{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T19:28:46Z","timestamp":1694114926862},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,2,15]],"date-time":"2002-02-15T00:00:00Z","timestamp":1013731200000},"content-version":"vor","delay-in-days":137,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CP Human Genetics"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This unit provides a set of protocols for introducing recombinant genes into normal, injured, and atherosclerotic arteries. The protocols include animal preparation, surgical techniques, and delivery systems. Protocols describe gene delivery to normal, injured, and stented porcine iliofemoral arteries, employing a double balloon infusion catheter to deliver the vector. Another basic protocol describes gene delivery to atherosclerotic arteries using a hyperlipidemic double\u2010injury rabbit model, and requires surgical exposure of the artery and instillation of the gene vector via a catheter. Additional protocols describe gene delivery to normal and injured murine carotid and femoral arteries. An <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#cphg1301-prot-0006\" \/> describes a percutaneous method for arterial gene delivery. These protocols may be adapted to deliver genes to either injured or noninjured atherosclerotic arteries.<\/jats:p>","DOI":"10.1002\/0471142905.hg1301s31","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T14:00:54Z","timestamp":1086789654000},"source":"Crossref","is-referenced-by-count":0,"title":["Gene Transfer to Arteries"],"prefix":"10.1002","volume":"31","author":[{"given":"Levent M.","family":"Aky\u00fcrek","sequence":"first","affiliation":[{"name":"National Heart, Lung, and Blood Institute, NIH  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"San","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, NIH  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth G.","family":"Nabel","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, NIH  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ripudamanjit","family":"Singh","sequence":"additional","affiliation":[{"name":"Mayo Clinic and Foundation  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Simari","sequence":"additional","affiliation":[{"name":"Mayo Clinic and Foundation  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,2,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401832"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2001.0315"},{"key":"e_1_2_10_4_1","first-page":"51","article-title":"Efficient catheter\u2010mediated gene transfer into the heart using replication\u2010defective adenovirus","volume":"1","author":"Barr E.","year":"1994","journal-title":"Gene 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