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The end\u2010point of the assay is locomotor hyperactivity, which is induced by PCP challenge following subchronic treatment with this NMDA receptor antagonist. The antipsychotics haloperidol, risperidone, and quetiapine all reduce hyperactivity in a dose\u2010dependent and selective manner. While the effects of other antipsychotics such as clozapine, olanzapine, and ziprasidone are similar to haloperidol, the interpretation of responses to them is often confounded by nonspecific effects during habituation.<jats:italic>Curr. Protoc. Pharmacol<\/jats:italic>. 45:5.54.1\u20105.54.13. \u00a9 2009 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/0471141755.ph0554s45","type":"journal-article","created":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T16:16:35Z","timestamp":1243872995000},"source":"Crossref","is-referenced-by-count":2,"title":["Models of Aspects of Schizophrenia: Behavioral Sensitization Induced by Subchronic Phencyclidine Administration"],"prefix":"10.1002","volume":"45","author":[{"given":"Mikhail","family":"Kalinichev","sequence":"first","affiliation":[{"name":"Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow Essex United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon T.","family":"Bate","sequence":"additional","affiliation":[{"name":"Statistical Sciences, GlaxoSmithKline, Harlow Essex United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Declan N.C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Centre of Excellence for External Drug Discovery, GlaxoSmithKline, Harlow Essex United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.01.019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15106.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/70.1.199"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00524-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043456034"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(81)90086-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199101)47:1<159::AID-JCLP2270470125>3.0.CO;2-O"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02877-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3854"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.10.036"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yco.0000214340.14131.bd"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.10.1301"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00004-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19980615)52:6<709::AID-JNR10>3.0.CO;2-U"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420036091"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-373861-5.00008-4"},{"key":"e_1_2_7_18_1","first-page":"518","article-title":"Early neonatal experience of Long\u2010Evans rats results in long\u2010lasting changes in reactivity to a novel environment and morphine\u2010induced sensitization and tolerance","volume":"27","author":"Kalinichev M.","year":"2002","journal-title":"Neuropsychopharmacology"},{"volume-title":"Animal models of schizophrenia based on the NMDA receptor hypofunction hypothesis. 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