kee","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-Won","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hwi","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Yeob","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Kyoung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoungpook National University Chilgok Hospital, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon","family":"Hur","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ajou University Hospital, Suwon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Man Yoon","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer, National Cancer Center, Goyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang Wool","family":"Eom","sequence":"additional","affiliation":[{"name":"Center for Gastric Cancer, National Cancer Center, Goyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Seong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Surgery, Boramae Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeil","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yonsei University Severance Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyo Young","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catholic University of Seoul St Mary\u2019s Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Hong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catholic University of Seoul St Mary\u2019s Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Gew","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeong","family":"An","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Il","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyeon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Suk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Joong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea"},{"name":"Department of Surgery and Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Efficacy and Safety of DWJ1319 in the Prevention of Gallstone Formation after Gastrectomy in Patient with Gastric Cancer: A Multicenter, Randomized, Double-blind, Placebo-controlled Study (PEGASUS-D) Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"2","key":"soi200032r1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.5230\/jgc.2016.16.2.98","article-title":"Risk factors for gallstone formation after surgery for gastric cancer.","volume":"16","author":"Park","year":"2016","journal-title":"J Gastric Cancer"},{"issue":"11","key":"soi200032r2","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1002\/(ISSN)1365-2168","article-title":"Analysis of risk factors for the development of gallstones after gastrectomy.","volume":"92","author":"Kobayashi","year":"2005","journal-title":"Br J Surg"},{"issue":"5","key":"soi200032r3","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1007\/s11605-009-0832-8","article-title":"Gallstone formation after gastric cancer surgery.","volume":"13","author":"Fukagawa","year":"2009","journal-title":"J Gastrointest Surg"},{"issue":"4","key":"soi200032r4","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s00268-016-3831-4","article-title":"Is routine prophylactic cholecystectomy necessary during gastrectomy for gastric cancer?","volume":"41","author":"Kimura","year":"2017","journal-title":"World J Surg"},{"issue":"11","key":"soi200032r5","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1007\/s00464-009-0422-6","article-title":"Symptomatic gallstones after sleeve gastrectomy.","volume":"23","author":"Li","year":"2009","journal-title":"Surg Endosc"},{"issue":"6","key":"soi200032r6","first-page":"463","article-title":"Conversion in laparoscopic cholecystectomy after gastric resection: a 15-year review.","volume":"52","author":"Fraser","year":"2009","journal-title":"Can J Surg"},{"issue":"9","key":"soi200032r7","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1007\/s00595-007-3726-y","article-title":"Laparoscopic cholecystectomy in patients with a history of gastrectomy.","volume":"38","author":"Sasaki","year":"2008","journal-title":"Surg Today"},{"issue":"9","key":"soi200032r8","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s11894-013-0343-3","article-title":"ERCP in the patient with surgically altered anatomy.","volume":"15","author":"Moreels","year":"2013","journal-title":"Curr Gastroenterol Rep"},{"issue":"4","key":"soi200032r9","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1381\/096089203322190862","article-title":"Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery.","volume":"13","author":"Igl\u00e9zias Brand\u00e3o de Oliveira","year":"2003","journal-title":"Obes Surg"},{"issue":"1","key":"soi200032r10","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0016-5085(92)91813-J","article-title":"Antral control of gallbladder cyclic motor activity in the fasting state.","volume":"102","author":"Ura","year":"1992","journal-title":"Gastroenterology"},{"issue":"3","key":"soi200032r11","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/00000658-198503000-00010","article-title":"Gallstone disease following antrectomy and gastroduodenostomy with or without vagotomy.","volume":"201","author":"Rehnberg","year":"1985","journal-title":"Ann Surg"},{"issue":"14","key":"soi200032r12","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.3748\/wjg.v13.i14.2066","article-title":"Surgical anatomy of innervation of the gallbladder in humans and Suncus murinus with special reference to morphological understanding of gallstone formation after gastrectomy.","volume":"13","author":"Yi","year":"2007","journal-title":"World J Gastroenterol"},{"issue":"1","key":"soi200032r13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/S0002-9610(05)80573-2","article-title":"Influence of the method of digestive tract reconstruction on gallstone development after total gastrectomy for gastric cancer.","volume":"166","author":"Pezzolla","year":"1993","journal-title":"Am J Surg"},{"issue":"8","key":"soi200032r14","first-page":"672","article-title":"Impaired contractile motility of the gallbladder after gastrectomy.","volume":"81","author":"Takahashi","year":"1986","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"soi200032r15","first-page":"27","article-title":"Release of cholecystokinin and gallbladder contraction before and after gastrectomy.","volume":"205","author":"Inoue","year":"1987","journal-title":"Ann Surg"},{"issue":"12","key":"soi200032r16","doi-asserted-by":"publisher","first-page":"3444","DOI":"10.1111\/j.1572-0241.2000.03282.x","article-title":"The effect of acute oral erythromycin on gallbladder motility and on upper gastrointestinal symptoms in gastrectomized patients with and without gallstones: a randomized, placebo-controlled ultrasonographic study.","volume":"95","author":"Portincasa","year":"2000","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"soi200032r17","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1007\/s10120-018-0879-x","article-title":"The Cholegas trial: long-term results of prophylactic cholecystectomy during gastrectomy for cancer\u2014a randomized-controlled trial.","volume":"22","author":"Bencini","year":"2019","journal-title":"Gastric Cancer"},{"issue":"6","key":"soi200032r18","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.soard.2016.12.012","article-title":"Safety of concomitant cholecystectomy at the time of laparoscopic sleeve gastrectomy: analysis of the American College of Surgeons National Surgical Quality Improvement Program database.","volume":"13","author":"Dakour-Aridi","year":"2017","journal-title":"Surg Obes Relat Dis"},{"issue":"2","key":"soi200032r19","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s11695-017-2867-3","article-title":"Is concomitant cholecystectomy necessary for asymptomatic cholelithiasis during laparoscopic sleeve gastrectomy?","volume":"28","author":"Yardimci","year":"2018","journal-title":"Obes Surg"},{"issue":"6","key":"soi200032r20","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/ajg.2013.70","article-title":"Relationship of non-alcoholic fatty liver disease with cholecystectomy in the US population.","volume":"108","author":"Ruhl","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"soi200032r21","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1007\/s004640000019","article-title":"Laparoscopic cholecystectomy in morbidly obese patients.","volume":"15","author":"Ammori","year":"2001","journal-title":"Surg Endosc"},{"issue":"4","key":"soi200032r22","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.soard.2016.11.022","article-title":"Evaluation of incidence of cholelithiasis after bariatric surgery in subjects treated or not treated with ursodeoxycholic acid.","volume":"13","author":"Coupaye","year":"2017","journal-title":"Surg Obes Relat Dis"},{"issue":"12","key":"soi200032r23","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1007\/s11695-008-9587-7","article-title":"Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis.","volume":"18","author":"Uy","year":"2008","journal-title":"Obes Surg"},{"issue":"5","key":"soi200032r24","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1097\/01.sla.0000094305.77843.cf","article-title":"Gallstone formation prophylaxis after gastric restrictive procedures for weight loss: a randomized double-blind placebo-controlled trial.","volume":"238","author":"Miller","year":"2003","journal-title":"Ann Surg"},{"issue":"1","key":"soi200032r25","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1006\/jsre.2001.6322","article-title":"Prevention of gallstone formation in morbidly obese patients undergoing rapid weight loss: results of a randomized controlled pilot study.","volume":"102","author":"Wudel","year":"2002","journal-title":"J Surg Res"},{"issue":"3","key":"soi200032r26","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1381\/096089293765559278","article-title":"A double-blind placebo-controlled trial of ursodeoxycholic acid in the prevention of gallstones during weight loss after vertical banded gastroplasty.","volume":"3","author":"Williams","year":"1993","journal-title":"Obes Surg"},{"issue":"7","key":"soi200032r27","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1007\/s00595-016-1446-x","article-title":"Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy.","volume":"47","author":"Abdallah","year":"2017","journal-title":"Surg Today"},{"issue":"1","key":"soi200032r28","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1023\/A:1026635124115","article-title":"Effects of ursodeoxycholic acid therapy on in vitro gallbladder contractility in patients with cholesterol gallstones.","volume":"44","author":"van de Heijning","year":"1999","journal-title":"Dig Dis Sci"},{"issue":"6","key":"soi200032r29","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1136\/gut.2006.109934","article-title":"Ursodeoxycholic acid improves muscle contractility and inflammation in symptomatic gallbladders with cholesterol gallstones.","volume":"56","author":"Guarino","year":"2007","journal-title":"Gut"},{"issue":"1","key":"soi200032r30","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/S0016-5085(94)94899-2","article-title":"Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid.","volume":"106","author":"Jazrawi","year":"1994","journal-title":"Gastroenterology"},{"issue":"3","key":"soi200032r31","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1053\/jhep.2002.36088","article-title":"Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited.","volume":"36","author":"Paumgartner","year":"2002","journal-title":"Hepatology"},{"issue":"20","key":"soi200032r32","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"issue":"6","key":"soi200032r33","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","article-title":"Toxicity and response criteria of the Eastern Cooperative Oncology Group.","volume":"5","author":"Oken","year":"1982","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"soi200032r34","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1148\/radiographics.20.3.g00ma16751","article-title":"Gallbladder stones: imaging and intervention.","volume":"20","author":"Bortoff","year":"2000","journal-title":"Radiographics"},{"issue":"1","key":"soi200032r35","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0002-9610(99)80115-9","article-title":"A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass\u2013induced rapid weight loss.","volume":"169","author":"Sugerman","year":"1995","journal-title":"Am J Surg"},{"issue":"1","key":"soi200032r36","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/00000658-199201000-00002","article-title":"Gallbladder sludge and stone formation in relation to contractile function after gastrectomy: a prospective study.","volume":"215","author":"Inoue","year":"1992","journal-title":"Ann Surg"},{"issue":"6","key":"soi200032r37","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1177\/2168479016651660","article-title":"Current practice on multiplicity adjustment and sample size calculation in multi-arm clinical trials: an industry survey in Japan.","volume":"50","author":"Sakamaki","year":"2016","journal-title":"Ther Innov Regul Sci"},{"issue":"1","key":"soi200032r38","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s12876-017-0674-x","article-title":"Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery: study protocol for a randomized controlled trial (UPGRADE trial).","volume":"17","author":"Boerlage","year":"2017","journal-title":"BMC Gastroenterol"},{"issue":"2","key":"soi200032r39","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s00268-003-6879-x","article-title":"Changing patterns of gallstone disease in Korea.","volume":"28","author":"Park","year":"2004","journal-title":"World J Surg"},{"issue":"2","key":"soi200032r40","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5230\/jgc.2017.17.e12","article-title":"Actual 5-year nutritional outcomes of patients with gastric cancer.","volume":"17","author":"Kim","year":"2017","journal-title":"J Gastric Cancer"},{"key":"soi200032r41","doi-asserted-by":"publisher","first-page":"g6241","DOI":"10.1136\/bmj.g6241","article-title":"Diagnosis and management of gallstone disease: summary of NICE guidance.","volume":"349","author":"Warttig","year":"2014","journal-title":"BMJ"},{"issue":"1","key":"soi200032r42","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1002\/(ISSN)1527-3350","article-title":"Long-term ursodeoxycholic acid therapy is associated with reduced risk of biliary pain and acute cholecystitis in patients with gallbladder stones: a cohort analysis.","volume":"30","author":"Tomida","year":"1999","journal-title":"Hepatology"},{"issue":"10","key":"soi200032r43","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1046\/j.1365-2036.2003.01792.x","article-title":"Systematic review: ursodeoxycholic acid\u2014adverse effects and drug interactions.","volume":"18","author":"Hempfling","year":"2003","journal-title":"Aliment Pharmacol Ther"}],"container-title":["JAMA Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamasurgery\/articlepdf\/2767403\/jamasurgery_lee_2020_oi_200032_1597783643.07007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T15:03:07Z","timestamp":1597849387000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamasurgery\/fullarticle\/2767403"}},"subtitle":["The PEGASUS-D Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamasurg.2020.1501","relation":{},"ISSN":["2168-6254"],"issn-type":[{"value":"2168-6254","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8,1]]}}}