{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:05:37Z","timestamp":1788818737127,"version":"build-2803163510"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":1378,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":263,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"publisher","award":["16K09107"],"award-info":[{"award-number":["16K09107"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"publisher","award":["19H03906"],"award-info":[{"award-number":["19H03906"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A male worker with indium-tin oxide (ITO)-induced pneumoconiosis underwent bilateral lung transplantation (LT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Post-LT histopathological investigations of the isolated lungs and hilar lymph nodes were performed and indium concentration in serum (In-S) and serum Krebs von den Lungen-6 (KL-6) were tracked for 122 weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>He has attained the ultimate treatment goal of &amp;gt; 2-year survival. The main histopathological characteristics were pan-lobular emphysematous change, interstitial fibrosis, and lymphocytic infiltration in the peribronchiolar\/perivascular portions, and numerous cholesterol clefts and giant cells containing brown particles. These findings support the conclusion that the lung injury was caused by the inhalation of ITO. Metal element mapping and indium in the isolated lungs revealed that inhaled ITO particles in humans migrate to the lymph nodes. In-S remained at remarkably high levels (\u226530 ng\/mL) and showed wide fluctuation with bimodality until 46 weeks after LT, but KL-6 remained in the normal range for almost the entire period. The indium concentration in the donor\u2019s resection lung at 10 weeks after LT was 143.5 ng\/g wet-weight, which was only one one-thousandth of the recipient\u2019s lung (161 \u00b5g\/g wet-weight). After 48 weeks of LT, the recipient\u2019s In-S had gradually decreased; the biological half-life was 1.2 years. These results clearly suggest that indium remaining in the recipient\u2019s tissues did not adversely influence the transplant donor\u2019s lungs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The transplanted donor\u2019s lungs were not influenced by indium in the recipient\u2019s organs. Bilateral LT is thus an effective treatment option in severe indium lung disease cases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/1348-9585.12165","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T07:15:59Z","timestamp":1600586159000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Indium kinetics in an indium exposed worker before and after bilateral lung transplantation"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-1315","authenticated-orcid":false,"given":"Makiko","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Keio University School of Medicine , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Hirata","sequence":"additional","affiliation":[{"name":"Environmental Medicine, Graduate School of Medical Sciences, Kyushu University , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2481-3888","authenticated-orcid":false,"given":"Makoto","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fukuoka University Hospital , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyo","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Environmental Medicine, Graduate School of Medical Sciences, Kyushu University , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asahi","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of General Thoracic, Breast and Pediatric Surgery, Fukuoka University Hospital , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kumazoe","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Hospital Organization Omuta National Hospital , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Wakamatsu","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, National Hospital Organization Omuta National Hospital , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of General Thoracic, Breast and Pediatric Surgery, Fukuoka University Hospital , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Omae","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Keio University School of Medicine , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"issue":"3","key":"2024071808011719300_joh212165-bib-0001","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1539\/joh.45.137","article-title":"Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide","volume":"45","author":"Homma","year":"2003","journal-title":"J Occup Health"},{"issue":"1","key":"2024071808011719300_joh212165-bib-0002","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/oem.2006.029124","article-title":"Exposure to hardly soluble indium compounds in the ITO producing and recycling plants is a new potent risk of interstitial lung damage","volume":"65","author":"Hamaguchi","year":"2008","journal-title":"Occup Environ Med"},{"issue":"6","key":"2024071808011719300_joh212165-bib-0003","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1539\/joh.L9077","article-title":"Causal relationship between indium compound inhalation and effects on the lungs","volume":"51","author":"Nakano","year":"2009","journal-title":"J Occup Health"},{"issue":"5","key":"2024071808011719300_joh212165-bib-0004","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1378\/chest.13-2484","article-title":"Five-year cohort study: emphysematous progression of indium-exposed workers","volume":"146","author":"Nakano","year":"2014","journal-title":"Chest"},{"issue":"11","key":"2024071808011719300_joh212165-bib-0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/thoraxjnl-2014-206380","article-title":"High levels of indium exposure relate to progressive emphysematous changes: a 9-year longitudinal surveillance of indium workers","volume":"70","author":"Amata","year":"2015","journal-title":"Thorax"},{"key":"2024071808011719300_joh212165-bib-0006","first-page":"7","article-title":"Toxicology and carcinogenesis studies of Indium (CAS No. 22398\u201390-7) Phosphide in F344\/N rats and B6C3F1 mice (Inhalation Studies)","volume-title":"Natl Toxicol Program Tech Rep Ser","author":"National Toxicology Program","year":"2001"},{"issue":"3","key":"2024071808011719300_joh212165-bib-0007","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1539\/joh.10-0057-OA","article-title":"Inhalation carcinogenicity and chronic toxicity of indium-tin oxide in rats and mice","volume":"53","author":"Nagano","year":"2011","journal-title":"J Occup Health"},{"issue":"3","key":"2024071808011719300_joh212165-bib-0008","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/1348-9585.12050","article-title":"Possibility of lung cancer risk in indium-exposed workers: An 11-year multicenter cohort study","volume":"61","author":"Nakano","year":"2019","journal-title":"J Occup Health"},{"issue":"5","key":"2024071808011719300_joh212165-bib-0009","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1539\/joh.16-0076-CS","article-title":"An advanced case of indium lung disease with progressive emphysema","volume":"58","author":"Nakano","year":"2016","journal-title":"J Occup Health"},{"issue":"6","key":"2024071808011719300_joh212165-bib-0010","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1378\/chest.11-1880","article-title":"Indium lung disease","volume":"141","author":"Cummings","year":"2012","journal-title":"Chest"},{"issue":"5641","key":"2024071808011719300_joh212165-bib-0011","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/bmj.1.5641.396","article-title":"Cholesterol granuloma of the lung","volume":"1","author":"Anonymous","year":"1969","journal-title":"Br Med J"},{"issue":"1","key":"2024071808011719300_joh212165-bib-0012","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1183\/09031936.04.10012704","article-title":"Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide","volume":"25","author":"Homma","year":"2005","journal-title":"Er Respir J"},{"issue":"9","key":"2024071808011719300_joh212165-bib-0013","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0002-9343(65)90206-8","article-title":"Desquamative interstitial pneumonia","volume":"39","author":"Liebow","year":"1965","journal-title":"Am J Med"},{"issue":"4","key":"2024071808011719300_joh212165-bib-0014","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1183\/09031936.05.00021005","article-title":"Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity","volume":"26","author":"Cottin","year":"2005","journal-title":"Eur Respir J"},{"issue":"2","key":"2024071808011719300_joh212165-bib-0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1539\/joh.14-0123-BR","article-title":"Tissue distribution of indium after repeated intratracheal instillations of indium-tin oxide into the lungs of hamsters","volume":"57","author":"Tanaka","year":"2015","journal-title":"J Occup Health"}],"container-title":["Journal of Occupational Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1348-9585.12165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1348-9585.12165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/joh\/article-pdf\/62\/1\/e12165\/58561909\/joh212165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joh\/article-pdf\/62\/1\/e12165\/58561909\/joh212165.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T08:01:35Z","timestamp":1721289695000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joh\/article\/doi\/10.1002\/1348-9585.12165\/7249997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,17]]}},"URL":"https:\/\/doi.org\/10.1002\/1348-9585.12165","relation":{},"ISSN":["1341-9145","1348-9585"],"issn-type":[{"value":"1341-9145","type":"print"},{"value":"1348-9585","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12165"}}