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Often these individuals have also been exposed to certain environmental factors that increase susceptibility, such as dietary components. Murine models of <jats:italic>Helicobacter<\/jats:italic>\u2010induced gastric cancer are valuable tools for investigating the mechanisms responsible for the stepwise pathological changes of chronic atrophic gastritis, intestinal metaplasia, dysplasia and gastric adenocarcinoma. <jats:italic>Helicobacter felis<\/jats:italic> colonization greatly accelerates the development of gastric neoplasia in mice, and causes pathologies similar to those observed with <jats:italic>Helicobacter pylori<\/jats:italic>\u2010associated gastric carcinogenesis in humans. These mouse models are therefore useful for investigating genetic and environmental factors that may be involved in the pathogenesis and treatment of gastric cancer. Detailed in these protocols are procedures for inducing <jats:italic>Helicobacter<\/jats:italic>\u2010associated carcinogenesis in mice as well as the histological analysis and interpretation of gastric pathology in these animals. \u00a9 2015 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/0471141755.ph1434s69","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T09:43:41Z","timestamp":1433238221000},"source":"Crossref","is-referenced-by-count":10,"title":["Murine Models of <i>Helicobacter<\/i> (<i>pylori or felis<\/i>)\u2010associated Gastric Cancer"],"prefix":"10.1002","volume":"69","author":[{"given":"Carrie A.","family":"Duckworth","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Gastroenterology Research Unit, Institute of Translational Medicine, University of Liverpool  Liverpool United Kingdom"},{"name":"Authors share first authorship"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Burkitt","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Gastroenterology Research Unit, Institute of Translational Medicine, University of Liverpool  Liverpool United Kingdom"},{"name":"Authors share first authorship"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Gastroenterology Research Unit, Institute of Translational Medicine, University of Liverpool  Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryony N.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Gastroenterology Research Unit, Institute of Translational Medicine, University of Liverpool  Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.F.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Gastroenterology Research Unit, Institute of Translational Medicine, University of Liverpool  Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Mark","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Gastroenterology Research Unit, Institute of Translational Medicine, University of Liverpool  Liverpool United Kingdom"},{"name":"Correspondence: Prof D. Mark Pritchard, Department of Cellular and Molecular Physiology, Gastroenterology Research Unit, Institute of Translational Medicine, University of Liverpool, Ashton St, Liverpool, L69 3GE. Tel: 0151 794 5772; e\u2010mail: <i>dmpritch@liv.ac.uk<\/i>"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_2_18_2_1","first-page":"S0959","article-title":"Recent trends in incidence of five common cancers in 26 European countries since 1988: Analysis of the European Cancer Observatory","author":"Arnold M.","year":"2013","journal-title":"Eur. J. 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