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Liver cirrhosis is one of the leading causes of death in the world and currently the only therapeutic option for end\u2010stage liver disease (e.g., acute liver failure, cirrhosis, chronic hepatitis, cholestatic diseases, metabolic diseases, and malignant neoplasms) is orthotropic liver transplantation. Transplantation of hepatocytes has been proposed and used as an alternative to whole organ transplant to stabilize and prolong the lives of patients in some clinical cases. Although these experimental therapies have demonstrated promising and beneficial results, their routine use remains a challenge due to the shortage of donor livers available for cell isolation, variable quality of those tissues, the potential need for lifelong immunosuppression in the transplant recipient, and high costs. Therefore, new therapeutic strategies and more reliable clinical treatments are urgently needed. Recent and continuous technological advances in the development of stem cells suggest they may be beneficial in this respect. In this review, we summarize the history of stem cell and induced pluripotent stem cell (iPSC) technology in the context of hepatic differentiation and discuss the potential applications the technology may offer for human liver disease modeling and treatment. This includes developing safer drugs and cell\u2010based therapies to improve the outcomes of patients with currently incurable health illnesses. We also review promising advances in other disease areas to highlight how the stem cell technology could be applied to liver diseases in the future. \u00a9 2016 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/0471140856.tx1413s67","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T14:27:04Z","timestamp":1454336824000},"source":"Crossref","is-referenced-by-count":23,"title":["The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases"],"prefix":"10.1002","volume":"67","author":[{"given":"Marc C.","family":"Hansel","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"},{"name":"McGowan Institute for Regenerative Medicine  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C.","family":"Davila","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Puerto Rico School of Medicine, Medical Sciences Campus  San Juan Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massoud","family":"Vosough","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Gramignoli","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen J.","family":"Skvorak","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Dorko","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics, Kansas University Medical Center  Kansas City Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Marongiu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Experimental Pathology, Unit of Experimental Medicine, University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Blake","sequence":"additional","affiliation":[{"name":"Genetically Modified Models Center of Emphasis, Pfizer  Groton Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Strom","sequence":"additional","affiliation":[{"name":"McGowan Institute for Regenerative Medicine  Pittsburgh Pennsylvania"},{"name":"Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1503"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007\u20101102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2973"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011756"},{"key":"e_1_2_10_6_1","unstructured":"Anonymous.2014.Yamanaka announces plan to establish global iPS cell bank. 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