{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:18:46Z","timestamp":1761016726258},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CP Pharmacology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"Abstract<\/jats:title>Postural\u2010change\u2010induced (orthostatic) hypotension is defined as an excessive drop in arterial blood pressure occurring when moving toward an upright position. This side effect, which may limit the therapeutic use of some agents, can occur with drugs, such as adrenoceptor blockers and vasodilators, that dampen sympathetic reflex activity. Described in this unit is a procedure for evaluating the effects of test substances on the changes in blood pressure and heart rate that occur in an anesthetized, normotensive rat during a tilting challenge (head\u2010up position). In addition to being a relatively simple technique, this assay yields reproducible orthostatic hypotensive responses and allows for the investigation, in the same preparation, of several ascending doses of a test substance. Examples of results obtained with prazosin, an \u03b11\u2010adrenoceptor antagonist that is notorious for causing orthostatic hypotension, are provided for illustrative purposes. Curr. Protoc. Pharmacol<\/jats:italic>. 40:5.45.1\u20105.45.8. \u00a9 2008 by John Wiley & Sons, Inc.<\/jats:p>","DOI":"10.1002\/0471141755.ph0545s40","type":"journal-article","created":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T14:46:23Z","timestamp":1206110783000},"source":"Crossref","is-referenced-by-count":3,"title":["Orthostatic Hypotension Induced by Postural Change in the Rat (Tilt Test)"],"prefix":"10.1002","volume":"40","author":[{"given":"Philippe","family":"Guillaume","sequence":"first","affiliation":[{"name":"Porsolt and Partners Pharmacology Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Herv\u00e9","sequence":"additional","affiliation":[{"name":"Porsolt and Partners Pharmacology Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Picard","sequence":"additional","affiliation":[{"name":"Porsolt and Partners Pharmacology Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Porsolt and Partners Pharmacology Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.90.131"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199411010-00003"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03640.x"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0106s73"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(88)90021-4"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.81.63"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706039"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(81)90026-6"},{"key":"e_1_2_3_10_1","first-page":"595","article-title":"The antihypertensive effect of the angiotensin II receptor antagonist DuP 753 may not be due solely to angiotensin II receptor antagonism","volume":"262","author":"Ohlstein E.H.","year":"1992","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641968109033663"},{"key":"e_1_2_3_12_1","first-page":"801","article-title":"The direct negative chronotropic action of prazosin on the canine sinus node","volume":"221","author":"Schwartz K.M.","year":"1982","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"e_1_2_3_13_1","first-page":"179S","article-title":"Differences in reflex control of arterial blood pressure and renin release during head\u2010up tilting in the cat","volume":"4","author":"Stella A.","year":"1978","journal-title":"Clin. Sci. Mol. Med. Suppl"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.77.61"},{"key":"e_1_2_3_15_1","first-page":"2503","article-title":"Phase I clinical trial of YM617, a new \u03b11 adrenoceptor antagonist\u2014First report: A single oral dose of conventional formulation in healthy male subjects","volume":"12","author":"Tsunoo M.","year":"1990","journal-title":"Rinshoiyaku"}],"container-title":["Current Protocols in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F0471141755.ph0545s40","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/0471141755.ph0545s40","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/0471141755.ph0545s40","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/0471141755.ph0545s40","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T20:12:45Z","timestamp":1692475965000},"score":1,"resource":{"primary":{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/10.1002\/0471141755.ph0545s40"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/0471141755.ph0545s40"],"URL":"https:\/\/doi.org\/10.1002\/0471141755.ph0545s40","archive":["Portico"],"relation":{},"ISSN":["1934-8282","1934-8290"],"issn-type":[{"value":"1934-8282","type":"print"},{"value":"1934-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}