{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:36:08Z","timestamp":1789907768290,"version":"4.0.1"},"reference-count":50,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Surg"],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:sec id=\"ab-soi240081-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Ongoing efforts have encouraged the regionalization of esophageal adenocarcinoma treatment to high-volume centers (HVCs). Yet such centralization has been linked with increased patient travel burden and reduced postoperative continuity of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi240081-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether traveling to undergo esophagectomy at HVCs is linked with superior overall survival compared with receiving care locally at low-volume centers (LVC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi240081-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This cohort study considered data for all patients diagnosed with stage I through III esophageal adenocarcinoma in the 2010-2021 National Cancer Database. Patients were stratified based on distance traveled to receive care and the annual esophagectomy volume at the treating hospital: the travel-HVC cohort included patients in the top 25th percentile of travel burden who received care at centers in the top volume quartile, and the local-LVC cohort represented those in the bottom 25th percentile of travel burden who were treated at centers in the lowest volume quartile. Data were analyzed from July 2023 to January 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi240081-7\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>The primary end points were overall survival at 1 year and 5 years. Secondary end points included perioperative outcomes and factors linked with traveling to receive care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi240081-8\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 17\u202f970 patients, 2342 (13%) comprised the travel-HVC cohort, and 1969 (11%), the local-LVC cohort. The median (IQR) age was 65 (58-71) years; 3748 (87%) were male and 563 (13%) were female. After risk adjustment and with care at local LVCs as the reference, traveling to HVC was associated with superior survival at 1 year (hazard ratio for mortality [HR], 0.69; 95% CI, 0.58-0.83) and 5 years (HR, 0.80; 95% CI, 0.70-0.90). Stratifying by stage, traveling to HVCs was associated with comparable outcomes for stage I disease but reduced mortality for stage III (1-year HR, 0.72; 95% CI, 0.60-0.87; 5-year HR, 0.83; 95% CI, 0.74-0.93). Further, traveling to HVC was associated with greater lymph node harvest (\u03b2, 5.08 nodes; 95% CI, 3.78-6.37) and likelihood of margin-negative resection (adjusted odds ratio, 1.83; 95% CI, 1.29-2.60).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-soi240081-9\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>Traveling to HVCs for esophagectomy was associated with improved 1-year and 5-year survival compared with receiving care locally at LVCs, particularly among patients with locoregionally advanced disease. Future studies are needed to ascertain barriers to care and develop novel targeted pathways to ensure equitable access to high-volume facilities and high-quality oncologic care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamasurg.2024.5009","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T11:31:30Z","timestamp":1731497490000},"page":"19","source":"Crossref","is-referenced-by-count":24,"title":["Travel to High-Volume Centers and Survival After Esophagectomy for Cancer"],"prefix":"10.1001","volume":"160","author":[{"given":"Sara","family":"Sakowitz","sequence":"first","affiliation":[{"name":"Cardiovascular Outcomes Research Laboratories (CORELAB), University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Shahyan","family":"Bakhtiyar","sequence":"additional","affiliation":[{"name":"Cardiovascular Outcomes Research Laboratories (CORELAB), University of California, Los 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