{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:41:22Z","timestamp":1791654082670,"version":"4.3.4"},"reference-count":21,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Surg"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:sec id=\"ab-soi220010-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Colorectal cancer is a leading cause of cancer-related death, and nearly 70% of patients with this cancer have unresectable colorectal cancer liver metastases (CRLMs). Compared with chemotherapy, liver transplant has been reported to improve survival in patients with CRLMs, but in North America, liver allograft shortages make the use of deceased-donor allografts for this indication problematic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi220010-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine survival outcomes of living-donor liver transplant (LDLT) for unresectable, liver-confined CRLMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi220010-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This prospective cohort study included patients at 3 North American liver transplant centers with established LDLT programs, 2 in the US and 1 in Canada. Patients with liver-confined, unresectable CRLMs who had demonstrated sustained disease control on oncologic therapy met the inclusion criteria for LDLT. Patients included in this study underwent an LDLT between July 2017 and October 2020 and were followed up until May 1, 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi220010-7\">\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>Living-donor liver transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi220010-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Perioperative morbidity and mortality of treated patients and donors, assessed by univariate statistics, and 1.5-year Kaplan-Meier estimates of recurrence-free and overall survival for transplant recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi220010-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 91 evaluated patients, 10 (11%) underwent LDLT (6 [60%] male; median age, 45 years [range, 35-58 years]). Among the 10 living donors, 7 (70%) were male, and the median age was 40.5 years (range, 27-50 years). Kaplan-Meier estimates for recurrence-free and overall survival at 1.5 years after LDLT were 62% and 100%, respectively. Perioperative morbidity for both donors and recipients was consistent with established standards (Clavien-Dindo complications among recipients: 3 [10%] had none, 3 [30%] had grade II, and 4 [40%] had grade III; donors: 5 [50%] had none, 4 [40%] had grade I, and 1 had grade III).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi220010-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>This study\u2019s findings of recurrence-free and overall survival rates suggest that select patients with unresectable, liver-confined CRLMs may benefit from total hepatectomy and LDLT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamasurg.2022.0300","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T16:04:12Z","timestamp":1648656252000},"page":"524","source":"Crossref","is-referenced-by-count":114,"title":["Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases"],"prefix":"10.1001","volume":"157","author":[{"given":"Roberto","family":"Hernandez-Alejandro","sequence":"first","affiliation":[{"name":"Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis I.","family":"Ruffolo","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Tomiyama","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Orloff","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Pineda-Solis","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Nair","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Errigo","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Katherine","family":"Dokus","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Cattral","sequence":"additional","affiliation":[{"name":"HPB and Multi-Organ Transplant Program, Division of General Surgery, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"McGilvray","sequence":"additional","affiliation":[{"name":"HPB and Multi-Organ Transplant Program, Division of General Surgery, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Ghanekar","sequence":"additional","affiliation":[{"name":"HPB and Multi-Organ Transplant Program, Division of General Surgery, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gallinger","sequence":"additional","affiliation":[{"name":"HPB and Multi-Organ Transplant Program, Division of General Surgery, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia","family":"Selzner","sequence":"additional","affiliation":[{"name":"HPB and Multi-Organ Transplant Program, Division of General Surgery, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco P. A. W.","family":"Claasen","sequence":"additional","affiliation":[{"name":"HPB and Multi-Organ Transplant Program, Division of General Surgery, University Health Network, Toronto, Ontario, Canada"},{"name":"Division of HPB and Transplant Surgery, Department of Surgery, Erasmus MC Transplant Institute, University Medical Centre Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Burkes","sequence":"additional","affiliation":[{"name":"HPB and Multi-Organ Transplant Program, Division of General Surgery, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Fujiki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Quintini","sequence":"additional","affiliation":[{"name":"Department of Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam N.","family":"Estfan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Cancer Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon Hyuck David","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. V. Narayanan","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Aucejo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Sapisochin","sequence":"additional","affiliation":[{"name":"HPB and Multi-Organ Transplant Program, Division of General Surgery, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"2","key":"soi220010r1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/00000658-198908000-00001","article-title":"Resection of hepatic metastases from colorectal cancer. Biologic perspective.","volume":"210","author":"Steele","year":"1989","journal-title":"Ann Surg"},{"issue":"6","key":"soi220010r2","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.v68.6","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"soi220010r3","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/00000658-199610000-00009","article-title":"Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy.","volume":"224","author":"Bismuth","year":"1996","journal-title":"Ann Surg"},{"key":"soi220010r4","doi-asserted-by":"publisher","first-page":"iii1","DOI":"10.1136\/gut.2006.098053","article-title":"Guidelines for resection of colorectal cancer liver metastases.","volume":"55","author":"Garden","year":"2006","journal-title":"Gut"},{"key":"soi220010r5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ejca.2016.10.028","article-title":"Efficacy of FOLFOXIRI plus bevacizumab in liver-limited metastatic colorectal cancer: a pooled analysis of clinical studies by Gruppo Oncologico del Nord Ovest.","volume":"73","author":"Cremolini","year":"2017","journal-title":"Eur J Cancer"},{"issue":"5","key":"soi220010r6","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1097\/SLA.0000000000000786","article-title":"Chemotherapy or liver transplantation for nonresectable liver metastases from colorectal cancer?","volume":"261","author":"Dueland","year":"2015","journal-title":"Ann Surg"},{"key":"soi220010r8","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/ajt.v21.s2","article-title":"OPTN\/SRTR 2019 Annual Data Report: Liver.","volume":"21","author":"Kwong","year":"2021","journal-title":"Am J Transplant"},{"issue":"2","key":"soi220010r9","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/ajt.15144","article-title":"Liver transplantation and waitlist mortality for HCC and non-HCC candidates following the 2015 HCC exception policy change.","volume":"19","author":"Ishaque","year":"2019","journal-title":"Am J Transplant"},{"issue":"8","key":"soi220010r10","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1111\/tri.2013.26.issue-8","article-title":"Living donor versus deceased donor liver transplantation: a surgeon-matched comparison of recipient morbidity and outcomes.","volume":"26","author":"Reichman","year":"2013","journal-title":"Transpl Int"},{"issue":"9","key":"soi220010r11","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.3112","article-title":"Evaluation of the intention-to-treat benefit of living donation in patients with hepatocellular carcinoma awaiting a liver transplant.","volume":"156","author":"Lai","year":"2021","journal-title":"JAMA Surg"},{"issue":"11","key":"soi220010r12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S2468-1253(21)00219-3","article-title":"Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines.","volume":"6","author":"Bonney","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"2","key":"soi220010r13","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/SLA.0000000000003404","article-title":"Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases.","volume":"271","author":"Dueland","year":"2020","journal-title":"Ann Surg"},{"issue":"5","key":"soi220010r14","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/SLA.0b013e3182823957","article-title":"Liver transplantation for nonresectable liver metastases from colorectal cancer.","volume":"257","author":"Hagness","year":"2013","journal-title":"Ann Surg"},{"issue":"3","key":"soi220010r15","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1097\/00000658-199909000-00004","article-title":"Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.","volume":"230","author":"Fong","year":"1999","journal-title":"Ann Surg"},{"issue":"6","key":"soi220010r16","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/j.jhep.2020.08.015","article-title":"Liver transplantation for secondary liver tumours: The difficult balance between survival and recurrence.","volume":"73","author":"Line","year":"2020","journal-title":"J Hepatol"},{"issue":"2","key":"soi220010r17","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1111\/ajt.v20.2","article-title":"Selection criteria related to long-term survival following liver transplantation for colorectal liver metastasis.","volume":"20","author":"Dueland","year":"2020","journal-title":"Am J Transplant"},{"issue":"2","key":"soi220010r18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/PO.18.00195","article-title":"Targeted therapy for colorectal cancers with non-V600 BRAF mutations: perspectives for precision oncology.","volume":"2","author":"Dankner","year":"2018","journal-title":"JCO Precis Oncol"},{"issue":"3","key":"soi220010r19","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1159\/000447402","article-title":"Colorectal cancer with BRAF D594G mutation is not associated with microsatellite instability or poor prognosis.","volume":"91","author":"Amaki-Takao","year":"2016","journal-title":"Oncology"},{"key":"soi220010r20","doi-asserted-by":"publisher","first-page":"S128","DOI":"10.1002\/lt.v17.2s","article-title":"Should we use living donor grafts for patients with hepatocellular carcinoma? ethical considerations.","volume":"17","author":"Pomfret","year":"2011","journal-title":"Liver Transpl"},{"issue":"3","key":"soi220010r21","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/SLA.0000000000004071","article-title":"Transplant oncology in primary and metastatic liver tumors: principles, evidence, and opportunities.","volume":"273","author":"Sapisochin","year":"2021","journal-title":"Ann Surg"},{"key":"soi220010r7","unstructured":"Scientific Registry of Transplant Recipients. OPTN\/SRTR 2019 annual data report: liver. Health Resources and Services Administration. Accessed July 15, 2021. https:\/\/srtr.transplant.hrsa.gov\/annual_reports\/2019\/Liver.aspx"}],"container-title":["JAMA Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamasurgery\/articlepdf\/2790533\/jamasurgery_hernandezalejandro_2022_oi_220010_1664203003.84546.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T11:00:42Z","timestamp":1664362842000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamasurgery\/fullarticle\/2790533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamasurg.2022.0300","relation":{},"ISSN":["2168-6254"],"issn-type":[{"value":"2168-6254","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,1]]}}}