{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:43:08Z","timestamp":1778856188242,"version":"3.51.4"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":1420,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007546","name":"French National Research Program for Environmental and Occupational Health of Anses","doi-asserted-by":"publisher","award":["EST-2014\/1\/077"],"award-info":[{"award-number":["EST-2014\/1\/077"]}],"id":[{"id":"10.13039\/501100007546","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Musculoskeletal disorders, mainly carpal tunnel syndrome, represent a leading cause of compensation claims of workers worldwide. Despite this, and the fact that occupational exposures to biomechanical factors and neurotoxic chemicals have been individually associated with peripheral nerve damage, the prevalence of occupational co-exposure to biomechanical factors and neurotoxic chemicals has rarely been explored. Therefore, our aim was to assess the prevalence of occupational co-exposure to biomechanical factors and neurotoxic chemicals in a national representative sample of the French working population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study was based on the French representative cross-sectional survey SUMER 2010. A total of 47 983 employees who had worked in their current job for at least one year were included. Occupational exposure to biomechanical factors and neurotoxic chemicals within the previous week of work were assessed using a questionnaire during face-to-face interviews with occupational physicians.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Approximately 5% of male employees and 1% of female employees were co-exposed to biomechanical factors and neurotoxic chemicals. This prevalence was up to 10% among male blue-collar workers and 13%, 8%, and 6%, respectively, among male employees in the construction, agriculture, and industry sectors. Male employees under 30 years old, in apprenticeships, and working in small companies were more co-exposed to biomechanical factors and neurotoxic chemicals than their counterparts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Occupational co-exposure to biomechanical factors and neurotoxic chemicals was observed in a significant proportion of French male employees, suggesting that further studies are required to investigate its potential adverse effects on peripheral neuropathies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/1348-9585.12090","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T16:40:36Z","timestamp":1574268036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Occupational co-exposure to biomechanical factors and neurotoxic chemicals in a representative sample of French employees"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9683-6256","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Bertin","sequence":"first","affiliation":[{"name":"Univ Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail)\u2014UMR_S 1085 , Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8514-1416","authenticated-orcid":false,"given":"Thi-Hai-Yen","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Univ Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail)\u2014UMR_S 1085 , Angers, France"},{"name":"Faculty of Pharmacy, Ho Chi Minh City University of Medicine and Pharmacy , Ho Chi Minh City, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Bonvallot","sequence":"additional","affiliation":[{"name":"Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail)\u2014UMR_S 1085 , Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Bodin","sequence":"additional","affiliation":[{"name":"Univ Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail)\u2014UMR_S 1085 , Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Roquelaure","sequence":"additional","affiliation":[{"name":"Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail)\u2014UMR_S 1085 , Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"2024071807555277300_joh212090-bib-0001","volume-title":"Rapport de Gestion 2017\u2014Assurance Maladie\u2014Risques Professionnels. Paris","author":"Cnamts","year":"2019"},{"issue":"1","key":"2024071807555277300_joh212090-bib-0002","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12891-015-0685-0","article-title":"Association between work-related biomechanical risk factors and the occurrence of carpal tunnel syndrome: an overview of systematic reviews and a meta-analysis of current research","volume":"16","author":"Kozak","year":"2015","journal-title":"BMC Musculoskelet Disord"},{"key":"2024071807555277300_joh212090-bib-0003","volume-title":"Experimental and Clinical Neurotoxicology","author":"Spencer","year":"2000","edition":"2nd"},{"issue":"2","key":"2024071807555277300_joh212090-bib-0004","first-page":"78","article-title":"Psychomotor effects of mixed organic solvents on rubber workers","volume":"5","author":"Aminian","year":"2014","journal-title":"Int J Occup Environ Med"},{"issue":"10","key":"2024071807555277300_joh212090-bib-0005","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1136\/oem.52.10.648","article-title":"Neurotoxicity among pesticide applicators exposed to organophosphates","volume":"52","author":"Stokes","year":"1995","journal-title":"Occup Environ Med"},{"issue":"4","key":"2024071807555277300_joh212090-bib-0006","first-page":"396","article-title":"Etude de la co-exposition aux contraintes physiques et aux produits chimiques neurotoxiques chez les salaries des Pays de la Loire","volume":"75","author":"Petit","year":"2014","journal-title":"Arch des Mal Prof l\u2019Environnement"},{"issue":"17","key":"2024071807555277300_joh212090-bib-0007","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4239\/wjd.v7.i17.342","article-title":"Entrapment neuropathies in diabetes mellitus","volume":"7","author":"Rota","year":"2016","journal-title":"World J Diabetes"},{"issue":"4","key":"2024071807555277300_joh212090-bib-0008","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.neuro.2012.03.010","article-title":"Chronic solvent-induced encephalopathy: European consensus of neuropsychological characteristics, assessment, and guidelines for diagnostics","volume":"33","author":"Van Valen","year":"2012","journal-title":"Neurotoxicology"},{"key":"2024071807555277300_joh212090-bib-0009","doi-asserted-by":"crossref","DOI":"10.1201\/b11547","volume-title":"Biomechanics of the Upper Limbs","author":"Freivalds","year":"2011"},{"issue":"1","key":"2024071807555277300_joh212090-bib-0010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pjnns.2017.09.009","article-title":"Bilateral carpal tunnel syndrome\u2014a review","volume":"52","author":"Dec","year":"2018","journal-title":"Neurol Neurochir Pol"},{"issue":"1","key":"2024071807555277300_joh212090-bib-0011","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/ije\/dyr236","article-title":"The exposome: from concept to utility","volume":"41","author":"Wild","year":"2012","journal-title":"Int J Epidemiol"},{"key":"2024071807555277300_joh212090-bib-0012","volume-title":"L\u2019exposition des salari\u00e9s aux facteurs de p\u00e9nibilit\u00e9 dans le travail. Dares Anal","author":"Rivalin","year":"2014"},{"key":"2024071807555277300_joh212090-bib-0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5271\/sjweh.637","article-title":"Criteria document for evaluating the work-relatedness of upper-extremity musculoskeletal disorders","volume":"27","author":"Sluiter","year":"2001","journal-title":"Scand J Work Environ Health"},{"issue":"9553","key":"2024071807555277300_joh212090-bib-0014","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","article-title":"Developmental neurotoxicity of industrial chemicals","volume":"368","author":"Grandjean","year":"2006","journal-title":"Lancet"},{"issue":"11","key":"2024071807555277300_joh212090-bib-0015","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s10661-016-5662-z","article-title":"Neurotoxicity effect of formaldehyde on occupational exposure and influence of individual susceptibility to some metabolism parameters","volume":"188","author":"Zendehdel","year":"2016","journal-title":"Environ Monit Assess"},{"issue":"2","key":"2024071807555277300_joh212090-bib-0016","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1742-7843.2006.pto_254.x","article-title":"Neurological effects of white spirit: contribution of animal studies during a 30-year period","volume":"98","author":"Nielsen","year":"2006","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2024071807555277300_joh212090-bib-0017","volume-title":"Exposure to Multiple Hazards among Australian Workers","author":"Australia Safe Work","year":"2015"},{"key":"2024071807555277300_joh212090-bib-0018","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neuro.2014.08.004","article-title":"An uncommon pattern of polyneuropathy induced by lifetime exposures to drift containing organophosphate pesticides","volume":"45","author":"Ophir","year":"2014","journal-title":"Neurotoxicology"}],"container-title":["Journal of Occupational Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1348-9585.12090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1348-9585.12090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/joh\/article-pdf\/62\/1\/e12090\/58561926\/joh212090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joh\/article-pdf\/62\/1\/e12090\/58561926\/joh212090.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T07:56:08Z","timestamp":1721289368000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joh\/article\/doi\/10.1002\/1348-9585.12090\/7249952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,20]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,17]]}},"URL":"https:\/\/doi.org\/10.1002\/1348-9585.12090","relation":{},"ISSN":["1341-9145","1348-9585"],"issn-type":[{"value":"1341-9145","type":"print"},{"value":"1348-9585","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2019,11,20]]},"assertion":[{"value":"2019-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12090"}}