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The models include monogenic models in the leptin pathway, polygenic diet\u2010dependent models, and, in particular for their historical perspective, surgical and chemical models of obesity. However, there are far too many models to consider all of them comprehensively, especially those caused by selective molecular genetic approaches modifying one or more genes in specific populations of cells. Further, the generation and use of inducible transgenic animals (induced knock\u2010out or knock\u2010in) is not covered, even though they often carry significant advantages compared to traditional transgenic animals, e.g., influences of the genetic modification during the development of the animals can be minimized. The number of these animal models is simply too large to be covered in this unit.\n                    <jats:italic>Curr. Protoc. Pharmacol<\/jats:italic>\n                    . 58:5.61.1\u20105.61.18. \u00a9 2012 by John Wiley &amp; Sons, Inc.\n                  <\/jats:p>","DOI":"10.1002\/0471141755.ph0561s58","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T18:48:07Z","timestamp":1346784487000},"source":"Crossref","is-referenced-by-count":233,"title":["Overview of Animal Models of Obesity"],"prefix":"10.1002","volume":"58","author":[{"given":"Thomas A.","family":"Lutz","sequence":"first","affiliation":[{"name":"University of Zurich, Institute of Veterinary Physiology, Zurich Center of Integrative Human Physiology  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience, College of Medicine, University of Cincinnati Obesity Research Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.2002.1835"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1860"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0341"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.5.1253"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(85)90006-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01388"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.02.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000251723"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00674.2009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36714"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.139.11.4483"},{"key":"e_1_2_10_13_1","first-page":"148","article-title":"The Zucker\u2010fatty rat: A review","volume":"36","author":"Bray G.A.","year":"1977","journal-title":"Fed. 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