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Detailed materials and methods required for the purification of both PLP and MBP are also described. A protocol for isolating CNS\u2010infiltrating lymphocytes in EAE mice is included. Modifications of the specified protocols may be necessary for efficient induction of active or adoptive EAE in other mouse strains. <jats:italic>Curr. Protoc. Immunol<\/jats:italic>. 88:15.1.1\u201015.1.20. \u00a9 2010 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/0471142735.im1501s88","type":"journal-article","created":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T17:19:45Z","timestamp":1265649585000},"source":"Crossref","is-referenced-by-count":104,"title":["Experimental Autoimmune Encephalomyelitis in the Mouse"],"prefix":"10.1002","volume":"88","author":[{"given":"Stephen D.","family":"Miller","sequence":"first","affiliation":[{"name":"Northwestern University  Evanston Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Karpus","sequence":"additional","affiliation":[{"name":"Northwestern University  Evanston Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd Scott","family":"Davidson","sequence":"additional","affiliation":[{"name":"NIAID, NIH  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.153.10.4349"},{"key":"e_1_2_9_3_1","first-page":"316","article-title":"Genetics of experimental autoimmune encephalomyelitis in the mouse","volume":"52","author":"Andersson A.","year":"2004","journal-title":"Arch. 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