{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:51:25Z","timestamp":1761155485970},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CP in Immunology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This unit describes the utility of various mouse models of infection for studying pathogenesis and adaptive immune responses to the facultative intracellular bacteria pathogen <jats:named-content content-type=\"genus-species\"><jats:italic>Francisella tularensis<\/jats:italic><\/jats:named-content>. By judicious use of different combinations of mouse and bacterial strains, as well as different routes of infection, murine tularemia models may be used to explore a complete picture of <jats:named-content content-type=\"genus-species\"><jats:italic>F. tularensis<\/jats:italic><\/jats:named-content> infection and immunity. Moreover, studies using <jats:italic>Francisella<\/jats:italic>, particularly the Live Vaccine Strain (LVS), serve as a convenient and tractable model system that appears to be representative of mammalian host responses to intracellular pathogens in general. <jats:italic>Curr. Protoc. Immunol<\/jats:italic>. 93:19.14.1\u201019.14.16. \u00a9 2011 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/0471142735.im1914s93","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T20:19:20Z","timestamp":1301689160000},"source":"Crossref","is-referenced-by-count":31,"title":["Infection of Mice with <i>Francisella<\/i> as an Immunological Model"],"prefix":"10.1002","volume":"93","author":[{"given":"J. Wayne","family":"Conlan","sequence":"first","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences  Ottawa, Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangxue","family":"Chen","sequence":"additional","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences  Ottawa, Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharine M.","family":"Bosio","sequence":"additional","affiliation":[{"name":"Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases  NIH, Hamilton Montana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siobh\u00e1n C.","family":"Cowley","sequence":"additional","affiliation":[{"name":"Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, OVRR\/CBER\/U.S. FDA  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Elkins","sequence":"additional","affiliation":[{"name":"Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, OVRR\/CBER\/U.S. FDA  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4]]},"reference":[{"key":"e_1_2_14_2_1_1","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1128\/iai.56.8.2089-2093.1988","article-title":"Influence of genetic background on host resistance to experimental murine tularemia","volume":"56","author":"Anthony L.S.D.","year":"1988","journal-title":"Infect. Immun."},{"key":"e_1_2_14_2_2_1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1128\/jcm.22.2.212-215.1985","article-title":"Anti\u2010microbial susceptibility testing of Francisella tularensis with a modified Mueller\u2010Hinton broth","volume":"22","author":"Baker C.N.","year":"1985","journal-title":"J. Clin. Micro."},{"key":"e_1_2_14_2_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01322-08"},{"key":"e_1_2_14_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.07.034"},{"key":"e_1_2_14_2_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.21.2763"},{"key":"e_1_2_14_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)00084-9"},{"key":"e_1_2_14_2_7_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1409.014"},{"key":"e_1_2_14_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.09.012"},{"key":"e_1_2_14_2_9_1","first-page":"11","article-title":"Oral tularemia vaccine in man","volume":"6","author":"Hornick R.B.","year":"1966","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_14_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.09.077"},{"key":"e_1_2_14_2_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01834-06"},{"key":"e_1_2_14_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.02.014"},{"key":"e_1_2_14_2_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.87.3.676-683.1964"},{"key":"e_1_2_14_2_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00405-08"},{"key":"e_1_2_14_2_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.8.3129-3137.1994"},{"key":"e_1_2_14_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.12.003"},{"key":"e_1_2_14_2_17_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1409.009"},{"key":"e_1_2_14_2_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2644-2654.2005"},{"key":"e_1_2_14_3_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.1.194-203.2001"},{"key":"e_1_2_14_3_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030687"},{"key":"e_1_2_14_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0882-4010(03)00046-9"},{"key":"e_1_2_14_3_7_1","unstructured":"Elkins et al. 2003. Seeabove."},{"key":"e_1_2_14_3_9_1","unstructured":"KuoLeeet al. 2007a b. Seeabove."},{"key":"e_1_2_14_3_11_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1409.003"}],"container-title":["Current Protocols in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/0471142735.im1914s93","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:01:51Z","timestamp":1693224111000},"score":1,"resource":{"primary":{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/10.1002\/0471142735.im1914s93"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1002\/0471142735.im1914s93"],"URL":"https:\/\/doi.org\/10.1002\/0471142735.im1914s93","archive":["Portico"],"relation":{},"ISSN":["1934-3671","1934-368X"],"issn-type":[{"value":"1934-3671","type":"print"},{"value":"1934-368X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}