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Such discovery efforts are, in general, facilitated by rapid and high\u2010throughput cell\u2010based assays of receptor\/ion channel\u2010mediated signaling processes to screen diverse chemical libraries of compounds possessing activator or inhibitor activities at the desired target. The availability of the Flurometric Image Plate Reader (FLIPR) has made rapid assays of cellular signaling processes feasible by simultaneous kinetics measurement of cell\u2010based fluorescence changes in a 96\u2010 or 384\u2010well format. 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