{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T05:40:11Z","timestamp":1738993211919,"version":"3.37.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CP Pharmacology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The protocols described in this unit are used to assess the effects of new chemical entities on hypertension in conscious rats. In the spontaneously hypertensive rat (SHR) model, the results obtained with the reference compounds clonidine, prazosin, propranolol, and captopril are provided for illustration. All compounds demonstrate antihypertensive activity, with captopril and prazosin being the least and the most active, respectively. In the deoxycorticosterone acetate (DOCA)\u2010salt model in the rat, the test substance shown as an example (a potential endothelin ET<jats:sub>A<\/jats:sub>\u2010receptor antagonist) prevents the development of hypertension in the first phase. However, the effects of treatment disappear in the very last phase of the study, suggesting the development of a malignant hypertension resistant to treatment in this model. In the Goldblatt hypertension rat model (renal artery stenosis), losartan prevents the development of hypertension. It does not modify the weight of the right and left kidneys but slightly reduces the degree of cardiac hypertrophy.<jats:italic>Curr. Protoc. Pharmacol<\/jats:italic>. 44:5.53.1\u20105.53.15. \u00a9 2009 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/0471141755.ph0553s44","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T13:29:52Z","timestamp":1236691792000},"source":"Crossref","is-referenced-by-count":2,"title":["Models of Cardiovascular Disease: Measurement of Antihypertensive Activity in the Conscious Rat (SHR, DOCA\u2010Salt, and Goldblatt Hypertension Models)"],"prefix":"10.1002","volume":"44","author":[{"given":"Philippe","family":"Guillaume","sequence":"first","affiliation":[{"name":"Porsolt and Partners Pharmacology Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Provost","sequence":"additional","affiliation":[{"name":"Porsolt and Partners Pharmacology Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Legrand","sequence":"additional","affiliation":[{"name":"Porsolt and Partners Pharmacology Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Godes","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Research\/Institute of Pharmacology Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Porsolt and Partners Pharmacology Boulogne\u2010Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(72)90190-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199708000-00014"},{"key":"e_1_2_6_4_1","first-page":"385","article-title":"Antihypertensive and hemodynamic properties of the potassium channel\u2010activating (\u2013) enantiomer of cromakalim in animal models","volume":"41","author":"Clapham J.C.","year":"1991","journal-title":"Arzneim.\u2010Forsch.\/Drug Res."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.1.1.31"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0022-3565(25)38879-8","article-title":"Effect of antihypertensive treatment on the left ventricular isomyosin profile in one\u2010clip, two kidney hypertensive rats","volume":"236","author":"Dussaule J.C.","year":"1986","journal-title":"J. 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