{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:06:35Z","timestamp":1792670795073,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CP in Immunology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many forms of glomerulonephritis are mediated by autoimmunity. While autoantibodies are often pathogenic, cell\u2010mediated immunity plays an important role in a number of forms of rapidly progressive glomerulonephritis. This unit describes the induction of cell\u2010mediated autoimmune glomerular disease in mice. One disease model, experimental anti\u2010glomerular basement membrane (GBM) disease, features autoreactivity to a well\u2010defined component of type IV collagen found in the GBM, \u03b13(IV)NC1. The other models the cell\u2010mediated effector response in forms of renal vasculitis, where autoantibodies to myeloperoxidase result in systemic neutrophil activation, resulting in their localization to the glomerulus and the subsequent deposition of myeloperoxidase within glomerular capillaries. There, myeloperoxidase acts as a \u201cplanted\u201d autoantigen and is recognized by effector autoreactive myeloperoxidase\u2010specific T cells. These models are useful both in defining mechanisms germane to the development of autoimmunity to \u03b13(IV)NC1 and myeloperoxidase, and in dissecting the role of cell\u2010mediated responses in effecting glomerular injury. \u00a9 2014 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/0471142735.im1527s107","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T13:54:55Z","timestamp":1415022895000},"source":"Crossref","is-referenced-by-count":12,"title":["T Cell Mediated Autoimmune Glomerular Disease in Mice"],"prefix":"10.1002","volume":"107","author":[{"given":"Joshua D.","family":"Ooi","sequence":"first","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poh\u2010Yi","family":"Gan","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Odobasic","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Holdsworth","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine  Clayton Australia"},{"name":"Department of Nephrology, Monash Health  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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