{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:16:57Z","timestamp":1792225017434,"version":"4.4.0"},"reference-count":20,"publisher":"American Medical Association (AMA)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Surg"],"DOI":"10.1001\/jamasurg.2022.2055","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T11:02:08Z","timestamp":1659524528000},"source":"Crossref","is-referenced-by-count":24,"title":["Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma"],"prefix":"10.1001","author":[{"name":"Multicenter Selective Lymphadenectomy Trials Study Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica S.","family":"Crystal","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia, The University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hyngstrom","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Utah, Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Carac\u00f2","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori IRCCS Fondazione \u201cG. Pascale,\u201d Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Zager","sequence":"additional","affiliation":[{"name":"Departments of Cutaneous Oncology and Sarcoma, H. Lee Moffitt Cancer Center, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Jahkola","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University of Helsinki, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawnya L.","family":"Bowles","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Intermountain Medical Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Pennacchioli","sequence":"additional","affiliation":[{"name":"Division of Melanoma, Soft Tissue Sarcomas and Rare Tumors, European Institute of Oncology, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Beitsch","sequence":"additional","affiliation":[{"name":"Dallas Surgical Group, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald J.","family":"Hoekstra","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Moncrieff","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Norfolk and Norwich University Hospital, Norwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ingvar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"van Akkooi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Sabel","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Wake Forest University, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Agnese","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ohio State University, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Melbourne, Peter MacCallum Cancer Centre, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Dummer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogerio","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of Surgery, Pennsylvania State University Milton S. Hershey Medical Center, Hershey"},{"name":"Now at Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Riccardo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Melanoma and Sarcomas Unit, Veneto Institute of Oncology, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John M.","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Trocha","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Prisma Health, Columbia, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Byrd","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington, Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Matter","sequence":"additional","affiliation":[{"name":"Department of Surgery, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy C.","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"MacKenzie-Ross","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Terheyden","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Lubeck, Lubeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara L.","family":"Huston","sequence":"additional","affiliation":[{"name":"Department of Surgery, Stony Brook University, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Wayne","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Neuman","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Wisconsin at Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Mark","family":"Smithers","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Ariyan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saint Luke\u2019s University Hospital, Bethlehem, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Gershenwald","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Schneebaum","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Gesierich","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Wurzburg, Wurzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa K.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Medical Center, Knoxville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"McMasters","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"O\u2019Donoghue","sequence":"additional","affiliation":[{"name":"Department of Surgery, Rush University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"van der Westhuizen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Calvary Mater Hospital, Waratah, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Sardi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Mercy Medical Center, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Barth","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Barone","sequence":"additional","affiliation":[{"name":"Surgical Oncology, Sharp Hospital, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Greg","family":"McKinnon","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig L.","family":"Slingluff","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Virginia, Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Farma","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Nuremberg General Hospital, Paracelsus Medical Center, Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall P.","family":"Scheri","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Vidal-Sicart","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Hospital Clinic Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Surgery, Lakeland Regional Health, Lakeland, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro A. E.","family":"Testori","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Image Regenerative Clinic, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leland J.","family":"Foshag","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Van Kreuningen","sequence":"additional","affiliation":[{"name":"Manager of Research Operations, Saint John\u2019s Cancer Institute, Santa Monica, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine Statistics Core, David Geffen School of Medicine at UCLA, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Shin","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia, Department of Medicine, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Elashoff","sequence":"additional","affiliation":[{"name":"Department of Medicine Statistics Core, David Geffen School of Medicine at UCLA, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair J.","family":"Cochran","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, David Geffen School of Medicine at UCLA, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B.","family":"Faries","sequence":"additional","affiliation":[{"name":"The Angeles Clinic and Research Institute, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"issue":"4","key":"soi220030r1","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1001\/archsurg.1992.01420040034005","article-title":"Technical details of intraoperative lymphatic mapping for early stage melanoma.","volume":"127","author":"Morton","year":"1992","journal-title":"Arch Surg"},{"issue":"10","key":"soi220030r2","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1007\/s10434-001-0766-1","article-title":"Improved staging of node-negative patients with intermediate to thick melanomas (&gt;1 mm) with the use of lymphatic mapping and sentinel lymph node biopsy.","volume":"8","author":"Dessureault","year":"2001","journal-title":"Ann Surg Oncol"},{"issue":"7","key":"soi220030r3","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1056\/NEJMoa1310460","article-title":"Final trial report of sentinel-node biopsy versus nodal observation in melanoma.","volume":"370","author":"Morton","year":"2014","journal-title":"N Engl J Med"},{"issue":"10","key":"soi220030r4","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1200\/JCO.2015.63.3776","article-title":"Final results of the Sunbelt Melanoma Trial: a multi-institutional prospective randomized phase III study evaluating the role of adjuvant high-dose interferon alfa-2b and completion lymph node dissection for patients staged by sentinel lymph node biopsy.","volume":"34","author":"McMasters","year":"2016","journal-title":"J Clin Oncol"},{"issue":"23","key":"soi220030r5","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1056\/NEJMoa1613210","article-title":"Completion dissection or observation for sentinel-node metastasis in melanoma.","volume":"376","author":"Faries","year":"2017","journal-title":"N Engl J Med"},{"issue":"32","key":"soi220030r6","doi-asserted-by":"publisher","first-page":"3000","DOI":"10.1200\/JCO.18.02306","article-title":"Final analysis of DeCOG-SLT trial: no survival benefit for complete lymph node dissection in patients with melanoma with positive sentinel node.","volume":"37","author":"Leiter","year":"2019","journal-title":"J Clin Oncol"},{"issue":"4","key":"soi220030r7","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1097\/SLA.0000000000003405","article-title":"Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial.","volume":"273","author":"Thompson","year":"2021","journal-title":"Ann Surg"},{"issue":"6","key":"soi220030r8","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1097\/00000658-199412000-00009","article-title":"The orderly progression of melanoma nodal metastases.","volume":"220","author":"Reintgen","year":"1994","journal-title":"Ann Surg"},{"issue":"5","key":"soi220030r9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1245\/ASO.2003.03.054","article-title":"The amount of metastatic melanoma in a sentinel lymph node: does it have prognostic significance?","volume":"10","author":"Carlson","year":"2003","journal-title":"Ann Surg Oncol"},{"issue":"10","key":"soi220030r10","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1093\/annonc\/mdl176","article-title":"Clinical relevance of melanoma micrometastases (&lt;0.1 mm) in sentinel nodes: are these nodes to be considered negative?","volume":"17","author":"van Akkooi","year":"2006","journal-title":"Ann Oncol"},{"issue":"12","key":"soi220030r11","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1038\/sj.bjc.6604407","article-title":"The influence of sentinel lymph node tumour burden on additional lymph node involvement and disease-free survival in cutaneous melanoma\u2014a retrospective analysis of 392 cases.","volume":"98","author":"Guggenheim","year":"2008","journal-title":"Br J Cancer"},{"key":"soi220030r12","first-page":"100","article-title":"Evaluation of melanoma in non-sentinel nodes: how much is enough?","volume":"17","author":"Wen","year":"2004","journal-title":"Mod Pathol"},{"issue":"4","key":"soi220030r13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/01.cmr.0000136708.90534.71","article-title":"Immunohistochemical stains fail to increase the detection rate of micrometastatic melanoma in completion regional lymph node dissection specimens.","volume":"14","author":"Scolyer","year":"2004","journal-title":"Melanoma Res"},{"issue":"26","key":"soi220030r14","doi-asserted-by":"publisher","first-page":"4296","DOI":"10.1200\/JCO.2007.15.4179","article-title":"Microscopic tumor burden in sentinel lymph nodes predicts synchronous nonsentinel lymph node involvement in patients with melanoma.","volume":"26","author":"Gershenwald","year":"2008","journal-title":"J Clin Oncol"},{"issue":"4","key":"soi220030r15","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jamcollsurg.2013.12.014","article-title":"Comparison of sentinel lymph node micrometastatic tumor burden measurements in melanoma.","volume":"218","author":"Egger","year":"2014","journal-title":"J Am Coll Surg"},{"issue":"1","key":"soi220030r16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ejca.2013.08.023","article-title":"The prognostic significance of sentinel node tumour burden in melanoma patients: an international, multicenter study of 1539 sentinel node-positive melanoma patients.","volume":"50","author":"van der Ploeg","year":"2014","journal-title":"Eur J Cancer"},{"issue":"12","key":"soi220030r17","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1038\/modpathol.2015.110","article-title":"Tumor PD-L1 expression, immune cell correlates and PD-1+ lymphocytes in sentinel lymph node melanoma metastases.","volume":"28","author":"Kakavand","year":"2015","journal-title":"Mod Pathol"},{"issue":"6","key":"soi220030r18","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.amjoto.2014.08.009","article-title":"FoxP3 and indoleamine 2,3-dioxygenase immunoreactivity in sentinel nodes from melanoma patients.","volume":"35","author":"Ryan","year":"2014","journal-title":"Am J Otolaryngol"},{"issue":"13","key":"soi220030r19","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.ejca.2011.09.007","article-title":"Indoleamine 2,3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients.","volume":"48","author":"Speeckaert","year":"2012","journal-title":"Eur J Cancer"},{"issue":"4","key":"soi220030r20","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.suronc.2010.11.001","article-title":"Clinico-pathologic features of primary melanoma and sentinel lymph node predictive for non-sentinel lymph node involvement and overall survival in melanoma patients: a single centre observational cohort study.","volume":"20","author":"Quaglino","year":"2011","journal-title":"Surg Oncol"}],"container-title":["JAMA Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamasurgery\/articlepdf\/2794852\/jamasurgery_crystal_2022_oi_220030_1658774896.99694.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T11:02:11Z","timestamp":1659524531000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamasurgery\/fullarticle\/2794852"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":20,"URL":"https:\/\/doi.org\/10.1001\/jamasurg.2022.2055","relation":{},"ISSN":["2168-6254"],"issn-type":[{"value":"2168-6254","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,3]]}}}