{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T07:40:57Z","timestamp":1693294857253},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CP Toxicology"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many animal models have been devised for investigating the pathogenesis of intestinal lesions and for screening drugs for the treatment of intestinal ulcers in humans. Recently, particular attention has been focused on NSAID\u2010induced intestinal lesions as a result of the development of the capsule endoscope and double\u2010balloon endoscope. Ischemic enteritis, one of the most dramatic abdominal emergencies, is known to cause severe damage to the small intestine by a significant decrease of arterial blood flow in the small intestine. In this unit, two animal models for small intestinal damage induced by NSAIDs or intestinal ischemia are described. Also included are methods for lesion induction and evaluation of the damage as well as the measurement of pathogenic functional and biochemical changes. <jats:italic>Curr. Protoc. Toxicol<\/jats:italic>. 45:21.7.1\u201021.7.31. \u00a9 2010 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/0471140856.tx2107s45","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T19:46:37Z","timestamp":1283456797000},"source":"Crossref","is-referenced-by-count":3,"title":["Measurement of Small Intestinal Damage"],"prefix":"10.1002","volume":"45","author":[{"given":"Koji","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Kyoto Pharmaceutical University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Kyoto Pharmaceutical University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06223.x"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1993.tb00066.x"},{"key":"e_1_2_20_4_1","first-page":"G903","article-title":"Indomethacin\u2010induced leukocyte adhesion in mesenteric venules; role of lipoxygenase products","volume":"262","author":"Asako H.","year":"1992","journal-title":"Am. J. Physiol."},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.6.533"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90909-7"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(88)90161-8"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13940.x"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)90643-Y"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb14176.x"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(85)90060-5"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1601"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(94)90074-4"},{"key":"e_1_2_20_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"e_1_2_20_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-009-9027-4"},{"key":"e_1_2_20_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0199-9"},{"key":"e_1_2_20_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1978.tb00352.x"},{"key":"e_1_2_20_18_1","first-page":"25","article-title":"Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin\u2010induced small intestinal lesions in rats","volume":"50","author":"Konaka A.","year":"1999","journal-title":"J. Physiol. Pharmacol."},{"key":"e_1_2_20_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1999.0550"},{"key":"e_1_2_20_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.02.013"},{"key":"e_1_2_20_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(84)90202-6"},{"key":"e_1_2_20_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014725024519"},{"key":"e_1_2_20_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90633-9"},{"key":"e_1_2_20_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf901036r"},{"key":"e_1_2_20_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_20_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(77)90178-2"},{"key":"e_1_2_20_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(76)90189-1"},{"key":"e_1_2_20_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.156596"},{"key":"e_1_2_20_29_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.3.754"},{"key":"e_1_2_20_30_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.041715"},{"key":"e_1_2_20_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064419"},{"key":"e_1_2_20_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-8045-4"},{"key":"e_1_2_20_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90196-7"},{"key":"e_1_2_20_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15066.x"},{"key":"e_1_2_20_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00920471"}],"container-title":["Current Protocols in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/0471140856.tx2107s45","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/0471140856.tx2107s45","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/0471140856.tx2107s45","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:40:23Z","timestamp":1693204823000},"score":1,"resource":{"primary":{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/10.1002\/0471140856.tx2107s45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1002\/0471140856.tx2107s45"],"URL":"https:\/\/doi.org\/10.1002\/0471140856.tx2107s45","archive":["Portico"],"relation":{},"ISSN":["1934-9254","1934-9262"],"issn-type":[{"value":"1934-9254","type":"print"},{"value":"1934-9262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}