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These rearrangements can be detected as described in this unit by Southern blot hybridization or, in many instances, the polymerase chain reaction (PCR). Specific chromosomal translocations can also serve as markers for clonality, for malignant transformation, and for various defined subtypes of hematopoietic cancers. PCR protocols are described for detection of the two most commonly assayed translocations, t(9;22) of chronic myelogenous leukemia or acute lymphoblastic leukemia, and t(14;18) of follicular lymphomas.<\/jats:p>","DOI":"10.1002\/0471142905.hg1004s02","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T14:00:54Z","timestamp":1086789654000},"source":"Crossref","is-referenced-by-count":0,"title":["Molecular Analysis of DNA Rearrangements in Leukemias and Non\u2010Hodgkin's Lymphomas"],"prefix":"10.1002","volume":"2","author":[{"given":"Janina","family":"Longtine","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Fox","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Sklar","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,5,15]]},"reference":[{"key":"e_1_2_11_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198508293130901"},{"key":"e_1_2_11_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1986.tb01470.x"},{"key":"e_1_2_11_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.21.8536"},{"key":"e_1_2_11_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb02643.x"},{"key":"e_1_2_11_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_11_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.2.593"},{"key":"e_1_2_11_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8608"},{"key":"e_1_2_11_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198704303161803"},{"key":"e_1_2_11_1_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.12.3275.3275"},{"key":"e_1_2_11_1_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.4.874.874"},{"key":"e_1_2_11_1_12_1","first-page":"13","article-title":"Clonal composition of T cells in lymphomatoid papulosis","volume":"126","author":"Kadin M.E.","year":"1987","journal-title":"Am. 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