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As the ASD diagnosis is based primarily on behavioral evaluations in humans in the domains of social interaction, communication, and restricted interests, the murine phenotypes analogous to human autistic behaviors are highlighted for the different models and behaviors. Although genetically engineered mouse models with good construct and face validity are valuable for identifying and defining underlying pathophysiological mechanisms and for developing potential therapeutic interventions for the human condition, the translational value of various rodent behavioral assays remains a subject of debate. Significant challenges associated with modeling ASDs in rodents because of the clinical and molecular heterogeneity that characterize this disorder are also considered. <jats:italic>Curr. Protoc. Pharmacol<\/jats:italic>. 66:5.66.1\u20105.66.26. \u00a9 2014 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/0471141755.ph0566s66","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T13:20:39Z","timestamp":1409664039000},"source":"Crossref","is-referenced-by-count":60,"title":["Overview of Mouse Models of Autism Spectrum Disorders"],"prefix":"10.1002","volume":"66","author":[{"given":"Alexandra L.","family":"Bey","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Duke University School of Medicine  Durham North Carolina"},{"name":"Division of Medical Genetics, Department of Pediatrics, Duke University School of Medicine  Durham North Carolina"},{"name":"Duke Institute for Brain Sciences, Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.015"},{"key":"e_1_2_8_5_1","first-page":"1","article-title":"Prevalence of autism spectrum disorder among children aged 8 years \u2013 autism and developmental disabilities monitoring network, 11 sites, United States, 2010","volume":"63","author":"Autism Developmental Disabilities Monitoring Network","year":"2014","journal-title":"Morbid. 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